Evaluation of Cytotoxic Effect in Ag/ZnO Nanocomposites on Human Myelogenous Leukaemia

S. Magara Jothi Lakshmi

St. Xavier’s College (Autonomous), affiliated to Manonmaniam Sundaranar University, Tirunelveli 627002, Tamil Nadu, India.

S. G. Rejith *

St. Xavier’s College (Autonomous), affiliated to Manonmaniam Sundaranar University, Tirunelveli 627002, Tamil Nadu, India.

*Author to whom correspondence should be addressed.


Abstract

The Ag/ZnO nanocomposite was successfully synthesized through the co-precipitation method, as confirmed by the simultaneous presence of Ag and ZnO reflections in powder X-ray diffraction analysis, validating its formation. Analysis using FESEM revealed an average particle size of around 22 nm and displayed a unique flower-like morphology, indicating a distinctive self-assembly and growth pattern of the nanocomposite. Structural composition and functional groups were studied using FT-IR spectroscopy. The nanocomposite exhibited direct and indirect band gaps of 3.06 and 3.00 eV, respectively, determined through UV-Vis NIR spectrometry and Tauc plot analysis. Evaluation of the cytotoxic effect on K562 (human myelogenous leukaemia) cells demonstrated a concentration-dependent decrease in cell viability, highlighting the potential of the nanocomposite to induce cytotoxic effects on these cancer cells.

Keywords: Ag/ZnO, nanocomposite, co-precipitation, band gap, cytotoxicity


How to Cite

Lakshmi, S. M. J., & Rejith, S. G. (2024). Evaluation of Cytotoxic Effect in Ag/ZnO Nanocomposites on Human Myelogenous Leukaemia. UTTAR PRADESH JOURNAL OF ZOOLOGY, 45(12), 102–113. https://doi.org/10.56557/upjoz/2024/v45i124109

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