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The analgesic activity of alcoholic extract of Cinnamomum verum bark was evaluated by injecting the hind paw with formalin and then observing the animal for nociceptive conduct in the procedure of licking and biting the limb. It has steadily remained found that two separate stages of licking and biting occur. Phase 1, a short but immediate response lasting the first 5min after the hind paw is injected; phase 2, a prolonged response starting at approximately minute11and peaking between 15 to 30min,and subsiding by 50min after the injection. Among phases 1 and 2, there is an recurrent period from minute 6 to minute 10 where little nociceptive conduct is observed. It is the orized that the two different phases represent two qualitatively distinct types of pain. Phase l is a direct stimulation of the nerve by the formalin and phase 2 is an inflammatory reaction or dorsal horn neurons induced pain.
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