Evaluation of Analgesic Property of Drynaria quercifolia Rhizome Extract


Published: 2023-10-05

DOI: 10.56557/upjoz/2023/v44i213684

Page: 171-177

R. Jagatheeswari *

PG & Research Department of Biochemistry, Sengamala Thayaar Educational Trust Women’s College (Autonomous), (Affiliated to Bharathidasan University), Sundarakkottai, Mannargudi-614 016, Thiruvarur (Dt.), Tamil Nadu, India.

G. Prasanna

PG & Research Department of Biochemistry, Sengamala Thayaar Educational Trust Women’s College (Autonomous), (Affiliated to Bharathidasan University), Sundarakkottai, Mannargudi-614 016, Thiruvarur (Dt.), Tamil Nadu, India.

*Author to whom correspondence should be addressed.


Analgesics are drugs that primarily relieve pain. The main class of painkillers is narcotics, which include additional drugs that are chemically based on morphine molecules. Phytochemicals are a more recent evolution of the term that highlights most of the plant sources of these protective and preventive compounds. Many herbal preparations are prescribed as analgesics in the traditional literature. The search for new analgesics from a large number of medicinal plant resources is intensifying. In this study, we performed a phytochemical screening and analgesic activity of the bark of Drynaria quercifolia. Phytochemicals have shown that the presence of terpenoids in flavonoids, phenols, saponins, glycosides, alkaloids, polyphenols, proteins, triterpenoids, bark of Drynaria quercifolia has been proven as analgesic activity. Drynaria quercifolia has strong analgesic properties mediated by peripheral and central inhibitory mechanisms. The potential mechanism of action of Drynaria quercifolia may be due to the synergistic action of the phytochemicals present in it. This can provide a justification for the use of this plant in pain and inflammatory diseases in natural medicine.

Keywords: Analgesic activity, medicinal plants, phytochemical, methanolic extract, Drynaria quercifolia

How to Cite

Jagatheeswari , R., & Prasanna , G. (2023). Evaluation of Analgesic Property of Drynaria quercifolia Rhizome Extract. UTTAR PRADESH JOURNAL OF ZOOLOGY, 44(21), 171–177. https://doi.org/10.56557/upjoz/2023/v44i213684


Download data is not yet available.


Merskey H, Bogduk N. (Eds.) Classification of chronic pain. Seattle: IASP; 1994.

Melzack R, Katz J Pain assessment in adult patients. Wall and Melzack's textbook of pain. 2006;291-304.

Kanodia L, Das S. A comparative study of analgesic property of whole plant and fruit extracts of Fragaria vesca in experimental animal models. Bangladesh J Pharmacol. 2008;4:35-38.

Ayanaw MA, Yesuf JS, Birru EM. Evaluation of analgesic and anti-inflammatory activities of methanolic leaf and root extracts of Gomphocarpus purpurascens A. Rich (Asclepiadaceae) in Mice. J Exp Pharmacol. 2023;15 1–11.

Kuritzky Louis. Topical Capsaicin for Chronic Pain. Internal Medicine Alert. 2004;144.

Satyavati GV. Some traditional medical systems and practices of global importance. Indian Journal of Medical Research. 1982;76:1-5.

Sofowara A. Medicinal plants and traditional medicine in Africa. Spectrum Books Ltd, Ibadan, Nigeria. 1993;191-289.

Trease GE, Evans WC. Phenols and Phenolic glycosides. In: Textbook of Pharmacognosy. (12th Ed.). Balliese, Tindall and Co Publishers, London. 1989;343-383.

Harborne JB. Phytochemical Methods. A Guide to Modern Technique of Plant Analysis. London: Chapman and Hall. 1984;15-19.

Koster R, Anderson M, Debeer EJ. Acetic acid for analgesic screening -Fed Proc. 1959;18:412.

Shibata M, Ohkubo T, Takahashi H, et al. Modified formalin test; characteristic biphasic pain response. Pain. 1989;38:347–352.

Janssen PAJ, Niemegeer CJE, Dony JGH. Arzneim Forsch Drug Res. 1963;6:502.

Gene RM, Segura L, Adzet T, Marin E, Iglesias J. Heterotheca inuloides: Anti-inflammatory and analgesic effects. J. Ethnopharmacol. 1998;60:157-162.

Bentley GA, Newton SH, Starr J. Studies on the antinociceptive action of α‐agonist drugs and their interactions with opioid mechanisms. British journal of pharmacology. 1983;79(1):125-134.

Derardt R, Jougney S, Delevalcee F, Falhout M. Release of prostaglandins E and F in algogenic reaction and its inhibition. Eur. J. Pharmacol. 1980;51:17-24.

Roberts JL, Morrow JD. Analgesic–antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout. In: Gilman AG, Hardman JG, Limbird LE, editors. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 10th ed. McGraw Hill Co. New York. 2001;687–731.

Ghule BV, Murugananthan G, Yeole PG. Analgesic and antipyretic effects of Capparis zeylanica leaves. Fitoterapia. 2007;78(5):365-369.

Tjølsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: An evaluation of the method. Pain. 1992; 51(1):5-17.

Bensreti MM, Sewell RD. Selective effects of dopaminergic modifiers on antinociception produced by different opioid receptor agonists. Pro Br Pharmacol Soc. 1983;28:70.

Headley PM, O’Shaughnessy CT. Evidence for opiate and dopamine interaction in striatum. Br J Pharmacol. 1985;86(700):38.

Wigdor SETH, Wilcox GL. Central and systemic morphine-induced antinociception in mice: Contribution of descending serotonergic and noradrenergic pathways. Journal of pharmacology and Experimental Therapeutics. 1987;242(1): 90-95.