Published: 2021-12-23

Page: 619-628


Invertis University., NH-24, Bareilly-243123 UP, India.


Department of Biotechnology, Invertis University, NH-24, Bareilly-243123 UP, India.


Rohilkhand Laboratory and Research Centre, B-4, Parsakhera Industrial Area-243502 UP, India.

*Author to whom correspondence should be addressed.


Tras-resveratrol gained popularity since it was reported to be associated with its antiaging effect. Many sources are reported to have resveratrol. Peanut (Arachis hypogaea) is also one of them that produces trans-resveratrol, a compound with various biological properties like antioxidant, anticancer, and anti-inflammatory effects as well. In many studies, trans-resveratrol was detected in the roots, leaves, and stems and purple seed coats of peanuts cultivated in a sterile environment. Generally, peanut produces not much amount of resveratrol but when the peanut plant faces biotic stress, it produces enough amount of trans-resveratrol. This resveratrol may be detected by reverse-phase HPLC. The various experiments conducted on the culture of Saccharomyces cerevisiae showed a positive result as far as the antiaging effect is concerned. The promising results obtained during experiments promoted various pharmaceutical companies to synthesize and sell in the form of plant extract. Slowly, trans-resveratrol has gained good market value as an antiaging product. It has been a long journey since 2000 when the very first time trans-resveratrol came into existence as an antiaging compound and yeast was the biological model. Since then various model organisms were selected to finally reach human trials. But still, the exact pathway is not clear, therefore, it is imperative to study different model organisms. Although in recent past, many human trials have been reported and the result was also astonishing. In the current scenario, various human trials are going on but no antiaging project on humans has been reported. This review encourages more researches to see the antiaging effects of trans-resveratrol.

Keywords: DNA methylation, sirt, biological age, NAD, histone deacetylase, chronological age

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