PHYTOMOLECULES OF Bacopa monnieri DISPLAY POSITIVE AFFINITY FOR STEROL 14-ALPHA-DEMETHYLASE OF Trichophyton sp: POSSIBLE PREVENTIVE AND THERAPEUTIC USAGE IN TINEACAPITIS
SUNANYA DAS
Centurion University of Technology and Management, Odisha, India.
BABITA DAS
Centurion University of Technology and Management, Odisha, India.
GAGAN KUMAR PANIGRAHI
Centurion University of Technology and Management, Odisha, India.
MUKUNDJEE PANDEY
Centurion University of Technology and Management, Odisha, India.
GHANASHYAM MAHAKUR
Centurion University of Technology and Management, Odisha, India.
SIDHARTHA RAY
Centurion University of Technology and Management, Odisha, India.
SANJEEB DAS
Centurion University of Technology and Management, Odisha, India.
JOGESH KUMAR NAYAK
Centurion University of Technology and Management, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Trichophyton sp causes Tineacapitis. Strikingly, Tineacapitis occurs primarily during specific molecular events, thus acting as a potential clinical biomarker. Further, Tineacapitis may also activate further downstream events, supporting the detrimental phase. To restrict the activity of Tineacapitis, several bio molecules can be deployed, of which the phytochemicals can be the best alternative. Molecular docking-based screening of a few phytochemicals revealed that the phytochemicals effectively associate with the active site of the sterol14-alpha-demethylase of Trichophyton sp and hence bears diagnostic and therapeutic potentials against Tineacapitis.
Keywords: Phytochemical, Biovia discovery studio, Bacopa monnieri, metabolic pathways, Tineacapitis, Trichophyton