MORPHO METRICAL ASSESSMENT OF PANCREAS SHOWING PATERNAL DIABETES HERITABLE TO FIRST GENERATION MALE LITTERS AND THERAPEUTIC IMPACT OF BLACK PLUM (Syzigium cumuni)

Main Article Content

KUMARI REKHA

Abstract

Present study focused on morpho metrical assessment of Pancreatic parameter (pancreatic mass and pancreatic diameter) of first generation male litters obtained from diabetic male mated with normal female and therapeutic impact of black plum. Alloxan persuade diabetic male mice leads to decrease in sufficient insulin dissimulation in them. Fixed dose of Black plum (Syzigium cumuni) seed powder were fed along with food to First generation and morphometry of pancreas was done. Black plum (Syzigium cumuni) seed powder reinstate the histoarchitecture of pancreatic β cells and accelerate the secretion of pancreatic insulin in First generation male mice. Blood glucose levels were observed to recur to their normal levels. Significant reduction in the alterations or abnormalities (i.e. smaller and more irregular shaped islets) in First generation male mice were noticed. Hyperglycemia may affect the epigenetic modifications during spermatogenesis and these epigenetic alterations in pancreatic structures cannot be normalized by giving normal diet implying that these alterations were transgenerational and may inherited through male germ line and move onto more than one generations. In near future, transgenerational or epigenetic factors may be regarded as huge aspect in assessing risk of diabetes.

Keywords:
Epigenetic, histoarchitecture, hyperglycemia, inherited, spermatogenesis, Syzigium cumuni, transgenerational, offsprings.

Article Details

How to Cite
REKHA, K. (2020). MORPHO METRICAL ASSESSMENT OF PANCREAS SHOWING PATERNAL DIABETES HERITABLE TO FIRST GENERATION MALE LITTERS AND THERAPEUTIC IMPACT OF BLACK PLUM (Syzigium cumuni). UTTAR PRADESH JOURNAL OF ZOOLOGY, 41(15), 22-27. Retrieved from https://mbimph.com/index.php/UPJOZ/article/view/1683
Section
Original Research Article

References

Almeida C, Cruz R. Diabetes mellitus II an epidemic of the 21st century: Therapeutic challenges. European Journal of Public Health; 2019. Available:https://doi.org/10.1093/eurpub/ckz035.006

Patel S. Anti-obesity and anti-diabetes foods high fiber diets. Encyclopedia of Food Chemistry; 2019. Available:https://doi.org/10.1016/b978-0-08-100596-5.21734-4

Anoosha V, Saini S, Kaushik HD. Annals of Plant Protection Sciences; 2018. Available:https://doi.org/10.2337/diab.32.5.408

Webiel ER. Morphometry of human lungs. Materials and Methods of Preparation for Morphometric studies of lungs; 1963. Available:https://doi.org/10.1016/b978-1-4832-0076-7.50009-0

Porter G, Festing M. Laboratory animals. Effects of daily handling and other factors on weight gain of mice from birth to six weeks of age; 1969. Available:https://doi.org/10.1258/002367769781071862

Lenzen S. The mechanisms of alloxan-and streptozotocin-induced diabetes. Diabetologia. 2008;51:216-226. Available:https://doi.org/10.1007/s00125-007-0886-7

Yashimoto S, Kurahashi M, Masui H, Sakamoto K. Effect of diethyldithiocarbamate on diabetogenic action of alloxan in rats. Diabetes Research and Clinical Practices; 1993. Available:https://doi.org/10.1016/0168- 8227(93)90143-s

Harrowfield JM, Skelton BW, Soudi AA, White AH. Crystal structure of alloxan monohydrate: A redetermination. Australian Journal of Chemistry; 1989. Available:https://doi.org/10.1071/ch9891795

Hoftiezer V, Carpenter AM. Comparision of sreptozotocin and alloxan – induced diabetes in rat, including volumetric quantitation of pancreatic islets. Diabetologia. 1973;9:178-184. Available:https://doi.org/10.1007/bf01219780

Adeela SL, Khalid S, Sadia A, Muhammad. Maleoffsprings of both diabetic parents have high insulin resistance and serum leptin level compared to those with one diabetic parent. HORMONES; 2008. Available:https://doi.org/10.14310/horm.2002.1212

Waterland RA, Jirtle RL. Transposable elements: Targets for early nutritional effects on epigenetic gene regulation. Mol. Cell. 2003; 5293-5300. Available:https://doi.org/10.1128/mcb.23.15.5293-5300.2003

Jensen J. Gene regulatory factors in pancreatic development. Dev. Dyn. 2004;229:176-200. Available:https://doi.org/10.1002/dvdy.10460

Erlandsen SL, Hegre OD, Parsons JA, McEvoy RC, Elde RP. Pancreatic islet cell hormones distribution of cell types in the isletand evidence for the presence of somatostatin and gastrin within the D cell. Journal of Histochemistry & Cytochemistry; 1976. Available:https://doi.org/10.1177/24.7.60437

Pinney SE, Simmons RA. Metabolic programming, epigenetics, and gestational diabetes mellitus. Curr Diab Rep. 2012;12:67–74. Available:https://doi.org/10.1007/s11892-011-0248-1

Sharma B, Viswanath G, Salunke R, Roy P. Effects of flavonoid rich extract from seeds of Eugenia jambolana (L.) on carbohydrate and lipid metabolism in diabetic mice. Food Chemistry. 2011;110:697-705. Available:https://doi.org/10.1016/j.foodchem.2008.02.068

Sharma B, Balomajumder C, Roy P. Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food and Chemical Toxicology 2008;46(7): 2376–2383. Available:https://doi.org/10.1016/j.fct.2008.03.020

Ramya S, Neethiranjan K, Jayakumararaj R. Profile of bioactive compounds in Syzigium cumini- a review. J. Pharm. Res. 2012;5:4548-4553. Available:https://doi.org/10.1258/002367769781071862