Role of Nutraceuticals in Control of Hypertension: A Review

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Published: 2023-09-29

DOI: 10.56557/upjoz/2023/v44i213675

Page: 107-123


Munquad Habibi

Department of Applied Biology, University of Science and Technology Meghalaya (USTM) Techno City, Kling Road, Baridua, 9th Mile, Ri-Bhoi, Meghalaya-793101, India.

Priyanka Shankarishan *

Department of Applied Biology, University of Science and Technology Meghalaya (USTM) Techno City, Kling Road, Baridua, 9th Mile, Ri-Bhoi, Meghalaya-793101, India.

*Author to whom correspondence should be addressed.


Abstract

Nowadays, hypertension is of utmost concern in both developing and developed countries, since it leads to many health problems like cardiovascular disease, heart attack, and stroke. In recent years, many studies were conducted to investigate the effect of nutraceuticals on blood pressure, which are natural food components having pharmacological properties. Nutraceuticals are especially beneficial for pre-hypertensive patients having a little more blood pressure than the normal range, in association with positive lifestyle changes. Even though nutraceuticals have a blood pressure-lowering effect, they cannot replace the conventional method of drug treatment for patients suffering from high blood pressure. Nutraceuticals with blood pressure-lowering activity under different categories like food, nutrients, and non-nutrients are reviewed in this article.

Keywords: Nutraceuticals, blood pressure, BP, hypertension, dietary supplements, cardiovascular disease


How to Cite

Habibi , M., & Shankarishan, P. (2023). Role of Nutraceuticals in Control of Hypertension: A Review. UTTAR PRADESH JOURNAL OF ZOOLOGY, 44(21), 107–123. https://doi.org/10.56557/upjoz/2023/v44i213675

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References

Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217– 23.

Lawes CM, Vanders HS, Rodgers A. Global burden of blood pressure related disease, 2001. Lancet. 2008; 371:1513–8.

McInnes GT. Lowering blood pressure for cardiovascular risk reduction. J Hypertens Suppl. 2005;23: S3–8.

McCartney DM1, Byrne DG, Turner MJ. Dietary contributors to hypertension in adults reviewed. Ir J Med Sci. 2015;84: 81–90.

Joseph P, Leong D, McKee M, Anand SS, Schwalm JD, Teo K, et al. Reducing the global burden of cardiovascular disease, Part 1: The epidemiology and risk factors. Circ Res. 2017;121:677–694.

Borghi C, Cicero AF. Nutraceuticals with a clinically detectable blood pressure-lowering effect: A review of available randomized clinical trials and their meta-analyses. Br J Clin Pharmacol. 2017; 83:163–171.

Chockalingam A. World hypertension day and global awareness. Can. J. Cardiol. 2008;24:441–444.

Pere MI, Musini VM. Pharmacological interventions for hypertensive emergencies: a Cochrane systematic review. J. Hum. Hypertens. 2008;22:596–607.

Appel LJ, Giles TD, Black HR, Izzo JL Jr, Materson BJ, Oparil S, et al. ASH position paper: dietary approaches to lower blood pressure. J Am Soc Hypertens. 2010; 4: 79 – 89.

Domenech M, Roman P, Lapetra J, Garcia de la Corte FJ, Sala-Vila A, de la Torre R, et al. Mediterranean diet reduces 24-hour ambulatory blood pressure, blood glucose, and lipids: one-year randomized, clinical trial. Hypertension. 2014;64:69 – 76.

Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, et al. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension. 2010; 56:274–281.

Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008; 51: 784 – 90.

Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A. Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study. Hypertension. 2015; 65:320–327.

Kanner J, Harel S, Granit R. Betalains—a new class of dietary cationized antioxidants. J Agric Food Chem. 2001; 49: 5178 – 85.

Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: A systematic review and meta-analysis. J Nutr. 2013; 143: 818–26.

Lin LZ, Chen P, Harnly JM. New phenolic components and chromatographic profiles of green and fermented teas. J. Agric. Food Chem. 2008;56:8130–8140.

