STUDY OF THE PREVENTIVE EFFECT OF ROYAL JELLY AGAINST THE HEPATOTOXICITY OF TWO ANTI-TUBERCULOSIS DRUGS

RANDA DJEMIL

Biotechnology, Water, Environment and Health Laboratory, Faculty of Life and Natural Sciences, Abbes Laghrour Khenchela University, 40000, Algeria and Faculty of Natural and Life Sciences, Abbes Laghrour University of Khenchela, Algeria.

SAMIR DJEMLI *

Applied Neuroendocrinology Laboratory, Department of Biology, Faculty of Sciences, Badji Mokhtar Annaba University Algeria.

FOUZIA DEROUICHE

Biotechnology, Water, Environment and Health Laboratory, Faculty of Life and Natural Sciences, Abbes Laghrour Khenchela University, 40000, Algeria and Faculty of Natural and Life Sciences, Abbes Laghrour University of Khenchela, Algeria.

HICHEM MAAMAR

Biotechnology, Water, Environment and Health Laboratory, Faculty of Life and Natural Sciences, Abbes Laghrour Khenchela University, 40000, Algeria and Faculty of Natural and Life Sciences, Abbes Laghrour University of Khenchela, Algeria.

SAMIA ATI

Laboratory of Animal Ecophysiology, Department of Biology, Faculty of Sciences, Badji Mokthar University, Annaba, Algeria.

DALEL ARROUF

Faculty of Natural and Life Sciences, Abbes Laghrour University of Khenchela, Algeria.

AHLAM HOUGGAS

Faculty of Natural and Life Sciences, Abbes Laghrour University of Khenchela, Algeria.

KAMEL KHELLILI

Laboratory of Animal Ecophysiology, Department of Biology, Faculty of Sciences, Badji Mokthar University, Annaba, Algeria.

*Author to whom correspondence should be addressed.


Abstract

Aim: Hepatotoxicity is a well-known adverse effect during treatment with antituberculosis drugs, in particular the combination of rifampicin (RMP) and isoniazid (INH).

Objective: The primary purpose of this study was to assess the contributory role of royal jelly decrease to in antituberculosis drug hepatotoxicity.

Materials and Methods: This study is an experimental study in which the preventive effect of Royal jelly on isoniazid (INH), and rifampicin (RMP) hepatotoxicity is evaluated. In this study 21 male rabbit were randomly placed in three members groups including: control group, isoniazid and rifampicin and (isoniazid (INH), and rifampicin(RMP)) /royal jelly group. At the end of the study the laboratory criteria and histological features of liver toxicity were compared in different mentioned groups.

Results: The treatment with isoniazid/ rifampicin led to Significant increase serum levels of liver enzymes, alkaline phosphate, alat and asat; and significant higher levels of albumin total proteins and Bilirubine, in compare to mixed isoniazid/ rifampicin / royal jelly also Group and the control.

Whereas, the level of GSH concentration and enzymatic antioxidants SGSH-Px were decreased in the groups treatment by Isoniasid(INH), / rifampicin(RMP)comparative to the control grop but the MDA concentration is increased in this groups compared to addition of royal jelly are not present any significant change

In addition, histological studies had not showed liver injury in isoniazid/rifampicin/ royal jelly group, while there was liver injury in isoniazid/ rifampicin alone group.

Conclusion: The royal jelly, prevent the destructive effects of on the liver; probably because of its antioxidant properties.

Keywords: Isoniazid / rifampicin, royal jelly, livermarker, rabbit


How to Cite

DJEMIL, R., DJEMLI, S., DEROUICHE, F., MAAMAR, H., ATI, S., ARROUF, D., HOUGGAS, A., & KHELLILI, K. (2022). STUDY OF THE PREVENTIVE EFFECT OF ROYAL JELLY AGAINST THE HEPATOTOXICITY OF TWO ANTI-TUBERCULOSIS DRUGS. UTTAR PRADESH JOURNAL OF ZOOLOGY, 43(2), 56–64. https://doi.org/10.56557/upjoz/2022/v43i22902

Downloads

Download data is not yet available.

