AN OVERVIEW OF THE TRADITIONAL USES, PHYTOCHEMICAL CONSTITUENTS, PHARMACOLOGICAL AND TOXICOLOGICAL ASPECTS OF PERSICARIA HYDROPIPER (L.) DELARBRE

PDF

Published: 2022-02-27

DOI: 10.56557/upjoz/2022/v43i32924

Page: 71-85


ANJUMANI OJAH *

Department of Zoology, Gauhati University, Guwahati-781014, Assam, India.

MRIDUL KR. BORTHAKUR

Department of Zoology, B. Borooah College, Guwahati-781007, Assam, India.

JOGEN CH. KALITA

Department of Zoology, Gauhati University, Guwahati-781014, Assam, India.

*Author to whom correspondence should be addressed.


Abstract

Persicaria hydropiper (L.) Delarbre, an annual herb of the family polygonaceae, locally known as Patharua bihalagani in Assam (India), is reported as a traditional drug for birth control used by women in some parts of Assam. The current study presents the taxonomical description, geographical distribution, traditional uses, phytochemical composition, pharmacological and toxicological activities of P. hydropiper. The whole plant or part(s) like leaves, stems root etc have been traditionally used as herbal medicine for treatment of various ailments. Several bioactive components such as flavonoids, phenylpropanoids, essential oils, glycosides, phytosterols and sesquiterpenes among others were reported. The extracts and phytoconstituents of P. hydropiper possess antioxidant, anti-microbial, anti-inflammatory, cytotoxic, estrogenic, antifertility, neuroprotective activities, etc. Mutagenic activity and acute toxicity of P. hydropiper were also reported.

Keywords: P. hydropiper, polygonaceae, traditional uses, phytochemical constituents, pharmacological aspects


How to Cite

OJAH, A., BORTHAKUR, M. K., & KALITA, J. C. (2022). AN OVERVIEW OF THE TRADITIONAL USES, PHYTOCHEMICAL CONSTITUENTS, PHARMACOLOGICAL AND TOXICOLOGICAL ASPECTS OF PERSICARIA HYDROPIPER (L.) DELARBRE. UTTAR PRADESH JOURNAL OF ZOOLOGY, 43(3), 71–85. https://doi.org/10.56557/upjoz/2022/v43i32924

Downloads

Download data is not yet available.

References

Smith-Hall C, Larsen HO, Pouliot M. "People, plants and health: a conceptual framework for assessing changes in medicinal plant consumption". Journal of Ethnobiology and Ethnomedicine. 2012; 8: 43. DOI:10.1186/1746-4269-8-43

Hamilton AC. Medicinal plants, conservation and livelihoods. Biodiversity and Conservation. 2004; 13:1477–517.

Dhar P. Autonomic responses in high altitude and adaptogenic efficacy of phytococktail from trans-Himalayan plants PhD thesis. Bharathiar University, Coimbatore, India. 2013.

The Plant List, “A working list of all plant species,” 2013. Available: http://www.theplantlist.org/.

USDA, “Polygonum hydropiper L. marshpepper knotweed,” January 2014, Available:http://www.plants.usda.gov/core/profile?symbol=POHY.

Noor Hashim NH, Abas F, Shaari K, Lajis NH. Antioxidant and xanthine oxidase inhibitory activities of Persicaria hydropiper. International Journal of Food Properties. 2013; 16(5):1028-1036.

Maw TT. Morphological, phytochemical investigation and nutritional values on leaves of Polygonum hydropiper L. 3rd Myanmar Korea Conference Research Journal. 2020; 3(3):1019-1026

Timson J. Polygonum hydropiper L. Journal of Ecology. 1966; 54(3):815-821.

Holm LG, Pancho JV, Herberger JP, Plucknett DL. A geographic atlas of world weeds. Malabar, Florida, USA: Krieger Publishing Company; 1991.

Peng ZF, Strack D, Baumert A, Subramaniam R, Goh NK, Chia TF, Tan SN and Chia LS. Antioxidant flavonoids from leaves of Polygonum hydropiper L. Phytochemistry. 2003; 62(2): 219-228.

