Therapeutic Insights into Anti-Inflammatory Activities Derived from Medicinal Plants


Published: 2023-11-20

DOI: 10.56557/upjoz/2023/v44i233769

Page: 95-108

Peter De Roux Sumer

Institute of Pharmacy, Assam Don Bosco University, Tapesia, Assam-782402, India.

Bimal Debbarma

Institute of Pharmacy, Assam Don Bosco University, Tapesia, Assam-782402, India.

Kmensiful Binan

Institute of Pharmacy, Assam Don Bosco University, Tapesia, Assam-782402, India.

Waibiangki Lyngdoh

Institute of Pharmacy, Assam Don Bosco University, Tapesia, Assam-782402, India.

Loushambam Samananda Singh *

Institute of Pharmacy, Assam Don Bosco University, Tapesia, Assam-782402, India.

*Author to whom correspondence should be addressed.


Many synthetic drugs previously considered for treating inflammatory conditions have lost favor due to their potential side effects and adverse outcomes, along with their proven safety concerns for human use. In recent years, herbal remedies have gained popularity as an alternative treatment for a wide range of human ailments. Herbs possessing anti-inflammatory properties have attracted significant attention because they do not have many of the drawbacks associated with synthetic medications. This review aims to provide a comprehensive overview of recently discovered anti-inflammatory compounds falling into various classes of plant constituents, including alkaloids, glycosides, terpenoids, steroids, polyphenolic compounds, and those derived from marine organisms, fungi, and algae. Furthermore, it explores the broader perspective of potential interactions between herbal and synthetic drugs, associated adverse effects, and clinical studies examining the anti-inflammatory properties of herbs.

Keywords: Anti-inflammatory, alkaloids, glycosides, herbal medicine

How to Cite

Sumer, P. D. R., Debbarma , B., Binan , K., Lyngdoh, W., & Singh , L. S. (2023). Therapeutic Insights into Anti-Inflammatory Activities Derived from Medicinal Plants. UTTAR PRADESH JOURNAL OF ZOOLOGY, 44(23), 95–108.


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Bagad AS, Joseph JA, Bhaskaran N and Agarwal A. Comparative evaluation of anti-inflammatory activity of curcuminoids, turmerones, and aqueous extract of Curcuma longa. Adv Pharmacol Sci. 2013;2013:1-7.

Onstantopoulos K. Editorial Hot Topic: Molecular biologypathophysiology of inflammation and autoinflammation. Curr Drug Targets Inflamm Allergy 2005;4:1-39.

Straus DS, Glass CK. Anti-inflammatory actions of PPAR ligands: New insights on cellular and molecular mechanisms. Trends Immunol. 2007;28:551-8.

Straus DS, Glass CK. Anti-inflammatory actions of PPAR ligands: New insights on cellular and molecular mechanisms. Trends Immunol. 2007;28:551-8.

Wallace JL, Ferraz JG. New pharmacologic therapies in gastrointestinal disease. Gastroenterol Clin North Am. 2010;39:709-20.

Marnett LJ. The COXIB experience: a look in the rearview mirror. Annu Rev PharmacolToxicol 2009;49:265-90.

Inotai A, Hanko B, Meszaro A. Trends in the non-steroidal anti-inflammatory drug market in six central-eastern European countries based on retail information. Pharmacoepidemiol Drug Saf 2010;19:183-90.

Vonkeman HE, Van de Laar MA. Nonsteroidal anti-inflammatory drugs: adverse effects and their prevention. Semin Arthritis Rheum. 2010;39:294-312.

Long L, Soeken K and Ernst E. Herbal medicine for the treatment of Osteo Arthritis a Review, Rheumatology. 2001;40:779-93

Rosenson RS. Future role for selective phospholipase A2 inhibitors in the prevention of atherosclerotic cardiovascular disease. Cardiovas Drugs Ther. 2009;23:93-101.

BrooksPM, March LA. New insight into Osteo Arthritis. Med J Aus. 1995;163:367-9.

