Assessment of Human Papillomavirus Infection, Knowledge and Attitude among Women Infected with HIV in Minna, Niger State, Nigeria

PDF Review History

Published: 2024-04-29

Page: 68-78


Sylvanus, I. Ezra

Department of Applied Biology and Biotechnology, Enugu State University of Science and Technology, P.M.B. 1660, Enugu, Nigeria.

Victor Stephen Njom *

Department of Applied Biology and Biotechnology, Enugu State University of Science and Technology, P.M.B. 1660, Enugu, Nigeria.

*Author to whom correspondence should be addressed.


Abstract

Human Papillomavirus (HPV) is a debilitating sexually transmitted infection. Global in occurrence but common in developing countries. This study investigated the prevalence of Human Papillomavirus (HPV) infection among HIV-positive women attending gynaecological appointments at Minna General Hospital in Niger State, Nigeria and assessed their knowledge of HPV and attitudes toward HPV screening. The research involved 162 eligible participants who underwent HPV testing. A structured questionnaire was used for data collection and gynaecological examinations were conducted to obtain cervical cell samples, which were then processed and subjected to HPV testing using the Riatol quantitative PCR HPV genotyping test. The study revealed that 74% of the participants tested positive for HPV, with 41% having high-risk HPV (HrHPV) and 33% low-risk HPV (LrHPV). Despite elevated risk status, participants exhibited limited knowledge about HPV, with only 4% being aware of its link to cervical cancer, and 5% knowing about HPV vaccines. Encouragingly, 60% of participants had undergone HPV screening in the past five years, and 75% expressed willingness to undergo routine HPV screening if they were to collect the samples themselves (self-sampling). for HPV screening. The high prevalence of HPV, particularly the high-risk types, underscored the significance of HPV screening among HIV-positive women. However, participants showed a strong commitment to proactive healthcare behaviours. Collaborations with healthcare professionals and media outlets are recommended to enhance public awareness of HPV and its association with cervical cancer, ultimately reducing the burden of HPV-related diseases among this population.

Keywords: Prevalence, human papilloma virus, knowledge and attitude, HIV, women


How to Cite

Ezra, S. I., & Njom , V. S. (2024). Assessment of Human Papillomavirus Infection, Knowledge and Attitude among Women Infected with HIV in Minna, Niger State, Nigeria. Asian Journal of Advances in Medical Science, 6(1), 68–78. Retrieved from https://mbimph.com/index.php/AJOAIMS/article/view/4059

Downloads

Download data is not yet available.

References

Jee, Babban, Renu Yadav, Sangeeta Pankaj, Shivendra Kumar Shahi. Immunology of HPV-mediated cervical cancer: Current understanding. International Reviews of Immunology. 2021;40(5):359–78.

Lee, Hee Yun, Yan Luo, Jessica Neese, Casey Daniel, Hyeouk Chris Hahm. The role of English proficiency in hpv and hpv vaccine awareness: A cross-sectional study across race/ethnicity. Asian Pacific Journal of Cancer Prevention: APJCP 2021.22(2):349.

Lee, Jeongim, and Hae Kyoung Son. Comparison of learning transfer using simulation problem-based learning and demonstration: An application of papanicolaou smear nursing education. International Journal of Environmental Research and Public Health. 2021;18(4):1765.

Kloku, Catherine Akorfa. Awareness and Prevention of Cervical Cancer among Female Health Professionals: A Study of 3 Health Institutions in Winneba, Ghana; 2015.

Crosbie, Emma J, Mark H Einstein, Silvia Franceschi, Henry C. Kitchener. Human papillomavirus and cervical cancer. The Lancet. 2013; 382(9895):889–99.

Okunade, Kehinde Sharafadeen. Human papillomavirus and cervical cancer. Journal of Obstetrics and Gynaecology. 2020;40(5):602–8.

Walboomers, Jan MM, Marcel V, Jacobs M, Michele Manos F, Xavier Bosch J, Alain Kummer Keerti V, Shah Peter JF Snijders, Julian Peto, Chris JLM Meijer, Nubia Muñoz. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. The Journal of Pathology. 1999; 189(1):12–19.

Xing, Biyuan, Jianfeng Guo, Yuhan Sheng, Gang Wu, Yingchao Zhao. Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review. Frontiers in Oncology. 2021; 10:606335.

