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Ulcer occurs when stomach acid damages the lining of the digestive tract caused by the bacteria Helicobacter pylori. Many pharmacological activities such as antiulcer activity can act against ulcer. Medicinal plants like Mimosa pudica and Vachellia nilotica has the antiulcer activity in a wide range. To study the antiulcer activity in medicinal plants using insilco studies by comparing the phytocompounds of plants with histamine 2 receptor as a binding protein, which is present in the stomach lining of homosapiens. Histamine 2 receptor was modelled using Swiss model and the ligand structures are obtained from PUB-CHEM, viewed easily via PYMOL. All the phytocompounds showed good binding energy with modelled protein on the docking methodology. Specifically ascorbic acid exhibited the lower binding energy of value -3.24 kcal/mol, indole and catechin shows highest binding energy of value -4.99 kcal/mol and -4.98 kacl/mol respectively. The results can be useful for the design and development of phytocompounds having better inhibitory activity against several types of ulcer.
Dle HH, Laidlaw PP. Histamine shock. J. Physiol. 1919;52:355–390.
Federico M, Natalia F. Current knowledge and perspectives on histamine H1 and H2 receptor pharmacology: Functional selectivity, receptor crosstalk, and repositioning of classic histaminergic ligands. Mol Pharmacol. 2016;90:640–648.
Kühn B, Schmid A, Harteneck C, Gudermann T, Schultz G. G proteins of the Gq family couple the H2 histamine receptor to phospholipase C. Mol Endocrinol. 1996;12:1697-707.
Parsons ME, Ganellin CR. Histamine and its receptors. Br. J. Pharmacol. 2006;14:S127–S135.
Daly MJ, Humphray JM, Stables R. Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br J Pharmacol. 1981;72:49-54.
Smit MJ, Leurs R, Alewijnse AE, Blauw J, Van Nieuw Amerongen GP, Van De Vrede Y “et.al.”. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proc Natl Acad Sci. 1996;93:6802–6807.
Hershcovici T, Fass R. Pharmacological management of GERD: where does it stand now? Trends. Pharmacol. Sci. 2011;32:258–264.
Burde R. Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H2-receptors. Naunyn Schmiedebergs Arch. Pharmacol. 1989;340:671–678.
Debjit B, Chiranjib C, Tripathi KK, Pankaj KP, Sampath Kumar. Recent trends of treatment and medication peptic ulcerative disorder. International Journal of PharmTech Research. 2010;2(1):970–980.
Vyawahare NS, Deshmukh VV, Godkari MR, Kagathara VG. Plants with anti-ulcer activity. Pharmacognosy Review. 2009;3:108–115.
Brooks FP. The pathophysiology of peptic ulcer disease. Digestive Diseases and Sciences. 1985;30(supplement 11):15S–29S.
Ghani A. Medicinal plants of Bangladesh with chemical constitutes and uses. 2nd ed .Dhaka: Asiatic Society of Bangladesh; 1998.
Gaurikarwani. Hepato protective activity of Mimosa pudica Linn in carbon tetra chloride induced Hepato protective in rats. J of Herbal Medicine and Toxicology. 2011 Dec 25;5(1):27-15.
Sharma AK, Kumar A, et al. Studies on antimicrobial and immunomodulatory effects of hot aqueous extract of Acacia nilotica L. Leaves against Common Veterinary Pathogens. Veterinary Medicine International; 2014.
Ghani N. Khazainul Advia. New Delhi: Idarae Kitabul Shifa; YNM: 339-340
Rajvaidhya S, Nagori BP, et al. A review on Acacia arabica - An Indian medicinal plant. IJPSR 2012;3(7):1995-2005.
Ali A, Akhtar N, et al. Acacia nilotica: A plant of multipurpose medicinal uses. Journal of Medicinal Plants Research. 2012;6(9):1492-1496.
Meena PD, Kaushik P, et al. Anticancer and Antimutagenic Properties of Acacia nilotica (Linn.) on 7,12- Dimethylbenz (a) anthracene-induced Skin Papillomagenesis in Swiss Albino Mice. Asian Pacific Journal of Cancer Prevention. 2006;7:627-632.
Bargali K, Bargali SS. Acacia nilotica: a multipurpose leguminous plant. Nature and Science. 2009;7(4): 11-19 Available:https://www.uniprot.org/uniprot/P25021.
NCBI Resource Coordinators. Database resources of the National Center for Biotechnology Information.Nucleic Acids Res. 2018;46(D1):D8-D13.
Kim S, Thiessen PA, Bolton EE, et al. PubChem Substance and Compound databases. Nucleic Acids Res. 2016;44(D1):D1202–D13. The most recent overview of the PubChem Substand and Compound databases. [PMC free article]. [PubMed]. [Google Scholar].
Wang YL, Suzek T, Zhang J, et al. PubChem BioAssay: 2014 update. Nucleic Acids Res. 2014;42(D1):D1075–D82. The most recent overview of the PubChem BioAssay database. [PMC free article]. [PubMed]. [Google Scholar].
PubChem. National Center for Biotechnology Information; Bethesda, MD; 2004. Available at: https://pubchem.ncbi.nlm.nih.gov [Last accessed 19 July 2016]. [Google Scholar].
Willemijntje AH, Pankaj JP. Agents used for control of gastric acidity and treatment of peptic ulcers and gastroesophageal reflux disease. Pharmacol Basis Ther GH Joel EL Lee. 2001;1010-1011.
Awaad AS, El-Meligy RM, Soliman GA. Natural products in treatment of ulcerative colitis and peptic ulcer. J Saudi Chem Soc. 2013;101-124.