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The present study to investigate the antimicrobial activity, from rhizome fresh and dried Zingiber officinale Rosc. In the present study to observe the antibacterial activity using the microorganisms such as E. coli, Staphylococcus aureus, K. pneumoniae and Pseudomonas aeroginosa were studied by using disc diffusion method. The maximum zone of inhibition were observed in K. pneumoniae (25 mm), followed by Staphylococcus aureus (24 mm), Pseudomonas aeroginosa and E. coli each showed 22 mm. The antifungal activity carried out by using the microorganisms Aspergillus flavus, A. terreus, Penicillum sp and Fusarium sp were studied by using agar well diffusion method. The maximum zone of inhibition were observed at the concentration of 100 µg of fresh sample against Fusarium sp (14 mm) followed by A. flavus (12 mm), A. terreus (10 mm) and Penicillum sp (10 mm).
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