Philomena G. Concerns regarding the safety and toxicity of medicinal plants - An overview. J Appl Pharmaceut Sci. 2011;1(6):40-4.

Nelson AB, Lau BH, Ide N and Rong Y. Pycnogenolinhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical-induced DNA damage. Drug Dev Ind Pharm. 1998;24:139-44.

Rehman Q, Sack KE. When to try COX-2-specific inhibitors: Safer than standard NSAIDS in some situations. Postgrad Med. 1999;106:95-106.

Fitzgerald GA. Coxibs and cardiovascular disease. N Engl J Med. 2004;351:1709-11.

Harris WS, Von SC. The Omega-3 Index: A new risk factor for death from coronary heart disease, Prev Med .2004;39:212-20.

Fitzgerald GA. Coxibs and cardiovascular disease. N Engl J Med. 2004;351:1709-11.

Hostanska K, Daum G and Saller R. Cytostatic and apoptosisinducing activity of boswellic acids toward malignant cell lines in vitro. Anticancer Res. 2002;22:2853-62.

Mix KS, Mengshol JA, Benbow U, Vincenti MP, Sporn MB, Brinckerhoff CE, et al. A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines. Arthritis Rheum. 2001;44:1096-104.

Schmid B, Lüdtke R, Selbmann HK, Kötter I, Tschirdewahn B, Schaffner W, et al. Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: Randomized placebo-controlled double blind clinical trial. Phytother Res. 2001;15:344-50.

Vane J, Botting. Inflammation and the mechanism of action of anti-inflammatory drugs, The Faseb J. 1987;1:89-96

Chen S. Natural products triggering biological targets - a review of the anti-inflammatory phytochemicals targeting the arachidonic acid pathway in allergy asthma and rheumatoid arthritis. Curr Drug Target. 2011;12(3):288-301.

Khanapure SP, Garvey DS, JaneroDR and Letts LG. Eicosanoids in inflammation: biosynthesis, pharmacology, and therapeutic frontiers. Curr Top Med Chem. 2007;7(3): 311-40.

Chukwuemeka SN, Peter AA. Anti-inflammatory medicinal plants and the molecular mechanisms underlying their activities. Afr J Tradit Complement Altern Med. 2015;12:52-61.

Kumar S, Bajwa BS, Singh K. Kalia AN. Anti-Inflammatory Activity of Herbal Plants: A Review, IJAPBC. 2013;2(2):272-81.

Ferrante A, SeowWK, Rowan-Kelly B. Thong YH. Tetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factoralpha (cachectin) by human monocytes. Clin Exp Immunol .1990;80:232-5.

Teh BS, SeowWK, Li SY, Thong YH. Inhibition of prostaglandin and leukotriene generation by the plant alkaloids tetrandrine and berbamine. J Immunopharmacol. 1990;12:321-6.

Gomes A, Sharma RM, Ghatak BJ. Pharmacological investigation of a glycosidal fraction isolated from Maesachisia D. Don var. angustifolia Hook f and Th. Indian J Exp Biol. 1987;25:826-31

Juteaua F, Masotti V, Bessiere JM, Dherbomez M, Vianoa J. Antibacterial and antioxidant activities of Artemisia annua essential oil. Fitoterapia. 2002;73:532-5.

Mack T, Ammon HP and Safayhi H. Abstracts of the International Joint Symposium of Biology and Chemistry of Active Natural Substances. Bonn. 1990;177.

Choy CS, Hu CM, Chiu WT, Lam CS, Ting Y, Tsai SH, et al. Suppression of lipopolysaccharide-induced of inducible nitric oxide synthase and cyclooxygenase-2 by SanguisDraconis: A dragon's blood resin in raw cells. J Ethnopharmacol. 2008;115:455-62

Dordevic S, Petrovic S, Dobric S, Milenkovic M, Vucicevic D, Zizic S, et al. Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlinaacanthifolia root essential oil. J Ethnopharmacol. 2007;109:458-63.

