Published: 2020-07-03

Page: 21-27


Department of Mathematics and Statistics, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, India.


Department of Zoology and Environmental Science, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, India.

*Author to whom correspondence should be addressed.


SARS-CoV-2 belongs to the betacoronavirus genus. Betacoronaviruses infect mammals, are zoonotic pathogens, and can cause severe respiratory disease in human being. Till date there are no drugs or vaccine to control the infection of this pandemic disease. The present comprehensive review is therefore an effort to give detailed information about Allium sativum (Garlic) against nCoronavirus. The ayurveda and other traditional system of medicine in India described garlic and other medicinal herbs are used against various epidemics time-to-time. Alternatively, a number of literature noted that compounds extracted from garlic and other group of alliums such as allicin, diallytrisulfide, azoene and quercetin exhibit antiviral activity.

Keywords: Virus, COVID-19, Allium sativum, Ayurveda, garlic

How to Cite

KAUSHIK, H., & SINGH, V. K. (2020). MATHEMATICS OF COVID-19 IN INDIA AND THEIR POSSIBLE CONTROL BY Allium sativum (L.). Asian Journal of Advances in Medical Science, 2(1), 21–27. Retrieved from


Download data is not yet available.


Cobey S. Modeling infectious disease dynamics. Science; 24 April, 2020.

DOI: 10.1125/science.abb5659

World Health Organization "WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020".

Available:, 11-march-2020

Neher RA, Dyrdak V, Druelle EB, Hodcroft J. Potential impact of seasonal forcing on a SARS-CoV-2 pandemic. Swiss Med Wkly; 2020. DOI: 10.4414/smw.2020.20224

Lu R, Zhao X, Li J, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. The Lancet. Published Online January 29, 2020.

Available: S0140-6736(20)30251-8

Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol. 2015;1282: 1–23.


Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. S0092–8674(20)30229–4 Advance Online Publication.

Singh VK, Singh DK. Pharmacological effects of Allium sativum L. (Garlic). Annual Rev Biomed Sci (ARBS). 2008;10:6-26.

Petrovska BB, Cekovska S. Extracts from the history and medical properties of garlic. Pharmacogn Rev. 2010;4(7):106-110.

Mehrbod P, Amini E, Tavassoti-Kheiri M. Antiviral activity of garlic extract on influenza virus. Iranian Journal of Virology. 2009;2(1): 1-5.

Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC. Antiviral properties of garlic: In vitro effects on influenza B, herpes simplex and coxsackie viruses. Planta Medica. 1985;5:460-461.

Weber N, Andersen D, North J, Murray B, Lawson L, Hughes B. In vitro virucidal effects of Allium sativum (Garlic) extracts and compounds. Planta Medica. 1992;58:417- 423.

Block E. The organosulfur chemistry of the genus Allium -Implication for the organic chemistry of sulfur. Angew Chem Int Ed Engl. 1992;31:1135-78.

Lawson LD. Bioactive organosulfur compound of garlic and garlic products: Role in reducing blood lipids. In: Kinghorn AD, Balandrin MF, editors. Human medicinal agents from plants. Washington: American Chemical Society. 1993;306-330.

Stoll A, Seebeck E. Über den enzymatischen Abbau des alliins und die Eigenschaften der Allinase. Helv Chim Acta. 1949;32:197-205.

Stoll A, Seebeck E. Über die spezifitat der allinase und die synthesen mehrerer dem Alliin verwandter verbindungen. Helv Chim Acta. 1949;32:866-877.

Cai XJ, Uden PC, Block E, Zhang X, Quimby BD, Sullivan JJ. Allium chemistry: Identification of natural abundance organoselenium volatiles from garlic, elephant garlic, onion and Chinese chive using headspace gas chromatography with atomic emission detection. J Agric Food Chem. 1994; 42:2081-2084.

Srivastava KC, Bordia A, Verma SK. Garlic (Allium sativum) for disease prevention. South Afr J Sci. 1995;91:68-77.

Slimestad R, Fossen T, Vagen IM. Onions: A source of unique dietary flavonoids. J Agric Food Chem. 2007;55(25):10067-80.

DOI: 10.1021/jf0712503

Shojai TM, Langeroudi AG, Karini V, Barin A, Sadri N. The effect of Allium sativum (Garlic) extract on infectious bronchitis virus in specific pathogen free embryonic egg. Avicenna J Phytomed. 2016;64:458.

Castrillo JL, Carrasco L. Action of 3-methylquercetin on polio virus RNA replication. J Virol. 1987;61(10):3319–3321.

Zandi K, Teoh BT, Sam SS, Wong PF, Mustafa MR, Abu Bakar S. Antiviral activity of four types of bioflavonoid against dengue virus type-2. Virol J. 2011;8:560.

Elena SF, Sanjuan R. adaptive value of high mutation rates of RNA viruses: Separating causes from consequences. J of Virology. 2005;79:11555-11558.

Sharma N. Efficacy of garlic and onion against virus. Int J Res Phar Sci; 2019.


Takimoto T, Taylor GL, Connaris HC, Crennell SJ, Portner A. Role of the hemagglutanin-neurominidase protein in the mechanism of paramyxovirus cell membrane fusion. J of Virology. 2002;76:13028-13033.

Wu W, Li R, Li X, He J, Jiang S, Liu S, Yang J. Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry. Viruses. 2016; 8(1):6.

Yao C, Xi C, Hu K, gao W, Cai, X Qin J, Wei Y. Inhibition of enterovirus 71 replication and viral 3C protease by quercetin. Virology J. 2018;15:116.

Chen L, Li J, Luo C, Liu H, Xu W, Chen G, Jiang H. Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV3CLpro: Structure activity relationship studies reveal salient pharmacophore features. Bioorganic & Medical Chemistry. 2006;14:8295-8306.

Gonzalez O, Fontanes V, Raychaudhuri S, Loo R, Loo J, Arumugaswami V, French SW. The heat shock protein inhibitor quercetin attenuates hepatitis C virus production. Hepatology. 2009;50:1756-1764.

D'Argenio G , Amoruso DC, Mazzone G, Vitaglione P, Romano A, Ribecco MT, D'Armiento MR, Mezza E, Morisco F, Fogliano V, Caporaso N. Garlic extract prevents CCl(4)-induced liver fibrosis in rats: The role of tissue transglutaminase. Dig Liv Dis. 2010;42(8):571-577.

Ganesan S, Faris AN, Comstock AT, Wang Q, Nanua S, Hershenson MB, Sajjan US. Quercetin inhibits rhinovirus replication in vitro and in vivo. Antiviral Res. 2012;94:258-272.