Henoch-Schoenlein Purpura: Recent Facts and Treatment Advances

PDF

Published: 2023-11-03

DOI: 10.56557/upjoz/2023/v44i223734

Page: 199-206


Priya Rashmi Choudhury

KMIPSC, Rourkela, Odisha, India.

B. Ray *

IPS, Balasore, Odisha, India.

*Author to whom correspondence should be addressed.


Abstract

HenochSchonlein purpura (HSP) is the most common vasculitis of childhood, affecting 1020 children per 100,000 people each year. More than 90% of patients are under 10 years of age and the median age is 6 years (1, 2). HSP is a leukocytoclastic vasculitis that involves small blood vessels.

HenochSchonlein purpura is an IgAmediated immune vasculitis that involves small blood vessels in the joints, kidneys, gastrointestinal (GI) tract, skin, and less commonly in the central nervous system and lungs. Patients with this disease often present with abdominal discomfort, essential purpura, joint pain, and kidney disease. This review focuses on different aspects of the current disease.

Keywords: Purpura, vessel, leucocyte, chemokines, antibody, immunoglobin


How to Cite

Choudhury , P. R., & Ray , B. (2023). Henoch-Schoenlein Purpura: Recent Facts and Treatment Advances. UTTAR PRADESH JOURNAL OF ZOOLOGY, 44(22), 199–206. https://doi.org/10.56557/upjoz/2023/v44i223734

Downloads

Download data is not yet available.

References

Chen O, Zhu XB, Ren P, Wang YB, Sun RP, Wei DE. Henoch Schoenlein purpura in children: clinical analysis of 120 cases. Afra Health Sci. 2013;13:94–99.

He X, Yu C, Zhao P, Ding Y, Liang X, Zhao Y, et al. The geeentices of Henoch-Schoenlein purpura: a systematic review and meta-analysis. Rheumatol Int. 2013;33:1387–1395.

Yang YH, Tsai IJ, Chang CJ, Chuang YH, Hsu HY, Chiang BL. The interaction between circulating complement proteins and cutaneous microvascular endothelial cells in the development of childhood Henoch-Schonlein purpura. PLoS One. 2015;10:e0120411.

Sohagia AB, Gunturu SG, Tong TR, Hertan HI. Henochschonlein purpura – a case report and review of the literature. Gastroenterol Res Pract. 2010;2010: 597648.

Greer JMJ. Vasculitis associated with malignancy. Experience with 13 patients and literature review. Medicine. 1988;67:220–230.

Kawasaki Y, Suyama K, Hashimoto K, Hosoya M. Methylprednisolone pulse plus mizoribine in children with Henoch Schoenlein purpura nephritis. Clin Rheumatol. 2011;30:529–535.

Bluman J, Goldman RD. Henoch-Schonlein purpura in children: limited benefit of corticosteroids. Can Fam Physician. 2014;60:1007–1010.

Chen J-Y, Mao J-H. Henoch-Schönlein purpura nephritis in children: incidence, pathogenesis and management. World J Pediatr. 2015;11:29–34.

Ozen S, Pistorio A, Iusan SM, Bakkaloglu A, Herlin T, Brik R, et al. EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis.

Matteson EL. Notes on the history of eponymic idiopathic vasculitis: the diseases of Henoch and Scho¨nlein, Wegener, Churg and Strauss, Horton, Takayasu, Behc¸et and Kawasaki. Arthritis Care Res 2000;13:237–245 Ankara 2008. Part II: Final classification criteria. Ann Rheum Dis. 2010;69:798–806.

Davies PJ. Mozart’s death: A rebuttal of Karhausen: Further evidence for Scho¨nlein-Henoch syndrome. J R Soc Med. 1991;84:737–740.

Ballinger S. Henoch-Scho¨nlein purpura. Curr Opin Rheumatol. 2003;15:591– 594.

Mills JA, Michel BA, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of Henoch-Scho¨nlein purpura. Arthritis Rheum. 1990;33:1114–1121.

Kubba AK, Young M. Wolfgang Amadeus Mozart: A case report. J R Coll Surg Edinb. 1996;41:44–47

Gershoni-Baruch R, Broza Y, Brik R. Prevalence and significance of mutations in the familial Mediterranean fever gene in Henoch-Schonlein purpura. J Pediatr. 2003;143:658–661.

Piram M, Mahr A. Epidemiology of immunoglobulin A vasculitis (Henoch-Schönlein): Current state of knowledge. CurrOpinRheumatol. 2013;25(2):171-178.

Trapani S, Micheli A, Grisolia F, et al. Henoch Schonlein purpura in childhood: epidemiological and clinical analysis of 150 cases over a 5-year period and review of literature. Semin Arthritis Rheum. 2005;35(3): 143-153.

