Tinospora cordifolia (GILOY): A MAGICAL SHRUB

Main Article Content

ARUN KUMAR SRIVASTAVA
VINAY KUMAR SINGH

Abstract

Medicinal plants have been used as natural medicines, since prehistoric times because of the presence of natural chemical constituents. Among them Tinospora cordifolia has a wide array of bioactive principles as well as it has been proven medicinally important plant, have not received considerable scientific attention. The plant is commonly used as traditional ayurvedic medicine and has several therapeutic properties such as jaundice, rheumatism, urinary disorder, skin diseases, diabetes, anemia, inflammation, allergic condition, anti-periodic, radio protective properties, etc. A special focus has been made on its health benefits in treating endocrine and metabolic disorders and its potential as an immune booster. The stem of this plant is generally used to cure diabetes by regulating level of blood glucose. T. cordifolia is well known for its immunomodulatory        response. This property has been well documented by scientists. A large variety of compounds which are responsible for immunomodulatory and cytotoxic effects are 11-hydroxymuskatone, N-methyle-2-pyrrolidone, Nformylannonain, cordifolioside A, magnoflorine, tinocordioside and syringin. Root extract of this plant has been shown a decrease in the regular resistance against HIV. The active principles from T. cordifolia enhance host immune system by increasing immunoglobulin and blood leukocyte levels and by the stimulation of stem cell proliferation. Tinospora cordifolia has been used in indigenous systems of medicine, as indicated in various classical texts of Ayurvedic System of Medicine, viz. Charak, Sushrut and Ashtang Hridaya and other ancient treaties.

Keywords:
Tinospora, alkaloids, antihyperglycemic, antimutagenic, stimulant, adaptogen.

Article Details

How to Cite
SRIVASTAVA, A. K., & SINGH, V. K. (2021). Tinospora cordifolia (GILOY): A MAGICAL SHRUB. Asian Journal of Advances in Medical Science, 3(3), 22-30. Retrieved from https://mbimph.com/index.php/AJOAIMS/article/view/2086
Section
Review Article

References

Mittal J, Sharma MM, Batra A. Tinospora cordifolia: A multipurpose medicinal plant- A review. Journal of Medicinal Plants Studies. 2014;2(2):32-47.

Kumar DV, Geethanjali B, Avinash KO, et al. Tinospora cordifolia: The antimicrobial property of the leaves of amruthaballi. J Bacteriol Mycol Open Access. 2017;5(5):363-371.

Sofowora A, Ogunbodede E, Onayade A. The role and place of medicinal plants in the strategies for disease prevention. Afr J Tradit Complement Altern Med. 2013;10(5):210–229.

Tungmunnithum D, Thongboonyou A, Pholboon A, Yangsabai A. Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: An overview. Medicines (Basel). 2018;5(3):93.

Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2(5):270–278.

Ekor M. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2013;4:177.

Yuan H, Ma Q, Ye L, Piao G. The traditional medicine and modern medicine from natural products. Molecules. 2016;21(5): 559.

Sharma P, Dwivedee BP, Bisht D, Dash AK, Kumar D. The chemical constituents and diverse pharmacological importance of Tinospora cordifolia. Heliyon. 2019;5(9): e02437.

Tripathi BM, Singh DC, Chaubey S, Kour1 G, Arya R. A critical review on guduchi (Tinospora cordifolia (willd.) miers) and its medicinal properties. Int. J. Ayur. Pharma Research. 2015;3(5):6-12.

Khan MM, Haque MS, Islam M. S. Chowdhury. Medicinal use of the unique plant Tinospora Cordifolia: Evidence from the traditional medicine and recent research. Asian J. Med. Biol. Res. 2016;2(4):508-512.

Tiwari P, Nayak P, Prusty SK, Sahu PK. Phytochemistry and pharmacology of Tinospora cordifolia: A review. Sys Rev Pharm. 2018;9(1):70-78.