Liu G, Mi XN, Zheng XX, Xu YL, Lu J, Huang XH. Effects of tea intake on blood pressure: a meta-analysis of randomised controlled trials. Br J Nutr. 2014;112:1043–54.

Habauzit V, Morand C. Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians. Ther Adv Chronic Dis. 2012; 3: 87–106.

Grassi D, Desideri G, Necozione S, Lippi C, Casale R, Properzi G, et al. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr. 2008;138:1671–6.

Grassi D, Desideri G, Necozione S, Ruggieri F, Blumberg JB, Stornello M, et al. Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia. Hypertension. 2012; 60: 827–32.

Cesare R. Sirtori, Anna Arnoldi & Arrigo F. G. Cicero. Nutraceuticals for blood pressure control, Annals of Medicine 2015;47(6):447-456.

Ried K, Sullivan TR, Fakler P, Frank OR, Stocks NP. Effect of cocoa on blood pressure. Cochrane Database Syst Rev. 2012; 8: CD008893.

Reid I, Sullivan T, Fakler P, Frank OR, Stocks NP. Does chocolate reduce blood pressure? A meta-analysis. BMC Med. 2010;8:39– 46.

Desch S, Kobler D, Schmidt J et al. Low vs higher-dose dark chocolate and blood pressure in cardiovascular high-risk patients. Am. J. Hypertens. 2010;23(6): 694–700.

Zarfeshany A, Asgary S, Javanmard SH. Potent health effects of pomegranate. Adv Biomed Res. 2014;3:100.

Sahebkar A, Ferri C, Giorgini P, Bo S, Nachtigal P, Grassi D. Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 2017;115:149–161.

Kelishadi R, Gidding SS, Hashemi M, Hashemipour M, Zakerameli A, Poursafa P. Acute and long term effects of grape and pomegranate juice consumption on endothelial dysfunction in pediatric metabolic syndrome. J Res Med Sci. 2011;16:245–253.

Pathak N, Rai AK, Kumari R, Bhat KV. Value addition in sesame: A perspective on bioactive components for enhancing utility and profitability. Pharmacogn Rev. 2014;8:147–155.

Khosravi-Boroujeni H, Nikbakht E, Natanelov E, Khalesi S. Can sesame consumption improve blood pressure? A systematic review and meta-analysis of controlled trials. J Sci Food Agric. 2017; 97:3087– 3094.

Wichitsranoi J,Weerapreeyakui N, Boonsiri P et al. Antihypertensive and antioxidant effects of dietary black sesame meal in prehypertensive humans. Nutr. J. 2011;10(1):82–88.

Sankar D, Sambandam G, Ramskrishna Rao M, Pugalendi KV. Modulation of blood pressure, lipid profiles and redox status in hypertensive patients taking different edible oils. Clin. Chim. Acta. 2005; 355(1–2):97–104.

Harikumar KB, Sung B, Tharakan ST et al. Sesamin manifests chemopreventive effects through the suppression of NF-kappa-B-regulated cell survival, proliferation, invasion and angiogenic gene products. Mol. Cancer Res. 2010; 8(5):751–761.

Nakano D, Ogura K, Miyakoshi M et al. Antihyptensive effect of angiotensin-Iconverting enzyme inhibitory peptides from a sesame protein hydrolysate inspontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 2006;70(5):1118–1126.

[34]Suetsuna K, Nakano T. Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida). J Nutr Biochem 2000; 11:450–454.

Nakano T, Hidaka H, Uchida J, et al. Hypotensive effects of wakame. J Jpn Soc Clin Nutr. 1998; 20:92.

Sato M, Hosokawa T, Yamaguchi T, et al. Angiotensin I converting enzyme inhibitory peptide derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats. J Agric Food Chem. 2002;50:6245–6252.

Krotkiewski M, Aurell M, Holm G, et al. Effects of a sodium-potassium ion-exchanging seaweed preparation in mild hypertension. Am J Hypertens. 1991;4:483-488.

