ANTI-CANCER ACTIVITY OF Ganoderma lucidum MYCELIUM ALCOHOLIC EXTRACT AGAINST BREAST CANCER CELLS

Main Article Content

R. SHARMILA
K. AKILA
G. MANIGANDAN
V. JAYARAMANATHAN

Abstract

Ganoderma lucidium (Reishi) is a Mushroom that belongs to the family of Ganodermataceae, which is popularly known as “Spirit Plant”. Ganoderma lucidium has been used traditionally to treat many diseases since ancient times. Modern studies also scientifically concluded that Ganoderma lucidium has various medicinal properties like anti glycemic, antiulcer, anti-inflammatory, and anticancer, etc. This Study uses this Ganoderma lucidium extract anticancer property to be analyzed by invivo method using MCF-7 cell line and vero cell lines. G.Lucidum mycelium extract showed a significant effect on MCF-7 cell line in a concentration range between 100μg/ml to 50 μg/ml compared with the control. This G. Lucidum mycelium extract exerts high cytotoxicity in 100 μg/ml concentration againstMCF-7cell line and the IC50 values of G. Lucidum mycelium extract on the MCF-7 cell line was21.48 μg /ml. Thus, we successfully demonstrate G. Lucidum mycelium extract could be a selective anti-cancer compound with greater inhibition against human breast cancer cell line, and mild activity towards normal cells.

Keywords:
Ganoderma lucidium, MCF-7 cell line, vero cell line, anticancer activity

Article Details

How to Cite
SHARMILA, R., AKILA, K., MANIGANDAN, G., & JAYARAMANATHAN, V. (2021). ANTI-CANCER ACTIVITY OF Ganoderma lucidum MYCELIUM ALCOHOLIC EXTRACT AGAINST BREAST CANCER CELLS. UTTAR PRADESH JOURNAL OF ZOOLOGY, 42(24), 65-77. Retrieved from http://mbimph.com/index.php/UPJOZ/article/view/2658
Section
Original Research Article

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