Saha S, Ghosh S. Tinospora cordifolia: One plant, many roles. Anc Sci Life. 2012;31(4):151–159.

Dhama K, Sachan S, Khandia R, Munjal A, Iqbal HMN, Latheef SK, et al. Medicinal and beneficial health applications of Tinospora cordifolia(Guduchi): A miraculous herb countering various diseases/disorders and its immunomodulatory effects. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery. 2016;10:96-111.

Gupta BM, Ahmed KKM, Gupta R. Global research on Tinospora cordifolia (Medicinal Plant) with special reference to India: A scientometric assessment publications output during 2001-2016. Int J Pharmacogn Chinese Med. 2018;2(4):000141.

Singh A, Saxena S, Babu A. A pharmacological and chemical constituents review on Tinospora cordifolia -a medicinal herb. World Journal of Pharmaceutical Research. 2020;9(14):472-491.

Joladarashi D, Chilkunda ND, Salimath PV. Glucose uptake-stimulatory activity of Tinospora cordifolia stem extracts in Ehrlich ascites tumor cell model system. J Food Sci Technol. 2014;51(1):178–182.

Salehi B, Ata A, Kumar NVA, Sharopov F, Alarcón KR, Ortega AR, Ayatollahi SA, et al. Antidiabetic potential of medicinal plants and their active components. Biomolecules. 2019;9(10):551.

Srivastava S, Lal VK, Pant KK. Polyherbal formulations based on Indian medicinal plants as antidiabetic phytotherapeutics. Phytopharmacology. 2012;2(1):1-15.

Chougale AD, Ghadyale VK, Panaskar SN, Arvindekar AU. Alpha glucosidase inhibition by stem extract of Tinospora cordifolia. J Enzyme Inhib Med Chem. 2009;24(4):998-1001.

Sharma R, Amin H, Galib, Prajapati PK. Antidiabetic claims of Tinospora cordifolia (Willd.) Miers: Critical appraisal and role in therapy. Asian Pacific Journal of Tropical Biomedicine. 2015;5(1):68-78.

Krishna K, Jigar B, Jagruti P. Guduchi (Tinospora cordifolia): Biological and medicinal properties, a review. The Internet Journal of Alternative Medicine. 2008;6(2).

Manaharan T, Palanisamy UD, Ming CH. Tropical plant extracts as potential antihyperglycemic agents. Molecules. 2012;17(5):5915–5923.

Reddy SS, Ramatholisamma P, Karuna R, Saralakumari D. Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats. Food Chem Toxicol. 2009;47(9): 2224-9.

Khedekar SB, Ravishankar B, Prajapati PK. Anti-diabetic activity of dried extract of Tionspora cordifolia (Guduchi ghana) and honey in streptozotacin induced diabetic rats. International Journal of Green Pharmacy. 2015;9(4):S31.

Sharma U, Bala M, Kumar N, Singh B. Immunomodulatory active compounds from Tinospora cordifolia. Journal of Ethnopharmacology. 2012;141(3):918-926.

Anusha G, Sailaja AK. An overall review on Tinospora cordifolia. Experimental Medicine. 2020;2(1).

Rawat H, Sharma M, Sharma S. T. cordifolia: A medicinal plant. International Journal of Chemical Studies. 2020;8(3):40-43.

Alsuhaibani S, Khan MA. Immune-stimulatory and therapeutic activity of Tinospora cordifolia: Double-edged sword against salmonellosis. J Immunol Res. 2017;1787803.

Gupta PK, Chakraborty P, Kumar S, Singh PK, Rajan MGR, Sainis KB, Kulkarni S. G1-4A, a polysaccharide from Tinospora cordifolia inhibits the survival of Mycobacterium tuberculosis by modulating host immune responses in TLR4 dependent manner. PLoS One. 2016;11(5):e0154725.

Reddy NM, Reddy RN. Tinospora cordifolia chemical constituents and medicinal properties: A review. Sch. Acad. J. Pharm. 2015;4(8):364-369.

