An Overview of Lewis Blood Group

PDF

Published: 2023-08-07

DOI: 10.56557/upjoz/2023/v44i173589

Page: 27-32


Malojirao Bhosale

Department of Forensic Biology, Institute of Forensic Science, 15, Madame Cama Rd., Mumbai-400032, Maharashtra, India.

A. D. Harkal *

New Arts, Commerce and Science College, Ahmednagar, India.

S. A. Kawade

R. B. Narayanrao Borawake College, Shrirampur, District Ahmednagar - 413 709, Maharashtra, India.

Neha Vishe

Department of Forensic Biology, Institute of Forensic Science, 15, Madame Cama Rd., Mumbai-400032, Maharashtra, India.

Rohitha Davuluri

Department of Forensic Biology, Institute of Forensic Science, 15, Madame Cama Rd., Mumbai-400032, Maharashtra, India.

Devyani Parkhe

Department of Forensic Biology, Institute of Forensic Science, 15, Madame Cama Rd., Mumbai-400032, Maharashtra, India.

*Author to whom correspondence should be addressed.


Abstract

This review summarises the history of the Lewis blood group, the inheritance and biochemistry of Lewis antigens and antibodies, and their clinical significance. Lewis antigens are found on RBCs, other tissues like the pancreas, stomach, intestine, etc., and bodily fluids like saliva. Two independent genes, FUT2 and FUT3, synthesise fucosyltransferases, which determine Lewis blood group genotypes. There are six genotypes (Lea, Leb, Leab, LebH, Aleb, BLeb) and four phenotypes [Le (a+b+), Le (a+b-), Le (a-b+), Le (a-b-)]. Two red-cell Lewis blood groups are Lewis negative and Lewis positive. As Lewis antigens are soluble and can be neutralised by recipient antibodies, Lewis antibodies are deemed insignificant. Clinically, Lewis antigens are associated with coronary heart disease, ischemic heart disease, rotavirus, Helicobacter pylori infection, etc.

Keywords: Lewis blood group, Lewis antigens, Lewis antibodies, FUT2, FUT3, coronary heart disease and Ischemic heart disease


How to Cite

Bhosale , M., Harkal, A. D., Kawade , S. A., Vishe , N., Davuluri , R., & Parkhe , D. (2023). An Overview of Lewis Blood Group. UTTAR PRADESH JOURNAL OF ZOOLOGY, 44(17), 27–32. https://doi.org/10.56557/upjoz/2023/v44i173589

Downloads

Download data is not yet available.

References

Shaz BH. Lewis, I and P Blood Group Systems. Transfusion Medicine and Hemostasis. 2009;139–144.

Brendemoen OJ. Some factors influencing Rh immunization during pregnancy. Acta Path Microbiol Scand. 1952;31:579–583.

Hammar L, Mansson S, Rohr T, et al. Lewis phenotype of erythrocytes and Leb -active glycolipid in serum of pregnant women. Vox Sang. 1981;40:27–33.

Hanfland P, Graham HA. Immunochemistry of the Lewis-blood-group systems: partial characterization of Lea-, Leb-, and H-Type 1 (LedH)-blood-group active glycosphingolipids from human plasma. Arch Biochem Biophys. 1981;210:383–395.

Sneath JS, Sneath PHA. Transformation of the Lewis groups of human red cells. Nature. 1955;176:172.

Ramsey G, Fryer JP, Teruya J, Sherman LA.. Lewis (a-b-) red cell phenotype in patients undergoing evaluation for small intestinal transplantation. (abstract) Transfusion. 2000;40(Suppl):114S.

Marcus DM, Cass LE. Glycosphingolipids with Lewis blood group activity: uptake by human erythrocytes. Science. 1969;164:553–555.

Watkins WM. Blood-group substances. Science. 1966;152:172–181.

Mollison PL, Polley MJ, Crome P. Temporary suppression of Lewis blood-group antibodies to permit incompatible transfusion. Lancet. 1963;1:909–912.

Mourant AE. A ‘new’ human blood group antigen of frequent occurrence. Nature. 1946;158:237-238.

Andresen PH. The blood group system L: a new blood group L2. A case of epistasy within the blood groups. Acta Path Microbiol Scand. 1948;25:728–31.

Brendemoen OJ. Further studies of agglutination and inhibition in the Lea -Leb system. J Lab Clin Med. 1950;36:335–341.

Sanger R, Race RR. The Lutheran-secretor linkage in man: support for Mohr’s findings. Heredity. 1958;12:513– 520.

Grubb R. Some aspects of the complexity of the blood groups ABO. Rev Hematol. 1950;5:268–275.

Combs MR. Lewis blood group system review. Immunohaematology. 2009;25: 112-118.

Misevic G. Lewis (Le) blood group system phenotypes and genotypes. Blood and Genomics. 2019;3(1):1–8.

Reguigne-Arnould I, Couillin P, Mollicone R, et al. Relative positions of two clusters of human α-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6- FUT3-FUT5) within the microsatellite genetic map of chromosome 19. Cytogenet Cell Gen. 1995;71:158–162.

