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The Labeo rohita is a significant aquaculture freshwater species in South Asia for its rich protein and financially significant fish species which comprise about 35% of complete Indian major carps (IMCs) production in India. PTC (Pretilachlor) is a selective pre-eminent herbicide generally connected to control annual grasses and broadleaf weeds in rice field. The goal of the present examination was to research the sub-acute toxic impacts of pretilachlor on a cultivable fish Labeo rohita (L. rohita) in gill, liver and kidney. The animals were separated into four gatherings; control, Treatment I, Treatment II and Treatment III. L. rohita were exposed to PTC at a centralization of 1 mg/L (Treatment I), 3.9 mg/L (Treatment II) and 5.9 mg/L (Treatment III) for a time of 7, 14 and 21 days in gill, liver and kidney uncovered various adjustments were seen in PTC treated groups when contrasted with control groups. A noteworthy (P<0.05) diminished levels of AST and ALT was seen in PTC treated all the groups of gill, liver and kidney when contrasted with control. Similarly, enzymatic antioxidant levels also additionally diminished in gill, liver and kidney of PTC treated each of the three groups when contrasted with control. Be that as it may, LPO level was fundamentally (P<0.05) increased in gill, liver and kidney of all the three PTC treated gathering when contrasted with control with the critical (P<0.05) damages in the histology of gill, liver and kidney. Taking everything into account, PTC treatment altogether harm the all the three organ, for example, gill, liver and kidney by means of its intense ROS interceding poisonous quality in fish L. rohita.
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