Gupta R, Sharma V. Ameliorative effects of Tinospora Cordifolia root extract on histopathological and biochemical changes induced by aflatoxin-B1 in mice kidney. Toxicol Int. 2011;18(2):94–98.

Sharma V, Pandey D. Protective role of Tinospora cordifolia against lead-induced hepatotoxicity. Toxicol Int. 2010;17(1):12-7.

Promila Singh S, Devi P. Pharmacological potential of Tinospora cordifolia (Willd.) Miers ex hook. & Thoms. (Giloy): A review. Z Journal of Pharmacognosy and Phytochemistry. 2017;6(6):1644-1647.

Dissanayake KGC, Perera WPRT, Premasinghe N. Immunomodulatory efficiency of Tinospora cordifolia against viral infections. World Journal of Pharmaceutical and Medical Research. 2020;6(5):22-28.

Singh S. Magical ayurvedic spices and herbs that can boost our immunity. MOJ Food Process Technols. 2020;8(3):99‒102.

Kumar D, Ojha NK. Study of morbidity status in children and the effect of Guduchi Syrup as an immunomodulator for lowering down the morbidity rate. Journal of Ayurveda and Integrated Medical Sciences. 2018;3(2).

Kumar D, Ojha N, Londhe JD. Ayurvedic drugs in lowering the morbidity and mortality in children-a short review. Vaidyan. 2016;1:18–25.

Patel D, Mansoori AN. Cancer—an Ayurvedic perspective. IJARPB, 2012;2(2):179-195.

Jagetia GC, Rao SK. Evaluation of cytotoxic effects of dichloromethane extract of Guduchi (Tinospora cordifolia Miers ex Hook F & THOMS) on cultured He La cells. eCAM. 2006;3(2):267–272.

Ali H, Dixit S. Extraction optimization of Tinospora cordifolia and assessment of the anticancer activity of its alkaloid palmatine. Scientific World Journal. 2013;28:376216.

Verma R, Chaudhary HS, Agrawal RC. Evaluation of anticarcinogenic and antimutagenic effect of Tinospora cordifolia in experimental animals. Chem. Pharm. Res. 2011;3(6):877-881.

Mishra R, Kaur G. Aqueous ethanolic extract of Tinospora cordifolia as a potential candidate for differentiation based therapy of glioblastomas. PLoS One. 2013;8(10):e78764.

Sharma T, Rawal G. Role of ayurveda in tumorigenesis: A brief review. Int J Green Pharm. 2012;6:93-101.

Pratihast K, Kumar R, Bharti SK. Comparative antimicrobial activity of ethanolic and aqueous extract of Tinospora cordifolia. ~ 129~The Pharma Innovation Journal. 2019;8(3):129-136.

Chakraborty B, Nath A, Saikia H, Sengupta M. Bactericidal activity of selected medicinal plants against multidrug resistant bacterial strains from clinical isolates. Asian Pac J Trop Med. 2014;7(Suppl 1):S435- S441.

Agarwal S, Ramamurthy PH, Fernandes B, Rath A, Sidhu P. Assessment of antimicrobial activity of different concentrations of Tinospora cordifolia against Streptococcus mutans: An in vitro study. Dent Res J (Isfahan). 2019;16(1):24–28.

Shanthi V, Nelson R. Anitbacterial activity of Tinospora cordifolia (Willd) Hook. F. Thoms on urinary tract pathogens. Int. J. Curr. Microbiol. App. Sci. 2013;2(6):190-194.

Singh K, Panghal M, Kadyan S, Chaudhary U, Yadav JP. Green silver nanoparticles of Phyllanthus amarus as an antibacterial agent against multi drug resistant clinical isolates of Pseudomonas aeruginosa. Journal of Nanobiotechnology. 2014;12:40.