Stanley, Margaret. Immune responses to human papillomavirus and the development of human papillomavirus vaccines. In Human Papillomavirus. Elsevier. 2020;283–97.

Ashaka, Oluwaseyi Sedowhe, Adesuyi Ayodeji Omoare, Ayorinde Babatunde James, Oluwapelumi Olufemi Adeyemi, Femi Oladiji, Kayode Adebamiji Adeniji, Kehinde Sharafadeen Okunade, Olajide Olubunmi Agbede. Prevalence and risk factors of genital human papillomavirus infections among women in Lagos, Nigeria. Tropical Medicine and Infectious Disease. 2022;7(11):386.

Zehra, SAFI. General characteristics of human papilloma virus (HPV) and it’s interaction with the cell cycle. Theory and Research in Health Sciences; 2022.

Nyam, Chuwang Jacob. Distribution of Human Papillomavirus Genotypes among Women with Cervical Cancer in Nigeria; 2023.

McBride, Alison A. Human papillomaviruses: Diversity, infection and host interactions. Nature Reviews Microbiology. 2022; 20(2): 95–108.

Bruni, Laia, Ginesa Albero, Jane Rowley, Laia Alemany, Marc Arbyn, Anna R Giuliano, Lauri E. Markowitz, Nathalie Broutet, and Melanie Taylor. Global and regional estimates of genital human papillomavirus prevalence among men: A systematic review and meta-analysis. The Lancet Global Health. 2023; 11(9):e1345–62.

Giannone, Gaia, Anna R Giuliano, Marco Bandini, Laura Marandino, Daniele Raggi, Wayne Earle, Benjamin Ayres, Curtis A Pettaway, Iain A Mc Neish, Philippe E Spiess. HPV vaccination and HPV-related malignancies: Impact, strategies and optimizations toward global immunization coverage. Cancer Treatment Reviews. 2022;111: 102467.

Ntuli, Lungelo, Andile Mtshali, Gugulethu Mzobe, Lenine JP Liebenberg, Sinaye Ngcapu. Role of immunity and vaginal microbiome in clearance and persistence of human papillomavirus infection. Frontiers in Cellular and Infection Microbiology. 2022;12:927131.

Faye, Babacar, Fatimata Diallo, Hameth Sarr, Pape Mbacké Sembene, Alioune Dièye. Scholars Academic Journal of Biosciences; 2020.

Kabuga, Auwal Idris, Ahmad Nejati, Amanuel Godana Arero, Somayeh Jalilvand, Talat Mokhtari-Azad, Shirin Shahbazi Sighaldeh, Umma Hassan Wali, Shohreh Shahmahmoodi. Prevalence and type distribution of human papillomavirus recovered from the uterine cervix of Nigerian women: A systematic review and meta-analysis. Asian Pacific Journal of Cancer Prevention: APJCP. 2020; 21(10):2837.

Ferreira, Matthew Thomas, Milena Giulia Gonçalves, Rossana Veronica Mendoza López, Laura Sichero. Genetic variants of hpv-16 and their geographical and anatomical distribution in men: A systematic review with meta-analysis. Virology. 2021;558: 134–44.

Huang, Junjie, Yunyang Deng, Daniel Boakye, Man Sing Tin, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno III, Wanghong Xu, Zhi-Jie Zheng, and Edmar Elcarte. Global distribution, risk factors, and recent trends for cervical cancer: A worldwide country-level analysis. Gynecologic Oncology. 2022; 164(1):85–92.

Kelly HA. The Epidemiology of Human Papillomavirus (HPV) Infection and Epigenetic Factors Associated with the Development of Cervical Cancer Precursor Lesions in Women Living with HIV in Africa; 2017.

Ren, Hui-Ming, Min-Qi Liao, Si-Xian Tan, Chen Cheng, Sui Zhu, Lu Zheng, Jun-Rong Ma, Ying-Jun Mu, Wan-Lin Li, and Shi-Wen Zhang. 2022. Global, Regional, and National Burden of Cancer in Children Younger Than 5 Years, 1990–2019: Analysis of the Global Burden of Disease Study. Frontiers in Public Health. 2019; 10:910641.