Fukuyama Y, Sato T, Asakawa Y, Takemoto T. A potent cytotoxic warburganal and related drimane-type sesquiterpenoids from Polygonum hydropiper. Phytochemistry. 1980; 21(12):2895–2898.

Ministry of Health, Labour and Welfare, “List of existing food additives,” in Foods Food Ingred (Editorial) Japan. 1995; 166: 93-101.

Huq AKMM, Jamal JA, Stanslas J. Ethnobotanical, Phytochemical, Pharmacological, and Toxicological Aspects of Persicaria hydropiper (L.) Delarbre. PMC. US National Library of Medicine National Institutes of Health. 2014, 16.

Duke JA, Ayensu ES. Medicinal Plants of China, Reference Publications, Algonac, USA; 1985.

Chevallier A. The encyclopedia of medicinal plants. London: Dorling Kindersley; 1996:185. ISBN 9-780751- 303148.

Jan M, Mir TA, Khare RK. Indigenous medicinal usage of family Solanaceae and Polygonaceae in Uri, Baramulla, Jammu and Kashmir. Journal of Medicinal Herbs and Ethnomedicine. 2020; 6:086-089

Moerman D. Native American Ethnobotany, Timber Press, Oregaon, USA; 1998.

Xiao PG, Wang NG. Can ethnopharmacology contribute to the development of anti-fertility drugs? Journal of Ethnopharmacology. 1991; 32:167-177.

Loi TD. The Glossary of Vietnamese medicinal plants and item. Hanoi Medicine Publishing House, Hanoi, Vietnam, 2000: 283-284.

Hanif Bari S, Rahmatulla M. Medicinal plants of the Santal tribe residing in Rajshahi District, Bangladesh. American-Eurasian Journal of Sustainable Agriculture. 2009; 3(2):220-226.

Rahmatullah M, Mukti I, Haque A. An ethnobotanical survey and pharmacological evaluation of medicinal plants used by the Garo tribal community living in Netrakona Drstrict, Bangladesh. Advances in Natural and Applied Sciences. 2009; 3:402-418.

Kadir MF, Bin Sayeed MS, Mia MM. Ethnopharmacological survey of medicinal plants used by traditional healers in Bangladesh for gastrointestinal disorders. Journal of Ethnopharmacology 2013; 147(1):148-56. DOI: 10.1016/j.jep.2013.02.023.

Ghani A. Medicinal plants of Bangladesh: chemical constituents and uses. Asiatic Society of Bangladesh Dhaka, Bangladesh, 2nd edition; 1998

Hazarika A, Sarma HN. Polygonum hydropiper crude root extract mimics estrogenic properties in females: Evidence of uterine protein profiles studied by sodium dodesyl sulphate polyacrylamide gel electrophoresis. Reproductive Medicine and Biology. 2006; 5(2):155-60 DOI: 10.1007/BF03016151

Das NJ, Saikia SP, Sarkar S, Devi K. Medicinal plants of North Kamrup district of Assam used in primary healthcare system. Indian Journal of Traditional Knowledge. 2006; 5(4):489-493

Barukial J, Sarmah JN. Ethnomedicinal plants used by the people of Golaghat District, Assam, India. International Journal of Medicinal and Aromatic Plants. 2011; 1(3):203-211.

Choudhary RK, Oh S, Lee J. An ethnomedicinal inventory of knotweeds of Indian Himalaya", Journal of Medicinal Plant Research. 2011; 5(10):2095-2103

Choudhury RK, Srivastava RC. IPR and traditional knowledge of Adi, Memba and Khamba tribes of upper siang distric, Arunachal Pradesh. The National Conference on IPR: Plant Varieties and Genome Conservation. K. Arvind, Ed, S.P. Mukharjee College; 2006.

Khatun A, Imam M, Rana M. Antinociceptive effect of methanol extract of leaves of Persicaria Hydropiper in mice. BMC Complementary and Alternative Medicine 2015; 15: 63. DOI: 10.1186/s12906-015-0558-y.