Prajwala B, Priyanka S, Raghu N, Gopenath N, Gnanasekaran A, Karthikeyan M, et al. In vitro anti-bacterial activity of Tinospora cordifolia leaf extract and its phytochemical screening. Journal of Biomedical Sciences. 2018;5(2):10-17.

Khan MA. Tinospora cordifolia aqueous extract ameliorates the systemic infection of Aspergillus fumigatus in Balb/c mice. Asian J Pharm Clin Res. 2019;12(3):525-528.

Prasad B, Chauhan A. Anti-oxidant and antimicrobial studies of Tinospora cordifolia (Guduchi/Giloy) stems and roots under In vitro condition. Int. J. Adv. Microbiol. Health. Res. 2019;3(1):1-10.

Upadhyay N, Ganie SA, Agnihotri RK, Sharma R. Studies on antioxidant activity and total phenolic content of Tinospora cordifolia (Miers.) stem using in vitro models. American Journal of Phytomedicine and Clinical Therapeutics. 2013;18:617-627.

Sivakumar V, Rajan MSD. Antioxidant effect of Tinospora cordifolia extract in Alloxan-induced diabetic rats. Indian J. Pharm. Sci. 2010;72(6):795-798.

Upadhyay N, Ganie SA, Agnihotri RK, Sharma R. Free radical scavenging activity of Tinospora cordifolia (Willd.) Miers. Journal of Pharmacognosy and Phytochemistry. 2014;3(2):63-69.

Sengupta S, Mukherjee A, Goswami R, Basu S. Hypoglycemic activity of the antioxidant saponarin, characterized as alpha-glucosidase inhibitor present in Tinospora cordifolia. J Enzyme Inhib Med Chem. 2009;24(3):684-90.

Upadhyay AK, Kumar K, Kumar V, Mishra HS.. Tinospora cordifolia (Willd.) Hook. f. and Thoms. (Guduchi) – validation of the Ayurvedic pharmacology through experimental and clinical studies. Int J Ayurveda Res. 2010;1(2):112–121.

Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: Current state. Nutr J. 2016;15:71.

Altemimi A, Lakhssassi N, Baharlouei A, Watson DG, Lightfoot DA. Phytochemicals: Extraction, isolation and identification of bioactive compounds from plant extracts. Plants (Basel). 2017;6(4):42.

Kulkarni R, Girish KJ, Kumar A. Nootropic herbs (Medhya Rasayana) in Ayurveda: An update. Pharmacogn Rev. 2012;6(12):147–153.

Kalikar MV, Thawani VR, Varadpande UK, Sontakke SD, Singh RP, Khiyani RK. Immunomodulatory effect of Tinospora cordifolia extract in human immuno-deficiency virus positive patients. Indian J Pharmacol. 2008;40(3):107–110.

Prince PSM, Menon, VP, Gunasekaran G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol. 1999;64(1):53-7.

Sharma B, Dabur R. Protective effects of Tinospora cordifolia on hepatic and gastrointestinal toxicity induced by chronic and moderate alcoholism. Alcohol Alcohol. 2016;51(1):1-10.

Hashilkar NK, Patil PA, Bagi JG, Patil SY, Angadi NB. Influence of Tinospora cordifolia on wound healing in wistar rats. Int J Basic Clin Pharmacol. 2016;5(3):923-928.

Badar VA, Thawani VR, Wakode PT, Shrivastava MP, Gharpure KJ, Hingorani LL, Khiyani RM. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol, 2005;96(3):445-449.

Rajalakshimi V, Gauthaman K, Alhazzani AA, Kamalraj K, Nisar N, Devdass G. Analgesic and anti-inflammatory evaluation of ethanolic extract of Seenthil churanam. International Journal of Pharmaceutical Sciences and Drug Research. 2015;7(1):63-67.

Malve HO, Raut SB, Marathe PA, Rege NN. Effect of combination of Phyllanthus emblica, Tinospora cordifolia and Ocimum sanctum on spatial learning and memory in rats. J Ayurveda Integr Med. 2014;5(4):209–215.