A Review on Scianna Blood Group System


Published: 2023-08-07

DOI: 10.56557/upjoz/2023/v44i173590

Page: 33-36

M. S. Bhosale

Department of Forensic Biology, Institute of Forensic Science, Mumbai-400032, India.

S. A. Kawade *

R. B. Narayanrao Borawake College, Shrirampur, Dist. Ahmednagar-413709, M.S., India.

*Author to whom correspondence should be addressed.


The Scianna blood group system consists of seven antigens expressed on erythrocyte membrane-associated protein (ERMAP) which is encoded by the gene present on the short arm of chromosome 1 at 1p36.2-p22.1 locus which is close to but distinct from Rh locus. The 475 amino acid ERMAP glycoprotein belongs to immunoglobulin superfamily containing a single IgSF domain. It is highly expressed in erythroid tissues. The antibodies of Scianna blood group are clinically less significant. ERMAP glycoprotein is thought to be involved in cell adhesion/receptor, immune recognition and signal transduction.

Keywords: Scianna blood group, ERMAP glycoprotein, IgSF superfamily, erythroid tissues, cell adhesion-receptor

How to Cite

Bhosale , M. S., & Kawade , S. A. (2023). A Review on Scianna Blood Group System. UTTAR PRADESH JOURNAL OF ZOOLOGY, 44(17), 33–36. https://doi.org/10.56557/upjoz/2023/v44i173590


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Spring FA, Herron R, Rowe G. An erythrocyte glycoprotein of apparent Mr 60,000 expresses the Sc1 and Sc2 Antigens. Vox Sanguinis. 1990;58(2):122–125.

Su YY, Gordon CT, Ye TZ, Perkins AC, Chui DHK. Human ERMAP: An erythroid adhesion/receptor trans-membrane protein. Blood Cells Mol Dis. 2001;27:938–949.

Flegel WA, Chen Q, Reid ME, Martin J, Orsini LA, Poole J, Wagner FF. SCER and SCAN: Two novel high-prevalence antigens in the Scianna blood group system. Transfusion. 2005;45(12): 1940–1944.

Ye TZ, Gordon CT, Lai YH, Fujiwara Y, Peters LL, Perkins AC, Chui DH. Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein. Gene. 2000;242(1-2):337–345.

Velliquette RW, Westhoff C, Lomas – Francis C. The effect of proteases or DTT on Scianna antigens, revisited. Transfusion, 51 (Suppl.), 146A [Abstract]; 2011.

Hue-Roye K, Chaudhuri A, Velliquette RW, Fetics S, Thomas R, Balk M, Reid ME. STAR: A novel high-prevalence antigen in the Scianna blood group system. Transfusion. 2005;45(2):245–247.

Brunker PA, Flegel WA. Scianna: The lucky 13th blood group system. Immunohematology. 2011;27(2):41-57.

PMID: 22356519; PMCID: PMC5189634.

Brunker PAR, Flegel WA. An update on the Scianna blood group system. Immunohematology. 2019;35(2): 48-50.

PMID: 31246487; PMCID: PMC6684214.

Arndt PA, Garratty G. A retrospective analysis of the value of monocyte monolayer assay results for predicting clinical significance of blood group alloantibodies. Transfusion. 2004;44:1273 – 1281.

Owen I, Chowdhury V, Reid ME, et al. Autoimmune haemolytic anaemia associated with anti - Sc1. Transfusion. 1992;32:173 – 176.

Nason SG, Vengelen-Tyler V, Cohen N, Best M, Quirk J. A high incidence antibody (anti - Sc3) in the serum of a Sc:–1,–2 patient. Transfusion. 1980;20: 531–535.

Rausen AR, Rosenfield RE, Alter AA et al. A ‘ new ’ infrequent red cell antigen, Rd (Radin). Transfusion. 1967;7: 336–342.

Lundsgaard A, Jensen KG. Two new examples of anti - Rd. A preliminary report on the frequency of the Rd (Radin) antigen in the Danish population. Vox Sang. 1968;14:452–457.

Devine P, Dawson FE, Motschman TL et al. Serologic evidence that scianna null (Sc:–1,–2) red cells lack multiple high-frequency antigens. Transfusion. 1988; 28:346 – 349.

Morton NE, Bruns GA. Report of the committee on the genetic constitution of chromosomes 1 and 2. Human Gene Mapping 9, Cytogenet Cell Genet. 1987; 46:102-130.

Lewis M, Kaita H, Chown B. Scianna blood group system. Vox Sanguinis. 1974;27 (3):261–264.