Soejima M, Koda Y. Molecular mechanisms of Lewis antigen expression. Leg Med (Tokyo). 2005;7:266–269.

Enevold C, Nielsen CH, Molbo D. et al. Lewis and AB0 blood group phenotypes in periodontitis, cardiovascular disease, obesity and stroke. Sci Rep. 2019;9:6283.

Lawler SD, Marshall R. Lewis and Secretor characters in infancy. Vox Sang. 1961;6:541–544.

Henry SM, Benny AG, Woodfield DG. Investigation of Lewis phenotypes in Polynesians: evidence of a weak secretor phenotype. Vox Sang. 1990;58: 61–66.

Issitt PD, Anstee DJ. Applied blood group serology. 4th ed. Durham, NC: Montgomery Scientific Publications; 1998.

Clausen H, Levery SB, McKibbon JM, Hakomori S. Blood group A determinants with mono- and di fucosyl type 1 chain in human erythrocyte membranes. Biochemistry. 1985;24:3578–3586.

Breimer ME, Karlsson KA, Samuelsson BE. Characterization of a human intestinal di fucosyl hepta glycosylceramide with a blood group B determinant and a type 1 carbohydrate chain. J Biol Chem. 1982;257:1079–1085.

Schenkel-Brunner H. Human blood groups: chemical and biochemical basis of antigen specificity. 2nd ed. New York: Springer-Verlag; 2000.

Hossaini AA. Neutralization of Lewis antibodies In-vivo and transfusion of Lewis incompatible blood. Am J Clin Pathol. 1972;57:489–493.

Spitalnik S, Cowles J, Cox MT, Blumberg N. Detection of IgG anti-Lewis-a antibodies in cord sera by kinetic ELISA. Vox Sang. 1985;48:235–238.

Jesse JK, Sheek KJ. Anti-Leb implicated in acute haemolytic transfusion reaction: a rare occurrence. (abstract) Transfusion. 2000;40(Suppl):115S.

Höglund P, Rosengren-Lindquist R, Wikman AT. A severe haemolytic transfusion reaction caused by anti-Lea active at 37°C. Blood Transfusion. 2013;11(3):456–459.

Delk AA, Gammon RR, Alvarez H, Benitez N, Bright F. A Hemolytic Transfusion Reaction Caused by an Unexpected Leb Antibody. Laboratory Medicine. 2021; 52(3):303–306.

Ellison RC, Zhang Y, Myers RH, Swanson JL, Higgins M, Eckfeldt J. Lewis blood group phenotype as an independent risk factor for coronary heart disease (the NHLBI Family Heart Study). Am J Cardiol. 1999;83(3):345-348.

Hein HO, Sørensen H, Suadicani P, et al . The Lewis blood group—a new genetic marker of ischaemic heart disease. Journal of Internal Medicine. 1992; 232(6):481-487.

Dentali F, Sironi AP, Ageno W, Crestani S, Franchini M. ABO blood group and vascular disease: an update. In Seminars in thrombosis and hemostasis. Thieme Medical Publishers. 2013;049- 059.

Petit JM, Morvan Y, Mansuy-Collignon S. et al. Hypertriglyceridaemia and Lewis (A-B-) phenotype in non-insulin-dependent diabetic patients. Diabetes Metab. 1997;23(3):202-204.

Green D, Jarrett O, Ruth KJ, Folsom AR, Liu K. Relationship among Lewis phenotype, clotting factors, and other cardiovascular risk factors in young adults. The Journal of Laboratory and Clinical Medicine. 1995;125(3):334-339.

Hein HO, Suadicani P, Gyntelberg F. The Lewis blood group—a new genetic marker of obesity. International Journal of Obesity. 2005;29(5):540-542.

Nordgren J, Sharma S, Bucardo F et al. Both Lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype–dependent manner. Clinical Infectious Diseases. 2014;59(11): 1567-1573.

Hutson AM, Atmar RL, Marcus DM, Estes MK. Norwalk virus-like particle hemagglutination by binding to H histo-blood group antigens. J Virol. 2003; 77:405–415.

Hilton E, Chandrasekaran V, Rindos P et al. Association of recurrent candidal vaginitis with inheritance of Lewis blood group antigens. J Infect Dis. 1995;172(6):1616-1619.

Stapleton A, Nudelman E, Clausen H. et al. Binding of uropathogenic Escherichia coli R45 to glycolipids extracted from vaginal epithelial cells is dependent on histo-blood group secretor status. J Clin Invest. 1992;90(3):965-972.

Clausen JO, Hein HO, Suadicani P, Winther K, Gyntelberg F, Pedersen O. Lewis phenotypes and the insulin resistance syndrome in young healthy white men and women. Am J. Hypertens. 1995;8(11):1060-1066.

Hirschberg CB. Golgi nucleotide sugar transport and leukocyte adhesion deficiency II. J Clin Invest. 2001;108(1): 3-6.

Westhoff CM, Reid ME. ABO and Related Antigens and Antibodies. Blood Banking and Transfusion Medicine. 2007;69.