References

Steele MA, Burk RF, Des Prez RM. Toxic hepatitis with isoniazid and rifampin: A meta-analysis. Chest 1991;99:46.547 1.

Laval Q. Antibiotique rifadin. Capsules de rifampine. USP dosées à 150 mg et à 300 mg ; monographie de produit: 206328 ; 2017.

World Health Organization. Side-effects of anti-tuberculosis drugs. TB/HIV: A Clinical Manual. Second Edition. Geneva. 2003;129-35.

Blumberg HM, Burman WJ, Chaisson RE. American thoracic society/centers for disease control and prevention/infectious discases society of America treatment of tuberculosis. Am J Respir Crit Care Med. 2003 ;167:603-662.

Kenney M T, Strathes B. Metabolism and pharmacokinetics of the antibiotic rifampin. Drug MetabRev. 1981;12:150-218.

Acocella G. Clinical pharmacokinetics of rifampicin. Clin.Pharmacokinet. 1978;3:108-27.

Douglas JG, McLeod M. Pharmacokinetics factors in the modern drug treatment of tuberculosis. Clin Pharmacokinet. 1999;37:127-46

De Vierse SA, Robbrecht DL, Vanholder RC, Vogelaers DP, Lameire NH. Rifampicin associated acute renal failure: pathophysiologic, 260 K. immunologic, and clinical features. Am J Kidneys Dis. 1998; 31(1):108– 15.

Castelo-Branco, Frederico Silva, de Lima, EvanoelCrizanto, Domingos, Jorge Luiz de Oliveira, Pinto, Angelo C, Lourenço, Maria Cristina S, Gomes, Karen Machad, Costa-Lima, Mariana Marques, et al. New hydrazides derivatives of isoniazid against Mycobacterium tuberculosis: Higher potency and lower hepatocytotoxicity. European Journal of Medicinal Chemistry. 2018;146:529–540. DOI: 10.1016/j.ejmech.2018.01.071

Elshama S, Abdalla ME, Mohamed AM role of natural antioxidants in treatment of toxicity. J Toxicol Anal. 2018;1(1):3.

Silici S, Ekmekcioglu O, Eraslan G, Demirtas A. Antioxidative effect of royal jelly in cisplatin-induced testes damage, Urology. 2009;74(3):545–551.

Nakajima Y, Tsuruma K, Shimazawa M, Mishima S, Hara H. Comparison of bee products based on assays of antioxidant capacities, BMC Complement. Altern. Med. 2009;9:4.

Cavusoglu K, Yapar K, Yalcin E. Royal jelly (honey bee) is a potential antioxidant against cadmium-induced genotoxicity and oxidative stress in albino mice, J. Med. Food. 2009; 12(6):1286–1292.

Okamoto I, Taniguchi Y, Kunikata T, Kohno K, Iwaki K, Ikeda M, Kurimoto M. Major royal jelly protein 3 modulates immune responses in vitro and in vivo, Life Sci. 2003;73(16):2029–2045.

Kanbur M, Eraslan G, Beyaz L, Silici S, Liman BC, Altinordulu S, Atasever A. The effects of royal jelly on liver damage induced by paracetamol in mice, Exp. Toxicol. Pathol. 2009;61(2)123–132.

Kamakura M, Moriyama T, Sakaki T. Changes in hepatic gene expression associated with the hypocholesterolaemic activity of royal jelly, J. Pharm. Pharmacol. 2006;58(12):1683– 1689.

Jollow DL, Mitchell JR, Zampaglione Z, Gillette JR. Bromobenzene induced liver necrosis. Protective role of glutathione and evidence for 3,4–bromobenzene oxide as the hepatotoxic metabolite. Pharmacol. 1974; 11:151-69.

Bradford M. A rapid and sensitive method for the quantities of microgram quantities of protein utilizing the principle of protein-binding. Anal Biochem. 1976;72:248-54.

Gabe G. Techniques histologques et histochimique .Masson-C,Paris. 1968; 1113.