Yang Y, Yu T, Jang HJ, Byeon SE, Song SY, Lee BH, Rhee MH, Kim TW, Lee J, Hong S, Cho JY. In vitro and in vivo anti-inflammatory activities of Polygonum hydropiper methanol extract. Journal of Ethnopharmacology. 2012; 139(2):616-25. DOI: 10.1016/j.jep.2011.12.003

Ayaz M, Junaid M, Ullah F, Sadiq A, Ovais M, Ahmad W, Ahmad S, Zeb A. Chemical profiling, antimicrobial and insecticidal evaluations of Polygonum hydropiper L. BMC Complementary and Alternative Medicine. 2016; 16:502. DOI: 10.1186/s12906-016-1491-4

Ayaz M, Junaid M, Ahmed J, Ullah F, Sadiq A, Ahmad S, Imran M. Phenolic contents, antioxidant and anticholinesterase potentials of crude extract, subsequent fractions and crude saponins from Polygonum hydropiper L. BMC Complementary and Alternative Medicine. 2014;14:145. DOI: 10.1186/1472-6882-14-145.

Ayaz M, Junaid M, Subhan F, Ullah F, Sadiq A, Ahmad S, Imran M, Kamal Z, Hussain S, Shah SM. Heavy metals analysis, phytochemical, phytotoxic and anthelmintic investigations of crude methanolic extract, subsequent fractions and crude saponins from Polygonum hydropiper L. BMC Complementary and Alternative Medicine. 2014;14:465. DOI: 10.1186/1472-6882-14-465.

Ayaz M, Junaid M, Ullah F, Sadiq A, Subhan F, Khan MA, Ahmad W, Ali G, Imran M, Ahmad S. Molecularly characterized solvent extracts and saponins from Polygonum hydropiper L. show high anti-angiogenic, anti-tumor, brine shrimp, and fibroblast NIH/3T3 cell line cytotoxicity. Frontiers in Pharmacology. 2016; 7:74. DOI: 10.3389/fphar.2016.00074.

Ayaz M, Junaid M, Ullah F, Sadiq A, Ovais M, Ahmad W, Ahmad S, Zeb A. Chemical profiling, antimicrobial and insecticidal evaluations of Polygonum hydropiper L. BMC Complementary and Alternative Medicine. 2016; 16:502.

Sharma R. Medicinal plants of India-an encyclopedia. Delhi-110035: Daya Publishing House. 2003:46-7.

Nakao M, Ono K, Takio S. The effect of calcium on flavanol production in cell suspension cultures of Polygonum hydropiper. Plant Cell Reports. 1999; 18(9):759-763.

Yang X, Wang BC, Zhang X, Yang SP, Li W, Tang Q, Singh GK. Simultaneous determination of nine flavonoids in Polygonum hydropiper L. samples using nanomagnetic powder three-phase hollow fibre-based liquid-phase microextraction combined with ultrahigh performance liquid chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2011; 54(2):311-6. DOI:10.1016/j.jpba.2010.08.026.

Batool A, Saleem M, Alamgeer, Mushtaq MN, Alotaibi NH, Alharbi KS, Bukhari SNA. The potential protective effect of the Polygonum hydropiper L against the development of fructose-induced oxidative stress and metabolic disorders in male Sprague-Dawely rats. The Journal of Pharmacy and Pharmacology. 2021: rgab071. DOI: 10.1093/jpp/rgab071

Sultana R, Hossain R, Adhikari A, Ali Z, Choudhary MI, Zaman MS. Hydropiperside, a new sphingoglycolipid from Polygonum hydropiper. Natural Product Communications. 2015;10(4):641-643.

Xiao H, Rao Ravu R, Tekwani BL, Li W, Liu WB, Jacob MR, Khan SI, Cai X, Peng CY, Khan IA, Li XC, Wang W. Biological evaluation of phytoconstituents from Polygonum hydropiper. Natural Product Research. 2017; 31(17):2053-2057. DOI: 10.1080/14786419.2016.1269094.

Noor Hashim NH, Abas F, Shaari K, Lajis NH. LC–DAD–ESIMS/MS characterization of antioxidant and anticholinesterase constituents present in the active fraction from Persicaria hydropiper. LWT-Food Science and Technology. 2012;46(2):468-476.

