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The efficacy of Hylocereus undatus fruits supplementation in hematological profile against paracetamol intoxicated freshwater fish Labeo rohita juvenile was investigated. Possible effects of Hylocereus undatus fruits were observed in a freshwater fish Labeo rohita Juveniles of test fish were treated with paracetamol and analysis in Hematological parameters including haemoglobin (Hb), white blood cell (WBC) count, Red Blood Cell (RBC) count, Packed Cell Volume (PCV), Mean corpuscular haemoglobin (MCH), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin Concentration (MCHC) were analysed. The results indicated that paracetamol treated fish had drastic hematological changes in their blood, revealing paracetamol toxicity. On supplementation of Hylocereus undatus fruits to paracetamol treated group restored the hematological parameters indicated the Hylocereus undatus fruit nullified the toxicity of paracetamol.

Hylocereus undatus fruits, Labeo rohita, hematological profile, paracetamol

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KAMATCHI, K., & RAVICHELVAN, R. (2021). EFFICACY OF Hylocereus undatus FRUITS SUPPLEMENTATION IN HEMATOLOGICAL PROFILE AGAINST PARACETAMOL INTOXICATED Labeo rohita. UTTAR PRADESH JOURNAL OF ZOOLOGY, 42(23), 186-190. Retrieved from http://mbimph.com/index.php/UPJOZ/article/view/2629
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Fent K, Weston AA, Caminada D. Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 2006;76:122–159.

Ramesh M, Anitha S, Poopal RK, Shobana C. Evaluation of acute and sub-lethal effects of chloroquine (C18H26CIN3) on certain enzymological and histo-pathological biomarker responses of a freshwater fish Cyprinus carpio. Toxicol. Rep. 2018;5:18–27.

Corcoran J, Winter MJ, Tyler CR. Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects infish. Crit. Rev. Toxicol. 2010;40:287– 304.

Liao PH, Hwang CC, Chen TH, Chen PJ. Developmental exposures to wa-terborne abused drugs alter physiological function and larval locomotion in early life stages of medaka fish. Aquat. Toxicol. 2015;165:84–92.

Mottaleb MA, Stowe C, Johnson DR, Meziani MJ, Mottaleb MA. Pharmaceuticals in grocery market fish fillets by gas chromatography-mass spectrometry. Food Chem. 2016;190:529–536.

Ramaswamy BR, Shanmugam G, Velu G, Rengarajan B, Joakim Larsson DG. GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parables in Indian rivers. J. Hazard. Mater. 2011;186(2–3):1586–1593.

Shanmugam G, Sampath S, Selvaraj KK, Larsson DG, Ramaswamy BR. Nonsteroidal anti-inflammatory drugs in Indian rivers. Environ. Sci. Pollut. Res. Int. 2014;21(2):921–931.

Ghaffar FG, Naser Ashraf Tadvi K. Paracetamol Toxicity: A Review. J Cont Med A Dent. 2014;2(3):12-15.

Min EY, Kang JC. Effect of waterborne beromyl on the hematological and antioxidant parameters of the nile tilapia Oreochromis niloticus. Pestic. Biochem. Physiol. 2008;92:138-143.

Bloom JC, Brandt JT. Toxic responses of the blood. In: Casarett, L.J., Klaassen, C.D. (Eds.), Casarett and Doull’s, Toxicology: The Basic Science of Poisons. , 7th ed. McGraw-Hill Medical, New York. 2008;455–484.

Jee LH, Masroor F, Kang JC. Responses of cypermethrin induced stress in haematological parameters of Korean rockfish, Sebastes schlegeli (Hilgendorf). Aqua. Res. 2005; 36:898-905.

Kannan M, Muthusamy P, Venkatachalam U. Response of synthetic pyrethroid cypermethrin (10% EC) induced Stress in Biochemical and Hematological Parameters of Indian Major Carp Catla catla (Hamilton, 1822). World Jour. Pharmaceu. Res. 2014;3(4):1976-1996.

Akinrotimi OA, Gabriel UU, Ariweriokuma SV. Haematotoxicity of cypermethrin to African catfish Clarias gariepinus under Laboratory Conditions. Jour. Environ. Eng. Tech. 2012;1(2):20-25.

Velisek J, Stara A, Svobodova Z. The effects of pyrethroid and triazine pesticides on fish physiology. In: Stoytcheva. M., ed. Pesticides in the modern world: pests control and pesticides exposure and toxicity assessment. Rijeka: In Tech. 2011;377-402.

Henry E, Donald H, Moroan P, Simmons A. A pesticide Dieldrin induced immune haemolytic anaemia. Environ. Res. 1978;17:155.

Vani T, Saharan N, Roy SD, Ranjan R, Pal AK, Siddaiah GM, Kumar R. Alteration in haematological and biochemical parameters of Catla catla exposed to sublethal concentration of cypermethrin. Fish Physiol. Biochem. 2012;38:1577-1584.

Adhikari S, Sarkar B, Chatterjee A, Mahapatra CT, Ayyappan S. Effects of cypermethrin and carbofuran on certain hematological parameters and prediction of their recovery in a freshwater teleost, Labeo rohita (Hamilton). Ecotoxicol. Environ. Safe. 2004;58(2):220-226.

Shinde BR, Borane VR, Zambare SP. Ascorbate Effect on Endosulfan and Cypermethrin induced Alterations in The RBC of the Freshwater Fish, Channa orientalis (Scheinder). Environ. Res. Develop. 2014;8(3A):673- 675.

Masud S, Singh IJ. Temperature dependent toxicity and behavioural responses in the freshwater fish Cyprinus carpio exposed to a pyrethroid pesticide, cypermethrin. Environ. Sci. Water Res. 2013;2(10):375-381.

Saxena KK, Seth N. Toxic effects of cypermethrin on certain haematological aspects of freshwater fish Channa punctatus. Environ. Contam. Toxicol. 2002;69:364- 369.

Khatun MA, Rahman MR, Islam MS. Effects of cypermethrin and diazinon on haematology of Labeo rohita (Hamilton). Int. Jour. Develop. Res. 2014;4(5): 953-957.

Adedeji OB. Effects of diazinon on blood parameters in the African catfish (Clarias gariepinus). Afric. Jour. Biotech. 2009;8(16):3940-3946.

Anand Kumar A. Endosulfan induced biochemical and pathophysiological changes in freshwater fish, Clarias batrachus. Ph.D. Thesis, Osmania University, Hyderabad, A.P., India. 1994.

Parma MJ, Loteste A, Campana N, Bacchetta C. Changes of haematological parameters in Prochilodus lineatus exposed to sublethal concentration of cypermethrin. Jour. Environ. Biol, 2007;28:147-149.

Atamanalp M, Yanik T, Haliloglu I, Aras MS. Alterations in the haematological parameters of rainbow trout (Oncorhynchus mykiss) exposed to cypermethrin. The Israeli Jour. Aqua.-Bamid. 2002;54:99-103.

Anjusha KV, Mamun MAA, Dharmakar P, Shamima N. Effect of Medicinal Herbs on Hematology of Fishes. International Journal of Current Microbiology and Applied Sciences. 2019;8(09):2371-2376.

Kanani HG, Nobahar Z, Kakoolaki S, Jafarian H. Effect of ginger-and garlic supplemented diet on growth performance, some hematological parameters and immune responses in juvenile Husohuso. Fish Physiol Biochem. 2014;40(2):481-490.

Haghighi M, Rohani MS. The effects of powdered ginger (Zingiber officinale) on the haematological and immunological parameters of rainbow trout Oncorhynchus mykiss. J. Med. Plants Res. 2013;1(1):8-12.