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Published: 2022-04-13

Page: 719-732


Department of Physiology, Biochemistry and Pharmacology, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram-4225, Bangladesh.


Department of Physiology, Biochemistry and Pharmacology, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram-4225, Bangladesh.


Department of Physiology, Biochemistry and Pharmacology, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram-4225, Bangladesh.


Department of Poultry Science, Sher-e-Bangla Agricultural University, Dhaka-1207, Bangladesh.


Department of Physiology, Biochemistry and Pharmacology, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram-4225, Bangladesh.

*Author to whom correspondence should be addressed.


One of the types of fat soluble vitamins, vitamin D, is a family of compounds consisting of 9-10 Secosteroids. These are classified into five different forms two of which are found naturally- vitamin D2 (photo chemically synthesized in plants) and D3 (synthesized in animal and human skin). Sources of such vitamin include dietary components and exposure to sunlight and the functions are carried out through the vitamin’s interaction with its receptors in the body as it participates in several mechanisms in the form of different analogs of itself. The aim of this review is to better understand the mechanism of the vitamin D receptors and various analogs of the vitamin D as well as its role against different types of cancers. Receptors of vitamin D have been isolated that are involved in various regulatory processes which extend beyond classic functions of the hormone like vitamin. Several analogs of this vitamin have been discovered throughout the years which have shown to have role against different types of diseases including cardiovascular, autoimmune, inflammatory diseases and most importantly, cancers. Mechanism of anticancer action of the hormone like fat soluble vitamin has also been studied and it has helped to identify a molecular link between the vitamin and prevention and regression of colorectal, prostate, breast and colon cancer as well as multiple myeloma which might lead to the conclusion that supplementation of vitamin D, in the correct amount might have a role of great importance in the prevention of cancer.

Keywords: Vitamin D, receptors, analogs, cancer

How to Cite

ALEMA, B.-N., ISLAM, S. K. M. A., KHAN, S. A., AFTABUZZAMAN, M., & FARUK, M. S. A. (2022). BIOCHEMISTRY OF VITAMIN D AND ITS ROLE AGAINST CANCER. Asian Journal of Advances in Research, 5(1), 719–732. Retrieved from


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Mellanby E. An experimental investigation on rickets. The Lancet. 2009;34(11):407–412.

Bouillon R, Eelen G, Verlinden L, Mathieu C, Carmeliet G, Verstuyf A. Vitamin D and cancer. The Journal of Steroid Biochemistry and Molecular Biology. 2006; 102(1): 156-162.

Göring H. Vitamin D in nature: a product of synthesis and/or degradation of cell membrane components. Biochemistry (Moscow). 2018;83(11): 1350-1357.

Satyanarayana U. Biochemistry. Elsevier Health Sciences. 2013;6:34-40.

Wimalawansa SJ. Biology of vitamin D. Journal of Steroids and Hormonal Science. 2019;10(198): 2-8.

Johnson JA, Kumar R. Vitamin D and renal calcium transport. Current Opinion in Nephrology and Hypertension. 1994;3(4): 424-429.

Moukayed M, Grant WB. Molecular link between vitamin D and cancer prevention. Nutrients, 2013;5(10): 3993-4021.

Spina CS, Tangpricha V, Uskokovic M, Adorinic L, Maehr H, Holick MF. Vitamin D and cancer. Anticancer Research. 2006;26(4): 2515-2524.

Chen J, Tang Z, Slominski AT, Li W, Żmijewski MA, Liu Y, Chen J. Vitamin D and its analogs as anticancer and anti-inflammatory agents. European Journal of Medicinal Chemistry. 2020;207: 112738.

Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Rheumatic Disease Clinics. 2012;38(1): 1-11.

Lin Z, Li W. The roles of vitamin D and its analogs in inflammatory diseases. Current Topics in Medicinal Chemistry. 2016;16(11): 1242-1261.

Mitchell RN. The relationship between vitamin D and cancer. Clinical Journal of Oncology Nursing. 2011;15(5): 557.

Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacological Reviews. 2006;58:742-759.

Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nature Reviews. 2014;14: 342-357.

Pike JW, Meyer MB, Bishop KA. Regulation of target gene expression by the vitamin D receptor - an update on mechanisms. Reviews in Endocrine & Metabolic Disorders. 2012;13: 45-55.

Barbáchano A, Fernández-Barral A, Ferrer-Mayorga G, Costales-Carrera A, Larriba MJ, Muñoz A. The endocrine vitamin D system in the gut. Molecular and Cellular Endocrinology. 2017; 453: 79-87.

Bakke D, Sun J. Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation. Inflammatory Bowel Diseases. 2018;24: 1149-1154.

Al-Ghafari AB, Balamash KS, Doghaither HA. Serum vitamin D receptor (VDR) levels as a potential diagnostic marker for colorectal cancer. Saudi Journal of Biological Sciences. 2020;27: 827-832.

Maestro MA, Molnar F, Mourino A, Carlberg C. Vitamin D receptor: novel ligands and structural insights. Expert Opinion on Therapeutic Patents. 2016;28: 1291- 1306.

Weyts FA, Dhawan P, Zhang X, Bishop JE, Uskokovic MR, Ji Y, Christakos, S. Novel Gemini analogs of 1α, 25-dihydroxyvitamin D3 with enhanced transcriptional activity. Biochemical Pharmacology. 2004;67(7): 1327-1336.

Chakraborti CK. Vitamin D as a promising anticancer agent. Indian Journal of Pharmacology. 2011;43(2): 113.

Vuolo L, Faggiano A, Colao AA. Vitamin D and cancer. Frontiers in Endocrinology. 2012;3: 58.

Ali MM, Vaidya V. Vitamin D and cancer. Journal of Cancer Research and Therapeutics. 2007;3(4): 225.

Zhao X, Feldman D. Regulation of vitamin D receptor abundance and responsiveness during differentiation of HT-29 human colon cancer cells. Endocrinology. 1993;132(4): 1808-1814.

Barreto DV, Barreto FC, Liabeuf S, Temmar M, Boitte F, Choukroun G, Massy ZA. Vitamin D affects survival independently of vascular calcification in chronic kidney disease. Clinical Journal of the American Society of Nephrology. 2009;4(6): 1128-1135.

Garland CF, Garland FC. Do sunlight and vitamin D reduce the likelihood of colon cancer? International Journal of Epidemiology. 2006;35(2): 217-220.

Zinser GM, Welsh J. Accelerated mammary gland development during pregnancy and delayed post lactational involution in vitamin D3 receptor null mice. Molecular Endocrinology. 2004;18(9):2208-2223.

Chu E, Sartorelli AC. Cancer chemotherapy. In: Katzung BG, editor. Basic and clinical pharmacology. 10th ed. Boston: McGraw-Hill. 2007:878-907.

Kostoglou AI, Athanassiou L, Athanassiou P. Vitamin D and Autoimmune Diseases. In Vitamin D Deficiency. Intech Open. 2019; 1-18.