PROGRESSIVE CHANGES IN GAIT, KINEMATIC, HORIZONTAL AND VERTICAL ACTIVITIES IN RESPONSE TO OLEIC ACID AND HEAVY METAL EXPOSURE

Main Article Content

O. N. ILOCHI
A. N. CHUEMERE

Abstract

Oleic acid has a natural occurrence in most plants and is isolated for use in various industrial and medicinal purposes. The progressive changes in gait, kinematic, vertical and horizontal activities were studied in heavy metal exposure. Male wistar rats were randomly sampled in four groups of control as group i and oleic acid 1, 1.5 and 2ml co-treated with AlCl3 at 50mg/kg as groups’ ii, iii and iv, respectively. Oleic acid, especially at 1.5 and 2ml co-treatment with AlCl3, significantly (P<0.05) enhanced gait, kinematic, vertical and horizontal activities compared to control. same co-treatment doses caused no significant change in calcium compared to control, but plasma level of muscle function markers changed significantly which may reveal a possible link between the dose of oleic acid treatment in heavy metal exposure and skeletal muscle activity. Oleic acid, at the studied dose may prevent or ameliorate the adverse neurologic changes caused by aluminum chloride.

Keywords:
Oleic acid, heavy metal, AlCl3, gait, kinematic

Article Details

How to Cite
ILOCHI, O. N., & CHUEMERE, A. N. (2021). PROGRESSIVE CHANGES IN GAIT, KINEMATIC, HORIZONTAL AND VERTICAL ACTIVITIES IN RESPONSE TO OLEIC ACID AND HEAVY METAL EXPOSURE. Asian Journal of Advances in Medical Science, 3(4), 232-241. Retrieved from http://mbimph.com/index.php/AJOAIMS/article/view/2579
Section
Original Research Article

References

Amtul Z, Westaway D, Cechetto DF, Rozmahel RF. “Oleic acid ameliorates amyloidosis in cellular and mouse models of Alzheimer’s disease”. Brain Pathology. 2011; 21:321–329.

Blondeau N. Alpha-linolenic acid: an omega-3 fatty acid with neuroprotective properties-ready for use in the stroke clinic? Biomedical Research Institute. 2015;519830. 5

Debbabi M. Protective Effects of α-tocopherol, γ-tocopherol and oleic acid, three compounds of olive oils, and no effect of trolox, on 7-ketocholesterol-induced mitochondrial and peroxisomal dysfunction in microglial BV-2 cells. Int. J. Mol. Science. 2016;17-1973.

Lewis MD, Bailes J. Neuroprotection for the warrior: dietary supplementation with omega-3 fatty acids. Mil. Med. 2011;176: 1120–1127.

Rioux FM, Innis SM. Oleic acid (18:1) in plasma, liver and brain myelin lipid of piglets fed from birth with formulas differing in 18:1 content. J. Nutr. 1992;122:1521–1528.

Velasco A, Tabernero A, Medina JM. Role of oleic acid as a neurotrophic factor is supported in vivo by the expression of GAP-43 subsequent to the activation of SREBP-1 and the up-regulation of stearoyl-CoA desaturase during postnatal development of the brain. Brain Research. 2003;977:103–111.

Arous C, Naimi M, Van Obberghen E. Oleate-mediated activation of phospholipase D and mammalian target of rapamycin (mTOR) regulates proliferation and rapamycin sensitivity of hepatocarcinoma cells. Diabetologia. 2011;54: 954–964.

Akinola OB, Biliaminu SA, Adediran RA. Characterization of prefrontal cortex microstructure and antioxidant status in a rat model of neurodegeneration induced by aluminium chloride and multiple lowdose streptozotocin. Metab Brain Dis. 2015;30: 1531–1536.

Bhattacharjee S, Zhao Y, Hill JM. Aluminum and its potential contribution to Alzheimer’s disease (AD). Front. Aging Neurosci. 2014;6: 32-37.

Chakrabarty M, Bhat P, Kumari S. Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastruspaniculatus seed oil: Neurobehavioural, biochemical, histological study. J Pharmacol Pharmacother. 2012;5:35-39.

Kumar V and Gill KD. Oxidative stress and mitochondrial dys¬function in aluminium neurotoxicity and its amelioration: a review. Neurotoxicology. 2014;41:154‐ 66.

Ilochi Ogadinma, Arthur Nwafor Chuemere, Ekwem Ikechukwu, Bassey Samuel. Neuroprotective and Antitoxic Potential of Hydromethanolic Extract of Allium cepa in Experimental Rats. European Journal of Pharmaceutical and Medical Research. EJPMR. 2018;5(9):138-143.

ISSN 2394-3211 EJPMR.

Paul C. Akangbou, Arthur N. Chuemere, Ogadinma Ilochi. Impairment of cardiovascular function indices in male rats induced by aluminium-tainted water: Atherogenic indices and predictor ratio assessment. Discovery. 2018;54(275):442-446.

ISSN: 2278–5469.

EISSN:2278–5450.

Arthur N. Chuemere, Paul C. Akangbou, Ogadinma Ilochi. Evaluation and predictor ratio of toxicity of aluminium-tainted water impact male rats: Oxidative stress in heart and kidney. Science & Technology. 2018;4:183-188.

ISSN 2394–3750, EISSN 2394–3769.

Ilochi ON, Chuemere AN, Olorunfemi OJ, Amah-Tariah FS. Evaluation of pharmacognostic, nutraceutic and phytotherapeutic constituents of unripe Musa sapientum hydromethanolic extracts. Journal of Phytopharmacology. 2021;10(3):156-161.

Ilochi Ogadinma, Daniel Yaro Onoja, Chuemere Arthur Nwafor. Neurodynamic Influence of Hydrocortisone on Rhinencephalic and Telencephalic Brain Areas. International Neuropsychiatric Disease Journal. 2019;13(2): 1-7. Article no.INDJ.52924 ISSN: 2321-7235, NLM ID: 101632319..

Yao HR, Liu J, Plumeri D, Cao YB, He T, Lin L, et al. Lipotoxicity in HepG2 cells triggered by free fatty acids. Am. J. Transl. Res. 2011;3: 284–291.

Sales-Campos H, Souza PR, Peghini BC, Da Silva JS, Cardoso CR. An overview of the modulatory effects of oleic acid in health and disease. Mini. Rev. Med. Chem. 2013;13:201–210.