Passos GF, Fernandes ES, da Cunha FM, Ferreira J, Pianowski LF, Campos MM, et al. Anti-inflammatory and anti- allergic properties of the essential oil and actie compounds from Cordia verbenacea. J Ethnopharmacol. 2007;110: 323-33.

Popov SV, Popova GY, OvodovaRG, Ovodov YS. Antiinflammatory activity of the pecticpolysacharide from Comarumpalustre. Fitoterapia 2005;76:281-7.

Xie G, Schepetkin IA, SiemsenDW, Kirpotina LN, Wiley JA, Quinn MT. Fractionation and characterization of biologicallyactive polysaccharides from Artemisia tripartita. Phytochem 2008; 69:1359-71.

Lim H, Son KH, Chang HW, Sang SS, Kim HP, et al. Effects of antiinflammatorybiflavonoid, ginkgetin on chronic skin inflammation. Biol Pharm Bull. 2006;29:1046-9.

Kwon HM, Choi YJ, JeongYJ, Kang SW, Kang IJ, Lim SS, et al. Anti-inflammatory inhibition of endothelial cell adhesion molecule expression by flavone derivatives. J Agr Food Chem 2005; 53:5150-7.

Bas E, Recio MC, Giner RM, Manez S, Nicholas MC, Rios JL, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideretistragoriganum. Planta Med. 2006;72:136-42.

Breu T, Ustunes L, Lermioglu F, Ozer A. Antiinflammatory, analgesic, and antipyretic effects of an aqueous extract of Erythraeacentaurium. Planta Med. 1991;57:34-7.

Wu Y, Zhou C, Song L, Li X, Shi S, Mo J, et al. Effect of totalphenolics from Laggeraalata on acute and chronic inflammatory models. J Ethnopharmacol. 2006;108:243-50.

Formukong EA, Evans AT, Evans FJ. Analgesic and antiinflammatory activity of constituents of Cannabis sativa L. Inflammation. 1988;12:361-71.

Ko HH, Hung CF, Wang JP and Lin CN. Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G tsugae. Phytochemistry. 2008;69:234-9.

Miller C, Yamaguchi RY, Ziboh VA. Guinea pig epidermis generates putative anti-inflammatory metabolites from fish oil polyunsaturated fatty acids. Lipids 1989;24:998-1003.

Oh PS, Lee SJ, Lim KT. Glycoprotein isolated from Rhusverniciflua Stokes inhibits inflammation-related protein and nitric oxide production in LPS-stimulated raw cell. Biol Pharm Bull. 2007;30:111-6.

Ernst E. Adulteration of Chinese herbal medicines with synthetic drugs: A systematic review. J Intern Med. 2002;252:107-13.

Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis on knee-a randomized double blind placebo controlled trial. Phytomedicine. 2003;10:3-7.

McGettigan P, Henry D. Cardiovascular risk and inhibition of cyclooxygenase: A systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. Jama. 2006;296:1633-44.

Leite PM. Rev Mech Interact Concomitant Use Herbs Warfarin Ther. Biomed Pharmacother 2016;83:14-21.

Rodrigues E, Barnes JJD. Pharmacovigilance of herbal medicines: The potential contributions of ethnobotanical and ethnopharmacological studies. Drug Saf 2013;36(1):1-12.

World health organization. WHO guidelines on safety monitoring of herbal medicines in pharmacovigilance systems. World Health Organization; 2004.

Kunle OF. Standardization of herbal medicines - A review. Int J Biodvers Conserv 2012;4(3):101-12.

Shriwastav A, Gupta SK. Key issues in pilot scale production, harvesting and processing of algal biomass for biofuels. In Algal biofuels. Springer. 2017; 247-58.

World health organization. WHO Global Surveillance and Monitoring System for substandard and falsified medical products; 2017.

Kasilo O, Trapsida JJAHM. Decade Afr Trad Med. 2011;14:25-31.

Bandaranayake WMJMP. Qual Control Screen Toxic Regul Herb Drugs. 2006;10.