Onwuamah, Chika Kingsley, Ning Feng, Abidemi Esther Momoh, Mabel Uwandu, Rahaman Ademolu Ahmed, Ifeoma Idigbe, Grace Deborah Vincent, Chinenye Angela Ogbu, Nkem Okonkwo, Judith Sokei, Bowofoluwa Sharon Abimbola, Temiloluwa Ojopagogo, Leona Chika Okoli, Mary Adesina, Priscilla Ngozi Ezemelue, Omowunmi Sowunmi, Jane Okwuzu, Olaoniye Habeebat Labo−Popoola, Joseph Ojonugwa Shaibu, Greg Aigbe Ohihoin, Emily Nzeribe, Agatha David, Olufemi Olaleye, Ighovwerha Ofotokun, Xiao−ping Dong, and Oliver Chukwujekwu Ezechi. Prevalence and Risk Factors for High-Risk Human Papillomavirus Infection among Women from Three Southern Geopolitical Zones of Nigeria. Frontiers in Oncology. 2023;13.

Jalil, Alattabi Abduladheem Turki nd. Epidemiology of Cervical Cancer and High Risk of Human Papilloma Virus in Patient. BBK 28.6 Z 85(7).

Paula Almeida Cunha, Ana, Ilka Kassandra Pereira Belfort, Francisco Pedro Belfort Mendes, Gerusinete Rodrigues Bastos dos Santos, Lucas Henrique de Lima Costa, Pablo de Matos Monteiro, Renata Lemos Gaspar, Mariele Borges Ferreira, Alice de Sá Ferreira, and Sally Cristina Moutinho Monteiro. Human papillomavirus and its association with other sexually transmitted coinfection among sexually active women from the northeast of Brazil. Interdisciplinary Perspectives on Infectious Diseases; 2020.

Akbari, Elahe, Alireza Milani, Masoud Seyedinkhorasani, Azam Bolhassani. HPV co‐infections with other pathogens in cancer development: A comprehensive review. Journal of Medical Virology. 2023; 95(11): e29236.

Wierzbicka, Malgorzata, Jens Peter Klussmann, Michel R San Giorgi, Nora Wuerdemann, Frederik G Dikkers. Oral and Laryngeal HPV Infection: Incidence, Prevalence and Risk Factors, with Special Regard to Concurrent Infection in Head, Neck and Genitals. Vaccine. 2021;39(17): 2344–50.

Nejo, YT, DO Olaleye, GN Odaibo. Prevalence and risk factors for genital human papillomavirus infections among women in southwest Nigeria. Archives of Basic and Applied Medicine. 2018;6(1): 105.

Giannone, Gaia, Anna R Giuliano, Marco Bandini, Laura Marandino, Daniele Raggi, Wayne Earle, Benjamin Ayres, Curtis A Pettaway, Iain A Mc Neish, Philippe E Spiess. HPV vaccination and HPV-related malignancies: Impact, strategies and optimizations toward global immunization coverage. Cancer Treatment Reviews. 2022;111: 102467.

Ghebre Rahel G, Surbhi Grover, Melody J Xu, Linus T Chuang, Hannah Simonds. Cervical cancer control in HIV-infected women: Past, present and future. Gynecologic Oncology Reports. 2017;21:101–8.

Shinde S, Vishvakarma NK, Tiwari AK, Dixit V, Saxena S, Shukla D. Therapeutic options for the management of cervical cancer. In a Theranostic and Precision Medicine Approach for Female-Specific Cancers. Elsevier. 2021;193–212.

McBride, Kimberly R, Shipra Singh. Predictors of adults’ knowledge and awareness of hpv, hpv-associated cancers, and the HPV vaccine: Implications for health education. Health Education and Behavior. 2018;45(1):68–76.

Stephens, Erica S, Emily Dema, Jennifer K, McGee-Avila, Meredith S Shiels, Aimée R Kreimer, Jaimie Z Shing. Human Papillomavirus Awareness by Educational Level and by Race and Ethnicity. JAMA Network Open. 2023;6(11): e2343325–e2343325.

Le, Daisy, Hee Jun Kim, Kuang-Yi Wen, Hee-Soon Juon. Disparities in awareness of the HPV vaccine and HPV-associated cancers among racial/ethnic minority populations: HINTS. Ethnicity and Health. 2023; 28(4):586–600.

Thompson Erika L, Christopher W Wheldon, Brittany L Rosen, Sarah B Maness, Monica L Kasting, Philip M Massey. Awareness and knowledge of HPV and HPV vaccination among adults ages 27–45 years. Vaccine. 2020;38(15): 3143–48.