UTTAR PRADESH JOURNAL OF ZOOLOGY

The objective of this study was to design and optimize losartan potassium sustained release and hydrochlorothiazide immediate release formulations. The microbeads are prepared by ionic gellation technique. To evaluate the physical parameters, in-vitro drug release and stability studies formulated tablets were performed. The in-vitro drug release of the optimized formulation was compared with that of the marketed product. Losartan potassium sustained release microbeads offer slow and sustained release of the medication over a period of time. Furthermore Hydrochlorothiazide granules were prepared and then evaluated. The formulation of immediate release granules of hydrochlorothiazide is a promising approach to improve the bioavailability of the drug and reduce its side effects. Hydrochlorothiazide granules allow for a more rapid onset of action, which can be beneficial in patients with acute symptoms. Combining these two medications can be beneficial for patients with hypertension as they can provide both immediate and sustained relief from symptoms.