Aziman N, Abdullah N, Bujang A, Mohd Noor Z, Abdul Aziz A, Ahmad R. Phytochemicals of ethanolic extract and essential oil of Persicaria hydropiper and their potential as antibacterial agents for food packaging polylactic acid film. Journal of Food Safety. 2020; e12864. Available: https://doi.org/10.1111/jfs.12864

Ayaz M, Sadiq A, Wadood A, Junaid M, Ullah F, Zaman Khan N. Cytotoxicity and molecular docking studies on phytosterols isolated from Polygonum hydropiper L. Steroids. 2019; 141:30-35. DOI: 10.1016/j.steroids.2018.11.005.

Takabe W, Yamaguchi T, Hayashi H, Sugimura N, Yagi M, Yonei Y. Identification of antiglycative compounds in Japanese red Water Pepper (red leaf variant of the Persicaria hydropiper sprout). Molecules. 2018; 23(9):2319. DOI: 10.3390/molecules23092319.

Kiem PV, Nhiem NX, Cuong NX, Hoa TQ, Huong HT, Huong le M, Minh CV, Kim YH. New phenylpropanoid esters of sucrose from Polygonum hydropiper and their antioxidant activity. Archives of Pharmacal Research. 2008; 31(11):1477-82. DOI: 10.1007/s12272-001-2133-y.

Barnes CS, Loder JW. Structure of polygodial: a new sesquiterpene dialdehyde from Polygonum hydropiper. Australian Journal of Chemistry. 1962; 15:322-327.

Yagi A, Uemura T, Okamura N, Haraguchi H, Imoto T, Hashimoto K. Antioxidative sulphated flavonoids in leaves of Polygonum hydropiper. Phytochemistry. 1994;35(4): 885-887.

Nasir A, Khalil AAK, Bhatti MZ, Ur Rehman A, Li J, Parveen Z. Review on Pharmacological and Phytochemical Prospects of Traditional Medicinal Plant: Persicaria hydropiper (Smartweed). Current Topics in Medicinal Chemistry. 2021; 21(12):1027-1036. DOI: 10.2174/1568026621666210303145045.

Duraipandiyan V, Indwar F, Ignacimuthu S. Antimicrobial activity of confertifolin from Polygonum hydropiper. Pharmaceutical Biology. 2010; 48(2):187-190. DOI: 10.3109/13880200902902471.

Lee SH, Lee JR, Lunde CS, Kubo I. In vitro antifungal susceptibilities of Candida albicans and other fungal pathogens to polygodial, a sesquiterpene dialdehyde. Planta Medica. 1999; 65(3):204-8. DOI: 10.1055/s-1999-13981.

Kubo I, Fujita KI, Lee SH, Ha TJ. Antibacterial activity of polygodial. Phytotherapy Research. 2005; 19:1013-1017. DOI: 10.1002/ptr.

Hasan MF, Rahman M. Screening of antibacterial, antifungal and cytotoxic activities of Polygonum hydropiper L. stem extracts. International Journal of Biosciences. 2011; 1(6):47-53.

Kundu BR, Ara R, Begum MM, Sarker ZI. Effect of Bishkatali, Polygonum hydropiper L. plant extracts against the red flour beetle, Tribolium castaneum Herbst. University Journal of Zoology, Rajshahi University. 2008; 26:93-97. DOI: 10.3329/ujzru.v26i0.708

Bhattacharjee SC, Matin MM, Nasiruddin M. Insecticidal effects of two medicinal plants Polygonum hydropiper L. and Abrus precatorius L. leaves against the rice weevil Sitophilus oryzae L.(Coleoptera: Curculionidae). Journal of Biodiversity Conservation and Bioresource Management. 2019; 5(2):107-114. DOI: 10.3329/jbcbm.v5i2.44921

Song C, Zhao J, Zheng R, Hao C, Yan X. Chemical composition and bioactivities of thirteen non-host plant essential oils against Plutella xylostella L.(Lepidoptera: Plutellidae). Journal of Asia Pacific Entomology. 2022;25(2):101881.