Lawson LD Garlic: A review of its medicinal effects and indicated active compounds. ACS Symposium Series. 1998;691:177-209.

Lawson LD The composition and chemistry of garlic cloves and processed garlic. Garlic: The science and therapeutic applications of Allium sativum L. and related species. 1996; 37-109.

Ariga T, Seki T. Antithrombotic and anticancer effects of garlic-derived sulfur compounds: A review. Biofactors. 2006;26:93-103.

Bradley JM, Organ CL, Lefer DJ Garlic-derived organic polysulfides and myocardial protection. J Nutr 2016;146:403S-409S.

Simons S, Wollersheim H, Thien T. A systematic review on the influence of trial quality on the effects of garlic on blood pressure. Neth J Med. 2009;67:212- 219.

Reinhard KM, Coleman CI, Teevan C, Vacchani P. Effects of garlic on blood pressure in patients with and without systolic hypertension: A meta-analysis. Ann Pharmacother. 2008;42:1766-1771.

Houston MC. Treatment of hypertension with nutraceuticals. Vitamins, antioxidants and minerals. Expert Rev. Cardiovasc. Ther. 2007;5(4):681–691.

Mozaffarian D, Wu JH. Omega-3 fattyacids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol. 2011;58:2047–2067.

Cicero AF, Ertek S, Borghi C. Omega-3 polyunsaturated fatty acids: their potential role in blood pressure prevention and management. Curr Vasc Pharmacol. 2009;7:330–7.

Miller PE, Van Elswyk M, Alexander DD. Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: a meta-analysis of randomized controlled trials. Am J Hypertens. 2014; 27: 885–96.

Pase MP, Grima NA, Sarris J. Do long-chain n-3 fatty acids reduce arterial stiffness? A meta-analysis of randomised controlled trials. Br J Nutr. 2011;106:974–80.

Cabo J, Alonso R, Mata P. Omega-3 fatty acids and blood pressure. Br J Nutr. 2012; 107 (Suppl 2): S195–S200.

Rebholz CM, Friedman EE, Powers LJ, Arroyave WD, He J, Kelly TN. Dietary protein intake and blood pressure: a meta-analysis of randomized controlled trials. Am J Epidemiol. 2012; 176 (Suppl 7): s27– s43.

Liu XX, Li SH, Chen JZ, Sun K,Wang XJ,Wang XG, et al. Effect of soy isoflavones on blood pressure: a meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2012; 22: 463–70.

FitzGerald RJ, Murray BA, Walsh DJ. Hypotensive peptides from milk proteins. J. Nutr. 2004; 134(4), S980–S988.

Siltari A, Viitanen R, Kukkurainen S, Vapaatalo H, Valjakka J. Does the cis/trans configuration of peptide bonds in bioactive tripeptides play a role in ACE-1 enzyme inhibition? Biologics. 2014;8:59–65.

Cicero AF, Rosticci M, Gerocarni B, Bacchelli S, Veronesi M, Strocchi E, et al. Lactotripeptides effect on office and 24-h ambulatory blood pressure, blood pressure stress response, pulse wave velocity and cardiac output in patients with high-normal blood pressure or first-degree hypertension: a randomized double-blind clinical trial. Hypertens Res. 2011;34: 1035–40.

De Leo F, Panarese S, Gallerani R, Ceci LR. Angiotensin converting enzyme (ACE) in hibitoroy peptides: production and implementation of functional food. Curr. Pharm. Des. 2009;15(31):3622–3643.

Dong JY, Qin JQ, Zhang ZL, Zhao Y, Wang J, Arigoni F, et al. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J. 2011;162: 959–65.

Satake K, Lee JD, Shimizu H, Uzui H, Mitsuke Y, Yue H, et al. Effects of magnesium on prostacyclin synthesis and intracellular free calcium concentration in vascular cells. Magnes Res. 2004;17:20–27.

