TRANSGENERATIONAL REPERCUSSION OF PATERNAL DIABETES ON BLOOD GLUOSE LEVEL OF F-1 MALE LITTERS Mus musculus AND THEIR PROBABLE RECUPERATION USING Syzigium cumuni SEED POWDER

Main Article Content

KUMARI REKHA

Abstract

Hyperglycemic condition was induced in male mice by injecting Alloxan Monohydrate which led to deficiency in insulin secretion in the mice followed by offsprings of F1 generation, obtained after mating diabetic male with normal female.

The aim of study was to investigate the ameliorative effect of Syzigium cumuni seed powder on blood glucose level of F1 male generation obtained when diabetic male mice was mated with normal female .Fixed dose of syzigium cumuni seed powder were given along with food to F1 generation and blood glucose level were observed at a regular intervals for three weeks.

Syzigium cumuni seed powder restores the histoarchitecture of pancreatic β cells and stimulates the secretion of pancreatic insulin in F1 generation of male mice. Blood glucose level were found to return to their normal levels. Significant reduction in the alterations or abnormalities (i.e. smaller and more irregular shaped islets) in F1 male mice generation were noticed.

Hyperglycemia may influence the epigenetic modifications during spermatogenesis and these epigenetic alterations in pancreatic structures cannot be normalized by providing normal diet implying that these changes were trangenerational and may be inherited through male germ line and passed onto more than one generations.

In near future, transgenerational /epigenetic factors may be regarded as important aspect in determining risk of diabetes.

Keywords:
Hyperglycemia, histoarchitecture, epigenetic, transgenerational, offsprings, spermatogenesis, Syzigium cumuni

Article Details

How to Cite
REKHA, K. (2020). TRANSGENERATIONAL REPERCUSSION OF PATERNAL DIABETES ON BLOOD GLUOSE LEVEL OF F-1 MALE LITTERS Mus musculus AND THEIR PROBABLE RECUPERATION USING Syzigium cumuni SEED POWDER. UTTAR PRADESH JOURNAL OF ZOOLOGY, 41(10), 157-161. Retrieved from https://mbimph.com/index.php/UPJOZ/article/view/1634
Section
Original Research Article

References

Meigs JB. Genotype score in addition to common risk factors for prediction of type-2 diabetes. N. Engl. J. Med. 2008;359(21):2208–2219 Kahn, S.E.; Hull, R.L. and Utzschneider,

Lemmens RHMJ. Syzigium .Gaertner In: R.H.M.J. Lemmens,I. Soerianegara & W.C. Wong (eds.),Plant Resources ofSouth East Asia(PROSEA). 1996;5:441-474. Timber tree:Minor commercial timbers. Backhuys Publishers, Leiden.

Mabberley DJ. The Plant –book.2nd ed.Cambridge University Press; 1997.

Jensen J. Gene regulatory factors in pancreatic development.Dev.Dyn. 2004;229:176-200.

J Petrik, B Reusens, E Arany, C Remacle, C, Coelho, JJ Hoet, DJ Hill. A low protein diet alters the balance of islet cell replication and apoptosis in thefetal and neonatal rat and is associated with a reduced pancreatic expression of insulin- like growth factor –II. Endocrinology. 1999;140:4861-4873.

Pinney SE, Simmons RA. Metabolic programming, epigenetics, and gestational diabetes mellitus. Curr Diab Rep.12:67–74 Zamudio, N.M.; Chong, S.; O’Bryan, M.K. (2008): Epigenetic regulation in male germ cells. Reproduction. 2012;136:131–46.

Miki K, Qu W, Goulding EH, Willis WD, Bunch DO. Glyceraldehyde 3- phosphate dehydrogenase-S, a sperm specific glycolytic enzyme, is required for sperm motility and male fertility. Proc Natl Acad USA. 2004;101: 16501-6.

Ramya S, Neethiranjan K, Jayakumararaj R. Profile of bioactive compounds in Syzigium cumini- a review. J. Pharm. Res. 2012;5:4548-4553.

Sharma B, Balomajumder C, Roy P. Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food Chem Toxicol. 2008;46:2376 83.

Ahmed F, Chandra J, Timmaiah NV. An in vitro study on the inhibitory activities of Eugenia jambolana seeds against carbohydrate hydrolyzing enzymes. J Young Pharm. 2009;1:317 21.