Maheswaran R, Ignacimuthu S. Bioefficacy of essential oil from Polygonum hydropiper L. against mosquitoes, Anopheles stephensi and Culex quinquefasciatus. Ecotoxicology and Environmental Safety. 2013; 97:26-31. DOI: 10.1016/j.ecoenv.2013.06.028.

Maheswaran R, Ignacimuthu S. Effect of Polygonum hydropiper L. against dengue vector mosquito Aedes albopictus L. Parasitology Research. 2014; 113(9):3143-3150 DOI: 10.1007/s00436-014-4037-z

Rahman E, Goni SA, Rahman MT, Ahmed M. Antinociceptive activity of Polygonum hydropiper. Fitoterapia. 2002;73(7-8): 704-706. DOI: 10.1016/s0367-326x(02)00239-3.

Sharif S, Shahriar M, Haque MA, Chowdhury ZS, Islam MR, Bhuiyan MA. In-vitro antioxidant activities, anti-nociceptive and neuropharmacological activities of Polygonum hydropiper. Journal of Biology, Agriculture and Healthcare. 2013; 3(19): 61-71.

Oany AR, Siddikey AA, Hossain MU, Islam R, Emran AA. A preliminary evaluation of cytotoxicity, antihyperglycemic and antinociceptive activity of Polygonum hydropiper L. ethanolic leaf extract. Clinical Phytoscience. 2017; 2(2). DOI: 10.1186/s40816-016-0016-5

Lee SH, Kim B, Oh MJ, Yoon J, Kim HY, Lee KJ, Lee JD, Choi KY. Persicaria hydropiper (L.) spach and its flavonoid components, isoquercitrin and isorhamnetin, activate the Wnt/β-catenin pathway and inhibit adipocyte differentiation of 3T3-L1 cells. Phytotherapy Research. 2011;25(11): 1629-1635. DOI: 10.1002/ptr.3469.

Ayaz M, Junaid M, Ullah F, Sadiq A, Khan MA, Ahmad W, Shah MR, Imran M, Ahmad S. Comparative chemical profiling, cholinesterase inhibitions and anti-radicals properties of essential oils from Polygonum hydropiper L: a preliminary anti- Alzheimer's study. Lipids in health and disease. 2015; 14:141. DOI: 10.1186/s12944-015-0145-8.

Miyazaki Y. Immune effects and antiacetylcholinesterase activity of Polygonum hydropiper L. Bioscience of Microbiota, Food and Health. 2016; 35(2):69-75. DOI: 10.12938/bmfh.2015-016.

Zhang W, Pan Y, Qu S, Wang D, Cheng S, Liu X. Anti-inflammatory effects of an extract of Polygonum hydropiper stalks on 2,4,6-trinitrobenzenesulphonic acid-induced intestinal inflammation in rats by inhibiting the NF-κB pathway. Mediators of Inflammation. 2018; 2018:6029135. DOI: 10.1155/2018/6029135.

Ren S, Chen B, Ma Z, Hu H, Xie Y. Polygonum hydropiper extract attenuates ethanol-induced gastric damage through antioxidant and anti-inflammatory pathways. Brazilian Journal of Medical and Biological Research. 2021; 54(8):e10841. DOI: 10.1590/1414-431X2020e10841.

Munira S, Sultana F, Mollika S, Nesa L, Ria J, Islam MM. Anti-neoplastic activities of Polygonum hydropiper Linn. against ehrlich ascites carcinoma in swiss albino mice. Advances in Biological Research. 2013; 7(1):09-14. DOI: 10.5829/idosi.abr.2013.7.1.71160

Mahnashi MH, Alqahtani YS, Alyami BA, Alqarni AO, Ullah F, Wadood A, Sadiq A, Shareef A, Ayaz M. Cytotoxicity, anti-angiogenic, anti-tumor and molecular docking studies on phytochemicals isolated from Polygonum hydropiper L. BMC Complementary Medicine and Therapies. 2021; 21(1):239. DOI: 10.1186/s12906-021-03411-1.

Akhter R, Haque MA, Bhuiyan MA, Shahriar M. In vivo pharmacological investigation of leaf of Polygonum hydropiper (L.). Dhaka University Journal of Pharmaceutical Sciences. 2014; 12(2):165-169. DOI: 10.3329/dujps.v12i2.17619.