Soltani N, Keshavarz M, Sohanaki H, Zahedi Asl S, Dehpour AR. Relaxatory effect of magnesium on mesenteric vascular beds differs from normal and streptozotocin induced diabetic rats. Eur J Pharmacol. 2005;508:177–181.

Kass L, Weekes J, Carpenter L. Effect of magnesium supplementation on blood pressure: a meta-analysis. Eur J Clin Nutr. 2012; 66:411–418.

Zhang Xi, Yufeng Li, Del Gobbo L, Rosanoff A, Wang J, Zhang W, et al. Effects of magnesium supplementation on blood pressure a meta-analysis of randomized double-blind placebo-controlled trials. Hypertension. 2016; 68:324–333.

Iqbal S, Klammer N, Ekmekcioglu C. The effect of electrolytes on blood pressure: a brief summary of meta-analyses. Nutrients. 2019;11:pii: E1362.

Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP. Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. BMJ. 2013; 346: f1378.

D’Elia L, Barba G, Cappuccio FP, Strazzullo P. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies. J Am Coll Cardiol. 2011; 57:1210.

Anderson JJ, Kruszka B, Delaney JA, He K, Burke GL, Alonso A, et al. Calcium intake from diet and supplements and the risk of coronary artery calcification and its progression among older adults: 10-year follow-up of the Multi-Ethnic Study of Atherosclerosis (MESA). J Am Heart Assoc. 2016; 5: pii: e003815.

Kopecky SL, Bauer DC, Gulati M, Nieves JW, Singer AJ, Toth PP, et al. Lack of evidence linking calcium with or without vitamin D supplementation to cardiovascular disease in generally healthy adults: a clinical guideline from the National Osteoporosis Foundation and the American Society for Preventive Cardiology. Ann Intern Med. 2016;165: 867–868.

Tankeu AT, Ndip Agbor V, Noubiap JJ. Calcium supplementation and cardiovascular risk: a rising concern. J Clin Hypertens. 2017;19:640– 664.

Bergomi M, Rovesti S, Vinceti M, Vivoli R, Caselgrandi E, Vivoli G. Zinc and copper status and blood pressure. J. Trace Elem. Med. Biol. 1997;11:166–169.

Shahbaz AU, Sun Y, Bhattacharya SK et al. Fibrosis in hypertensive heart disease: molecular pathways and cardioprotective strategies. J. Hypetens. 2010; 28:S25–S32.

Block G, Jensen CD, Norkus EP, Hudes M, Crawford PB. Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young black and white women. Nutr J. 2008; 17:35–46.

Enstrom JE, Kanim LE, Klein M. Vitamin C intake and mortality among a sample of the United States population. Epidemiology. 1992; 3: 194-202.

Houston MC. Nutrition and nutraceutical supplements in the treatment of hypertension. Expert Rev. Cardiovasc. Ther. 2010; 8(6), 821–833.

Juraschek SP, Guallar E, Appel LJ, Miller ER 3rd. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2012; 95:1079–1088.

Sato K, Dohi Y, Kojima M, Miyagawa K. Effects of ascorbic acid on ambulatory blood pressure in elderly patients with refractory hypertension. Arzneimittelforschung. 2006; 56(7), 535–540.

Hanni LL, Huarfner LH, Sorensen OH, et al. Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men. Am J Hypertens. 1995;8:894-901.

Bednarski R, Donderski R, Manitius L. [Role of vitamin D in arterial blood pressure control]. Pol. Merkur. Lekarski. 2007;136:307–310.

Bhandari SK, Pashayan S, Liu IL et al. 25-hydroxyvitamin D levels and hypertension rates. J. Clin. Hypertens. 2011;13(3):170–177.

Cicero AF, Derosa G, Manca M, Bove M, Borghi C, Gaddi AV. Different effect of psyllium and guar dietary supplementation on blood pressure control in hypertensive overweight patients: a six-month, randomized clinical trial. Clin Exp Hypertens. 2007;29:383–94.

Houston MC. Nutrition and nutraceuticals supplements in the treatment of hypertension. Prog Cardiovasc Dis. 2005;47:396–449.

