Effect of Pimpinella tirupatiensis Extract on Brain Free Radical Toxicity in STZ Induced Diabetic Rats


Published: 2023-11-21

DOI: 10.56557/upjoz/2023/v44i233772

Page: 116-123

D. Veera Nagendra Kumar *

Department of Zoology, Government College for Men (A), Kadapa, Andhra Pradesh, India.

C. Venkata Krishnaiah

Department of Zoology, Government Degree College, Puttur, A.P., India.

V. Gurumurthy

Department of Zoology, Government Degree College for Women, Madanapalle, A.P., India.

G. Seethamma

Department of Zoology, KVR Government College for Women (A), Kurnool, A.P., India.

M. Rama Mohan

Department of Zoology, SV College of Arts & Computer Sciences, Proddatur, AP., India.

C. Narasimha Rao

Department of Zoology, Government Degree College, Mydukur, A.P., India.

*Author to whom correspondence should be addressed.


The objective of this study was to investigate the effects of Pimpinella tirupatiensis on oxidative stress markers in different regions of the brain (cerebral cortex, cerebellum, hippocampus, and Pons medulla) in rats with diabetes. Diabetes was induced in wistar rats by injecting them with STZ (40 mg/kg). The rats were then administered Pimpinella tirupatiensis aqueous extract (750 mg/kg / b.w. /day) and glibenclamide (Glb) (20 mg/ kg / b.w. /day) orally for 30 days. After 4 weeks of high blood sugar, the activity of antioxidant enzymes was measured in both the diabetic and control groups. Diabetes can worsen nerve damage and cause oxidative damage due to high blood sugar levels. The diabetic rats displayed a significant decrease in levels of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase) and reduced glutathione. However, when ginger was administered orally, it enhanced the activity of antioxidant enzymes in the diabetic rats. This suggests that Pimpinella tirupatiensis has a protective effect on the brain by enhancing antioxidant defense mechanisms in diabetic rats. Furthermore, it has a neuroprotective effect by enhancing the brain's antioxidant defense mechanisms and thereby attenuating the progression of hyperglycemia and some complications caused by diabetes in the rat brain.

Keywords: Diabetes, Pimpinella tirupatiensis, SOD, GPx, glutathione, glibenclamide

How to Cite

Kumar, D. V. N., Krishnaiah, C. V., Gurumurthy, V., Seethamma, G., Mohan, M. R., & Rao, C. N. (2023). Effect of Pimpinella tirupatiensis Extract on Brain Free Radical Toxicity in STZ Induced Diabetic Rats. UTTAR PRADESH JOURNAL OF ZOOLOGY, 44(23), 116–123. https://doi.org/10.56557/upjoz/2023/v44i233772


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