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Heterocyclic bearing nitrogen constitutes the core structure of number of pharmacological and biologically active interesting compounds. Heterocyclic compounds show vital role in the field of pharmaceuticals. In the present investigation treatment of diseases possess challenging problems due to emerging infectious disease and also due to increased multi drug resistance pathogens in spite of commercially available antibiotics and drugs search for novel compound with theoretical values are mandatory Pyrazole was screened for anti-bacterial activity against shigella flexneri, E. coli, Pseudomonas aeruginosa, Pseudomonas fluorescence respectively. The anti-fungal activity of three fungal namely as Aspergillus niger, Aspergillus flavus and Odium caricae were evaluated and it was found to be pyrazole was found to be effectively. The anti-inflammatory performance of pyrazole compound was tested with formalin induced paw edema test activity by oral administration at a dose level of 100mg/kg compared to reference drug paracetamol. The potential analgesic activity of pyrazole using animal model was carried out with oral administration of pyrazole 100mg/kg of body weight. The anti-pyretic activity of pyrazole was determined on yeast induced pyrexia in albino mice. FTIR is an important tool analyzed to analysis functional group modification of pyrazole and its derivatives. In my research findings, strongly recommended for pyrazole as best drug to the enzyme and greater the number of sites occupied, the more effective the drug is likely to be in inhibiting the action of the enzymes.
Rosenbrock H, Giovannini R, Schanzle G, Koros E, Runge F, Fuchs H, Marti A, Reymann KG, Schroder UH, Fedele E, et al. The novel phosphodiesterase 9A inhibitor BI 409306 increases cyclic guanosine monophosphate levels in the brain, promotes synaptic plasticity, and enhances memory function in rodents. J. Pharmacol. Exp. Ther. 2019;371:633–641.
Le Pichon CE, Meilandt WJ, Dominguez S, Solanoy H, Lin H, Ngu H, Gogineni A, Sengupta Ghosh A, Jiang Z, Lee SH, et al. Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Sci. Transl. Med. 2017;9:eaag0394.
Surendra kumar R, Ibrahim A, Arif Anish A, Akbar I. Anti-inflammatory and anti-microbial activities of novel pyrazole analogues. Saudi Journal of Biological Science. 2015;1:150 -157.
Levai A, Silva AMS, Cavaleiro JA, Alkorta I, Elguero J, Vejeko J. Synthesis of pyrazole by treatment of 3-Benzylchromones, 3-Benzylflavones and their 4- Thio analogues with hydrazine. Eur. J. Org. Chem. 2007;12: 2825-2832.
FarukAlam S, Biplob KR, Dey Rejaulkorim Z, Arpitachakrabarty A. Synthesis, characterization, or biological evaluation of pyrazole derivation. Journal of Global Trents in pharmaceutical Science. 2015;6(1):2411-2416.
Liu XH, Cui P, Song BA, Bhadury PS, Zhu HL, Wang SF. Synthesis structure and antibacterial activity of novel 1-(5-substituted-4,5-dihydropyrazole-1-yl) etanoneoxime ester derivatives. Bioorgan. Med. Chem. 2008; 16:4075-4082.
Sangapure S.S, Bodke Y, Raga B. Synthesis of some new pyrazolines as potential antimicrobial agents. Ind. J. Heterocycl. Chem. 2001;11:31-37.
Dai H, Li Y.Q, Qin X, Zang X, Yu H.B, Fang J.X. Synthesis and biological activities of novel pyrazoleoxime derivatives containing a3-chloro-5-thiazolyl moiety. J of Food. Chem. 2008;56:10805-10810.
Makhsumov AD, Dzhurac Klichov G, Nikbae AT. Anti-inflammatory activity of some pyrazole derivatives. Pharm. Chem J. 1986;20: 289-291.
Chetan BP, Mulwar VV. Synthesis and evaluation of certain pyrazolines and relatedted compounds for their antitubercular, antibacterial and antifungal activities. Ind. J. Chem. 2000;448:232-237.
Asok K, Archana N, Sharma S. Synthesis of potentials quinazolinyl pyrazolines as anticonvulsant agents. Int. J. Hetero. Chem. 2001;9:197-201.
Due R, Shrivastava S, Sonwane S, Sonwane S.K, Srivastava SK. Pharmaological significance of synthetic heterocycles scaffold. J of Advanced in Biological Research. 2011;5(3):120-144.
Afaf kamal EL-Din EL-Ansory, Azza Teher taker, Ahmad EL-Hamad EL-Ruhmany, Sally El Awdan. Synthesis anti-inflammatory, analgesic and antipyretic activities of novel pyrazole and related fused ring derivatives. Journal of American Science. 2014;10:112-121.
Winter CA, Risley EA, Nuss GN. Carrageen in-induced edema in hind paws of the rat as an assay for anti-inflammatory drugs. J of Proc. Soc. Exp. Biol Med. 1962;111:544-549.
Roszkowski A, Rooksii WH, Tomolonis A, Miller LM. Anti-inflammatory and analgesic properties of d-2-(6’-methoxy-2’-napthyl)- propionic acid (naproxen). J. Pharmacol and Exp. Ther. 1971;179(1):114-121.
Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1996;39(5):493-496.
Vargas LYM, Castelli MV, Kouznet Sov VV, Urbina JM, Lopez SN, Sortino M. Antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers. J of Bio. Org. Med Chem. 1998;11:1531-1550.
Razi Ahmad, Mohammad Asad, Zeba Siddiqui, Anil Kumar. Screening of synthetic new heterocyclic derivatives of 3- formyl-4- hrdroxycoumarin for anti-inflammatory activity. J.P.R.H.C. 2009;1:46-62.
Mahesh S, Paschapur Swathi P, Sachin R, Ravi kumar M. Evaluation of the analgesic and antipyretic activities of ethanolic extract of male flowers (inflorescences) of borassusflabellifer l. (Arecaceae). Inter. Jour. of Phar. Pharmaceu Scie. 2009;1:20- 30.
Chawla R, Sahoo U, Arora A, Sharma PC, Radhakrishnan V. Microwave Assisted Synthesis of Some Novel 2-Pyrazoline Derivatives As Possible Antimicrobial Agents. J of Acta Poloniae Pharmaceutica - Drug Research. 2010;67(1):55-61.
Santhi N, Emayavaramban M, Gopic C, Manivannan C, Raguraman A. Free synthesis and anti-bacterial evaluation of some 2- pyrazoline derivatives. International. Journal of Advanced Chemistry. 2014;2(3): 53-58.
Sahu SK, Banejee M, Samantray A, Behera C, Azam AM.Synthesis analgesic anti-inflammatory and antimicrobial activities of some novel pyrazoline derivatives. Tro. J. of Pharm. Res. 2008;7(2): 961-969.
Dandia A, Singh R, Merienne C, Morgant G, Loupy A. Efficient microwave enhanced regioselective synthesis of a series of benimidazolyl spiro[indole-thiazolidinones] as potent anti-fungal agents and crystal structure of spiro[3H-indole-3,20-thiazolidine]-30(1,2,4-triazol-3-yl)-2,40(1H)-dione. J of Bioorg and Med. Chem. 2006;14:2409-2417.
Fang B, Zhou CH, Rao XC. Synthesis and biological activities of novel amine- derived bis-azoles as potential anti-bacterial and anti- fungal agents. Eur. J. Med. Chem. 2010; 45:4388-4398.
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