Caligiuri SP, Edel AL, Aliani M, Pierce GN. Flaxseed for hypertension: implications for blood pressure regulation. Curr Hypertens Rep. 2014;16:499.

He J, Whelton PK. Effect of dietary fiber and protein intake on blood pressure: A review of epidemiologic evidence. Clin Exp Hypertens. 1999; 21:785–796.

Li H, Xia N, Förstermann U. Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide. 2012; 26: 102–10.

Liu Y, Ma W, Zhang P, He S, Huang D. Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials. Clin Nutr. 2015;4:27–34.

Feringa HH, Laskey DA, Dickson JE, Coleman CI. The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. J Am Diet Assoc. 2011;111:1173–81.

Rodella LF, Favero G, Foglio E, Rossini C, Castrezzati S, Lonati C, et al. Vascular endothelial cells and dysfunctions: role of melatonin. Front Biosci. 2013; 5:119–129.

Grossman E, Laudon M, Zisapel N. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials. Vasc Health Risk Manag. 2011;7:577–84.

Scheer FA, Morris CJ, Garcia JI, Smales C, Kelly EE, Marks J, et al. Repeated melatonin supplementation improves sleep in hypertensive patients treated with betablockers: a randomized controlled trial. Sleep. 2012; 35:1395–402.

Zaslavskaya RM, Lilitsa GV, Dilmagambetova GS, Halberg F, Cornélissen G, Otsuka K, et al. Melatonin, refractory hypertension, myocardial ischemia and other challenges in nightly blood pressure lowering. Biomed Pharmacother. 2004; 58 (S1): S129–34.

Li X, Xu J. Lycopene supplement and blood pressure: an updated meta-analysis of intervention trials. Nutrients. 2013; 5:3696–3712.

Burton-Freeman B, Sesso HD. Whole food versus supplement: comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors. Adv Nutr. 2014; 5: 457–85.

Maimoona A, Naeem I, Saddiqe Z, Jameel K. A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract. J Ethnopharmacol. 2011;133: 261–77.

Liu X, Wei J, Tan F, Zhou S, Würthwein G, Rohdewald P. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci. 2004; 74: 855–62.

Pravst I, Zmitek K, Zmitek J. Coenzyme Q10 contents in foods and fortification strategies. Critical Reviews in Food Science and Nutrition. 2010; 50(4):269–280.

Langsjoen PH, Langsjoen AM. Overview of the use of CoQ10 in cardiovascular disease. Biofactors. 1999;9:273–84.

Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev. 2009;4:CD007435.

Ankola DD, Viswanas B, Bhardqaj V, Ramarao P, Kumar MN. Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: can the simple nutritional supplement be used as first line therapeutic agents for prophylaxis/ therapy? Eur J Pharm Biopharm. 2007;67:361–9.

Ried K, Fakler P. Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance. Integr Blood Press Control. 2014;7:71–82.

Butt MS, Sultan MT, Butt MS, Iqbal J. Garlic: nature’s protection against physiological threats. Crit Rev Food Sci Nutr. 2009;49:538–51.

Rohner A, Ried K, Sobenin IA, Bucher HC, Nordmann AJ. A systematic review and metaanalysis on the effects of garlic preparations on blood pressure in individuals with hypertension. Am J Hypertens. 2015; 28: 414–23.

Reid K, Frank OR, Stocks NP. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomized controlled trial. Maturitas. 2010; 67:144–150.

Robles-Vera I, Toral M, Romero M, Jime´nez R, Sa´nchez M, Pe´rez-Vizcaı´no F, et al. Antihypertensive effects of probiotics. Curr Hypertens Rep. 2017;19:26.

Antza C, Stabouli S, Kotsis V. Gut microbiota in kidney disease and hypertension. Pharmacol Res 2018; 130:198–203.

Khalesi S, Sun J, Buys N, Jayasinghe R. Effect of probiotics on blood pressure: A systematic review and meta-analysis of randomized, controlled trials. Hypertension. 2014; 64:897–903.