Gedalia A. Henoch-Schönlein purpura. Curr Rheumatol Rep. 2004;6(3):195-202.

Pillebout E, Thervet E, Hill G, et al.

López-Mejías R, Castañeda S, Genre F, et al. Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review. Autoimmun Rev. 2018;17(3):301-315.

Weiss PF, Klink AJ, Luan X, et al. Temporal association of Streptococcus, Staphylococcus, and parainfluenza pediatric hospitalizations and hospitalized cases of Henoch-Schönlein purpura. J Rheumatol. 2010;37(12): 2587-2594.

Raymond MS, Spinks J. Bullous Henoch Schonlein purpura. Arch Dis Child. 2012;97:617.

Peru H, Soylemezoglu O, Gonen S, Cetinyurek A, Bakkaloglu SA, Buyan N, et al. HLA class 1 associations in Henoch Schonlein purpura: increased and decreased frequencies. Clin Rheumatol. 2008;27:5–10.

Ghrahani R, Ledika MA, Sapartini G, Setiabudiawan B. Age of onset as a risk factor of renal involvement in Henoch Schönlein purpura. Asia Pac Allergy. 2014; 4:42–47.

Linskey KR, Kroshinsky D, Mihm MC, Jr, Hoang MP. Immunoglobulin-A-associated small-vessel vasculitis: A 10-year experience at the Massachusetts General Hospital. J Am Acad Dermatol. 2012;66: 813–822.

Gardner-Medwin JM, Dolezalova P, Cummins C, Southwood TR. Incidence of henoch-schonlein purpura, kawasaki disease, and rare vasculitides in children of different ethnic origins. Lancet. 2002;360: 1197–202.

DOI: 10.1016/S0140-6736(02)11279-7

Jauhola O, Ronkainen J, Koskimies O, Ala-Houhala M, Arikoski P, Holtta T, et al. Clinical course of extrarenal symptoms in Henoch-Schonlein purpura: A 6-month prospective study. Arch Dis Child. 2010;95:871–6. DOI: 10.1136/adc.2009.167874

Inoue CN, Nagasaka T, Matsutani S, Ishidoya M, Homma R, Chiba Y. Efficacy of early dental and ENT therapy in preventing nephropathy in pediatric Henoch-Schonlein purpura. Clin Rheumatol. 2008;27:1489–96. DOI: 10.1007/s10067-008-0954-5

Da Dalt L, Zerbinati C, Strafella MS, Renna S, Riceputi L, Di Pietro P, et al. Henoch-Schonlein purpura and drug and vaccine use in childhood: a case-control study. Ital J Pediatr. 2016;42:60.

DOI: 10.1186/s13052-016- 0267-2

Piram MGCS, Madhi F, Ulinski T, Mahr A. Vaccination and risk of childhood IgA vasculitis. Pediatrics. 2018;142: e20180841. DOI: 10.1542/peds

Trapani S, Micheli A, Grisolia F, et al. Henoch Schonlein purpura in childhood: epidemiological and clinical analysis of 150 cases over a 5-year period and review of literature. Semin Arthritis Rheum. 2005; 35(3):143-153.

Lu S, Liu D, Xiao J, et al. Comparison between adults and children with Henoch-Schönlein purpura nephritis. Pediatr Nephrol. 2015;30(5):791-796.

Trnka P. Henoch-Schönlein purpura in children. J Paediatr Child Health. 2013; 49(12):995-1003.

Reamy BV, Williams PM, Lindsay TJ. Henoch-Schönlein purpura. Am Fam Physician. 2009;80(7):697-704.

Accessed March 6, 2020. Available:https:// www.aafp.org/afp/2009/1001/p697.html

Sohagia AB, Gunturu SG, Tong TR, et al. Henoch-Schonlein purpura– a case report and review of the literature. Gastroenterol Res Pract. 2010;2010:597648.

Ozen S, Pistorio A, Iusan SM, et al.; Paediatric Rheumatology International Trials Organisation (PRINTO). EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: final classification criteria. Ann Rheum Dis. 2010;69(5):798-806.

Mills JA, Michel BA, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of Henoch-Schonlein purpura. Arthritis Rheum. 1990; 33(8):1114-1121.

Thomas AE, Baird SF, Anderson J. Purpuric and petechial rashes in adults and children: initial assessment. BMJ. 2016;352:i1285.

Chen O, Zhu XB, Ren P, et al. Henoch Schonlein purpura in children: clinical analysis of 120 cases. Afr Health Sci. 2013;13(1):94-99.

Jauhola O, Ronkainen J, Koskimies O, et al. Clinical course of extrarenal symptoms in Henoch-Schonlein purpura: a 6-month prospective study. Arch Dis Child. 2010; 95(11):871-876.

Hetland LE, Sushrut KS, Lindahl KH, et al. Henoch-Schoenlein purpura: A literature review. Acta Derm Venereol. 2017;97(10): 1160-1166.