Henry M Blumberg, William J Burman, Richard E Chaisson, Charles L Daley, Sue C Etkind, Lloyd N Friedman, Paula Fujiwara, Malgosia Grzemska, Philip C Hopewell, Michael D Iseman, Robert M Jasmer, Venkatarama Koppaka, et al. american thoracic society, center s for disease control and prevention and the infectious diseases society. Am J Respir Crit Care Med. 2003;167(4):603-62. DOI: 10.1164/rccm.167.4.603

Yee D, Valiquette C, Pelletier M, et al. Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis. Am J Respir Crit Care Med. 2003;167:1472—7.

Silici S, Ekmekcioglu O, Eraslan G, Demirtas A. Antioxidative effect of royal jelly in cisplatin-induced testes damage. Urology. 2009;74:545–551

Rubaltelli FF, Gourley GR, Loskamp N, et al. Transcutaneous bilirubin measurement: A multicenter evaluation of a new device. Pediatrics. 2001;107:1264-71. ;

Aouam K, Chaabane A, Loussaief C, et al. Les effets indésirables des antituberculeux : Epidémiologie, mécanismes et conduite à tenir. Med Mal Inf. 2007;37:253—61.

Sharma SK. Antituberculosis drugs and hepatotoxicity. Infect Genet Evol. 2004;4:167–70.

Altam C, Biour M, Grange JD. Toxicité hépatique des antituberculeux : rôle des différents médicaments : 199 observations. Presse Med. 1993;22(26):1212.

Fromm M F, Busse D, Kroemer H K &Eichelbaum M. Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin. Hepatology. 1997;24:796–80.

Douglas JG, McLeod M. Pharmacokinetics factors in the modern drug treatment of tuberculosis.ClinPharmacokinet. 1999;37:127-46.

Hamada Y, Ford N, Schenkel K, Getahun H. Three-month weekly rifapentine plus isoniazid for tuberculosis preventive treatment: a systematic review int j tuberc lung dis. 2018;22(12):1422–1428.

Suvichapanich S, Wattanapokayakit S, Mushiroda T, et al. Genomewide association study confirming the association of NAT2 with susceptibility to antituberculosis drug-induced liver injury in Thai patients, Antimicrob. Agents Chemother. 2019;63(8). [published Online First: Epub Date].

Hajimehdipoor H, Sadeghi Z, Elmi S, Elmi A, Ghazi-Khansari M, AmanzadehY. Protective effects of Swertialongifolia Boiss. anditsactivecompound, swerchirin, on paracetamolinducedhepatotoxicity in mice. JP harm Pharmacol. 2006;58:277–8.

Karadeniz A, Simsek N, Karakus E, Yildirim S, Kara A, Ismail, Fikrullah K, Habib E, Mehmet T. Royal Jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treatedwith cisplatin. HindawiPublishing Corporation OxidativeMedicine and Cellular Longevity; 2011.

Apimondia - standing commission of apitherapy. Traité d’Apithérapie. La médecine par les abeilles [cédérom] v.1.01 PC-Mac Produit par Api-Ar International SA Ŕ Brussels ; 2001. ISBN : 2- 9600270-0-0. 2001.

Radhika S, Ramneek K, Manishi M, Vija L. Assessment of hepatotoxicity of first-line anti-tuberculosis drugs on Wistar rats . Naunyn-Schmiedeberg's Arch Pharmacol : 27; 2017.

Kargar Jahromi H, Pourahmad M, Kargar Jahromi A.Protective effects of salep against isoniazid liver toxicity in wistar rats. Journal of Traditional and Complementary Medicine, Elsevier; 2017.

Ali Karadeniz, NejdetSimsek, Emre Karakus, Serap Yildirim, Adem Kara, Ismail Can, FikrullahKisa, Habib Emre,5and Mehmet Turkeli. Royal Jelly Modulates Oxidative Stress and Apoptosis inLiver and Kidneys of Rats Treated withCisplatin. Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity; 2011. ID 981793. Available:10p.sdoi:10.1155/2011/981793

Rasha E Mostafa a, Salma A El-Marasy a, Gehad A Abdel Jaleel a, Rofanda M Bakeer. Protective effect of royal jelly against diclofenac-induced hepato-renal damage and gastrointestinal ulcerations in rats Heliyon. 2020;6:e03330.