A Review on Scianna Blood Group System
M. S. Bhosale
Department of Forensic Biology, Institute of Forensic Science, Mumbai-400032, India.
S. A. Kawade *
R. B. Narayanrao Borawake College, Shrirampur, Dist. Ahmednagar-413709, M.S., India.
*Author to whom correspondence should be addressed.
Abstract
The Scianna blood group system consists of seven antigens expressed on erythrocyte membrane-associated protein (ERMAP) which is encoded by the gene present on the short arm of chromosome 1 at 1p36.2-p22.1 locus which is close to but distinct from Rh locus. The 475 amino acid ERMAP glycoprotein belongs to immunoglobulin superfamily containing a single IgSF domain. It is highly expressed in erythroid tissues. The antibodies of Scianna blood group are clinically less significant. ERMAP glycoprotein is thought to be involved in cell adhesion/receptor, immune recognition and signal transduction.
Keywords: Scianna blood group, ERMAP glycoprotein, IgSF superfamily, erythroid tissues, cell adhesion-receptor