Shahed-Al-Mahmud M, Lina SMM. Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice. Clinical Phytoscience. 2017; 3(20):1-12. DOI: 10.1186/s40816-017-0056-5

Ayaz M, Junaid M, Ullah F, Subhan F, Sadiq A, Ali G, Ovais M, Shahid M, Ahmad A, Wadood A, El-Shazly M, Ahmad N, Ahmad S. Anti-Alzheimer's studies on β-sitosterol isolated from Polygonum hydropiper L. Frontiers in Pharmacology. 2017; 8:697. DOI: 10.3389/fphar.2017.00697.

Vohora SB, Garg SK, Chaudhury RR. Antifertility screening of plants. Part III. Effect of six indigenous plants on early pregnancy in albino rats. The Indian Journal of Medical Research. 1969; 57(5):893-9.

Garg SK, Mathur VS. Effect of chromatographic fractions of Polygonum hydropiper Linn. (roots) on fertility in female albino rats. Journal of reproduction and fertility. 1972;29(3):421-423. DOI: 10.1530/jrf.0.0290421.

Hazarika A, Sarma HN. The estrogenic effects of Polygonum hydropiper root extract induce follicular recruitment and endometrial hyperplasia in female albino rats. Contraception. 2006;74(5):426-34. DOI: 10.1016/j.contraception.2006.05.073.

Hazarika A, Sarma HN. Polygonum hydropiper crude root extract mimics estrogenic properties in females: Evidence of uterine protein profiles studied by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Reproductive Medicine and Biology. 2006; 5(2):155-160. DOI: 10.1007/BF03016151.

Goswami P, Hazarika A, Sarma H. Thin layer chromatographic fraction of root extract of Polygonum hydropiper induces vaginal epithelial cell maturation in adult ovariectomized albino rat. Journal of Endocrinology and Reproduction. 2008; 12(1):39-46

Goswami P, Hazarika A, Sarma HN. Root extract of Polygonum hydropiper alters the expression of rat uterine protein profile in the presence and absence of ovary in-situ during periimplantation period: An evidence on SDS-PAGE. Journal of Reproduction and Contraception. 2009; 20(4):223-36. DOI:10.1016/S1001-7844(10)60005-3

Goswami P, Hazarika A, Sarma H. Chromatographic Fraction of Polygonum hydropiper root modulates the expression of transforming growth factor-bI (TGF-bI) in rat uterus during days 2-6 of gestation. Journal of Reproduction and Contraception. 2011; 22(3):153-167. DOI:10.1016/S1001-7844(12)60011-X

Goswami P, Hazarika A, Sarma H. Inhibition of Insulin like growth factor-I expression by chromatographic fraction of Polygonum hydropiper root reduces implantation preference in rat. Middle East Fertility Society Journal. 2014; 19:34-41. DOI: 10.1016/

Ojah A, Borthakur MK, Kalita JC. Effect of methanolic extract of Persicaria hydropiper root on estrous cycle and reproductive hormones in female albino mice. Uttar Pradesh Journal of Zoology. 2021; 42(13):94-102.

Kuroiwa K, Shibutani M, Inoue K, Lee KY, Woo GH, Hirose M. Subchronic toxicity study of water pepper extract in F344 rats. Food and Chemical Toxicology. 2006;44(8):1236-1244. DOI: 10.1016/j.fct.2006.01.020.

Lajter I, Zupkó I, Molnár J, Jakab G, Balogh L, Vasas A, Hohmann J. Antiproliferative activity of polygonaceae species from the Carpathian Basin against human cancer cell lines. Phytotherapy Research. 2001; 27(1):77-85. https://doi.org/10.1002/ptr.4690

Morales P, Andersson M, Lewan L, Sterner O. Structure-activity relationships for unsaturated dialdehydes 6. The mutagenic activity of 11 compounds in the V79/HGPRT assay. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1992;268(2):315-321. DOI: 10.1016/0027-5107(92)90237-V

Mitchell RS, Dean JK. Polygonaceae (Buckwheat Family) of New York State. New York: New York State Museum; 1978.