Published: 2022-06-04

DOI: 10.56557/upjoz/2022/v43i103037

Page: 45-51


Department of Zoology, S. V. College, Aligarh, 202001, Uttar Pradesh, India.


Department of Zoology, D. S. College, Aligarh, 202001, Uttar Pradesh, India.

*Author to whom correspondence should be addressed.


Bisphenol-A is a highly controversial industrial chemical. Its large-scale production and subsequent release into the environment far exceed the ability of natural processes to degrade it. This has made Bisphenol-A ubiquitous in all environmental matrices – land, air and water. The presence of Bisphenol-A in inland water bodies raises serious concerns about its effects on aquatic fauna and on human beings. Bisphenol-A exposure is known to induce oxidative stress resulting in tissue damage in various fish species. Increase in tissue damage due to Bisphenol-A exposure is reported to result in an elevation of serum urea and creatinine. Co-exposure to antioxidants can reduce the damage due to Bisphenol-A exposure. The objective of this study was to investigate if exposure to Bisphenol-A resulted in elevated serum urea and creatinine in Channa punctatus and if co-exposure of the fish to vitamin C could ameliorate these changes. The results show that exposing Channa punctatus to Bisphenol-A for 15 days resulted in a significant increase in serum urea and creatinine after Bisphenol-A exposure. Co-exposure to vitamin C resulted in an amelioration of the increase in serum urea and creatinine. However, in groups exposed to higher concentrations of Bisphenol-A for 15 days, co-exposure to vitamin C could not completely reverse the changes in serum urea and creatinine.

Keywords: Bisphenol-A, BPA, Channa punctatus, serum urea, creatinine, vitamin C

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