Menon P, Singh S, Ahuja N, et al. Gastrointestinal manifestations of Henoch-Schoenlein purpura. Dig Dis Sci. 2013; 58(1):42-45.

Chen JY, Mao JH. Henoch-Schoenlein purpura nephritis in children: Incidence, pathogenesis, and management. World J Pediatr. 2015;11(1): 29-34.

Jauhola O, Ronkainen J, Koskimies O, et al. Renal manifestations of Henoch-Schonlein purpura in a 6-month prospective study of 223 children. Arch Dis Child. 2010;95(11):877-882.

Watson L, Richardson AR, Holt RC, et al. Henoch Schoenlein purpura— a 5-year review and proposed pathway. PLoS One. 2012;7(1):e29512.

Chan H, Tang YL, Lv XH, et al. Risk factors associated with renal involvement in childhood Henoch-Schoenlein purpura: A meta-analysis. PLoS One. 2016;11(11): e0167346.

Narchi H. Risk of long term renal impairment and duration of follow up recommended for Henoch-Schoenlein purpura with normal or minimal urinary findings: A systematic review. Arch Dis Child. 2005;90(9): 916-920.

Liu A, Zhang H. Detection of antiphospholipid antibody in children with Henoch-Schoenlein purpura and central nervous system involvement. Paediatric Neurol. 2012;47(3):167-170.

Dudley J, Smith G, Llewelyn-Edwards A, Bayliss K, Pike K, Tizard J. Randomised, double-blind, placebo-controlled trial to determine whether steroids reduce the incidence and severity of nephropathy in Henoch-Schonlein purpura (HSP). Arch Dis Child. 2013;98:756–763.

Jauhola O, Ronkainen J, Autio-Harmainen H, Koskimies O, Ala-Houhala M, Arikoski P, et al. Cyclosporine A vs. methylprednisolone for Henoch-Schonlein nephritis: A randomized trial. Pediatr Nephrol. 2011;26:2159–2166.

Ronkainen JJ. Early prednisone therapy in Henoch-Schönlein purpura: a randomized, double-blind, placebo-controlled trial. J Pediatr/ 2006;149:241–247.

Hahn D, Hodson EM, Willis NS, Craig JC. Interventions for preventing and treating kidney disease in Henoch-Schonlein purpura (HSP). Cochrane Database Syst Rev/ 2015;Cd005128.

Du Y, Hou L, Zhao C, Han M, Wu Y. Treatment of children with Henoch-Schonlein purpura nephritis with mycophenolate mofetil. Pediatr Nephro. 2012;27:765–771.

Xiong J-C, Tian M. Efficacy and safety of mycophenolatemofetil for Henoch-Schonlein purpura nephritis: a systematic review. Chin J Evidence-Based Med. 2014; 14:184–190.

Bech AP, Reichert LJ, Cohen Tervaert JW. Dapsone for the treatment of chronic IgA vasculitis (Henoch-Schonlein). Neth J Med. 2013;71:220–221.

Mazille N, Lipsker D, Fischbach M. Traitement par la dapsone des formescutanéeschroniques du purpura rhumatoide: À propos de 3 cas. Arch Pediatr. 2011;18:1201–1204.

Pillebout E, Rocha F, Fardet L, Rybojad M, Verine J, Glotz D. Successful outcome using rituximab as the only immunomodulation in Henoch-Schonlein purpura: case report. Nephrol Dial Transplant. 2011;26:2044–2046.

Bellan M, Pirisi M, Sainaghi PP. Long-term remission of corticosteroid- and cyclophosphamide-resistant Henoch Schonlein purpura with rituximab. Scand J Rheumatol; 2015 Aug 27. [Epub ahead of print].

Pindi Sala T, Michot JM, Snanoudj R, Dollat M, Esteve E, Marie B, et al. Successful outcome of a corticodependent Henoch-Schonlein purpura adult with rituximab. Case Rep Med. 2014;2014: 619218.

Pillebout E, Alberti C, Guillevin L, Ouslimani A, Thervet E; CESAR study group. Addition of cyclophosphamide to steroids provides no benefit compared with steroids alone in treating adult patients with severe Henoch Schönlein purpura. Kidney Int. 2010;78:495–502.

Kawasaki Y, Ono A, Ohara S, Suzuki Y, Suyama K, Suzuki J, et al. Henoch-Schonlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment. Fukushima J Med Sci. 2013; 59:15–26.

Yan M, Wang Z, Niu N, Zhao J, Peng J. Relationship between chronic tonsillitis and Henoch-Schonlein purpura. Int J Clin Exp Med. 2015;8:14060–14064.

Zurada JMJM. Henoch-Schönlein purpura associated with malignancy in adults. J Am Acad Dermatol; 2006.