Antioxidant Role of Caralluma indica Stem Extract in Isoproterenol Induced Oxidative Stress in Albino Rats

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Published: 2023-12-26

DOI: 10.56557/upjoz/2023/v44i243827

Page: 197-208


R. Shunmuga Vadivu

Department of Biochemistry, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India.

S. Velavan *

Maruthupandiyar College (Affiliated to Bharathidasan University), Thanjavur, Tamil Nadu, India.

*Author to whom correspondence should be addressed.


Abstract

Plants are important for human life on earth and serve as the food. Another important aspect of the plant is therapeutic use. Medicinal plants afford a best source of active compounds to find new medicines that have no adverse effects, such as those that are a very respectable source of disease treatment, that are associated with oxidative stress. Oxidative stress plays a significant role in the pathogenesis of a myocardial infarction (MI) and has been well recognized in the properties of isoproteinol-induced MI.  Current research aims to investigate the role of antioxidants in the Caralluma indica stem extract (CISE) in isoproterenol -induced oxidative stress in albino rats. Depending on the results achieved, CISE can be a suitable candidate to reduce the oxidative stress induced by isoproterenol. CISE management shows an increase in antioxidant status in the treatment of isoproterenol as follows. The cardioprotective properties of CISE can be attributed to the antioxidant components of CISE.


Graphical abstract of antioxidant role of Caralluma indica stem extract

 

Keywords: Medicinal plants, antioxidants, Caralluma indica, oxidative stress, Isoproterenol


How to Cite

Vadivu, R. S., & Velavan , S. (2023). Antioxidant Role of Caralluma indica Stem Extract in Isoproterenol Induced Oxidative Stress in Albino Rats. UTTAR PRADESH JOURNAL OF ZOOLOGY, 44(24), 197–208. https://doi.org/10.56557/upjoz/2023/v44i243827

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References

Kumar S, Sharma S, Vasudeva N. Review on antioxidants and evaluation procedures. Chinese journal of integrative medicine. 2017;6:1-2.

Umaru IJ, Amina AA, Umaru KI, David BC, Haruna DE. Role of antioxidant compounds in promoting healthy ageing. International Journal of Biochemistry Research and Review. 2019; 3:51-63.

Di Meo S, Venditti P. Evolution of the knowledge of free radicals and other oxidants. Oxidative Medicine and Cellular Longevity. 2020;9829176.

Oladeji OS, Odelade KA, Oloke K. Phytochemical screening and anti-microbial investigation of Moringa oleifera leaf extract. African Journal of Science and Technology, Innovation, and Development. 2019;12(1):79-84.

Ushijima H, Monzaki R. An in vitro evaluation of the antioxidant activities of necroptosis and apoptosis inhibitors: the potential of necrostatin-1 and necrostatin-1i to have radical scavenging activities. Pharmacological Reports. 2023;75(2): 490-497.

Moens C, Muller CJ, Bouwens L. In vitro comparison of various antioxidants and flavonoids from Rooibos as beta cell protectants against lipotoxicity and oxidative stress-induced cell death. Plos one. 2022 ;17(5):e0268551.

Khanal LN, Sharma KR, Pokharel YR, Kalauni SK. Phytochemical analysis and in vitro antioxidant and antibacterial activity of different solvent extracts of Beilschmiedia roxburghiana nees stem barks. The Scientific World Journal; 2022.

Tejchman K, Kotfis K, Sieńko J. Biomarkers and mechanisms of oxidative stress—last 20 Years of Research with an emphasis on kidney damage and renal transplantation. International journal of molecular sciences. 2021;22(15):8010.

Kumar V. A review on reactive oxygen and nitrogen species. Era's Journal of Medical Research. 2018;5(1).

Majouli K, Hamdi A, Hlila MB. Phytochemical analysis and biological activities of Hertia cheirifolia L. roots extracts. Asian Pacific Journal of Tropical Medicine. 2017;10(12):1134-1139.

Shahidi F. Antioxidants in food and food antioxidants. Food/ Nahrung. 2000;44(3): 158-163.

Tan BL, Norhaizan ME, Liew WPP, Sulaiman Rahman H. Antioxidant and oxidative stress: a mutual interplay in age-related diseases. Frontiers in pharmacology. 2018;9:1162.

Parthiban E, Arokiyaraj C, Janarthanan S, Ramanibai R. Antioxidant and GC–MS analysis of Annona reticulata leaves extract against unsecure free radicals. SN Applied Sciences. 2019;1: 1-9.

Velavan S, Vadivu RS. Acute and subacute toxicity of ethanol extract of Caralluma indica stem on haematological, biochemical and histology of the liver in rats. World Journal of Science and Research. World. 2020;5(2):01-11.

Beuge JA, Aust SD. the thiobarbituric acid assay. Methods in Enzymology. 1978; 52: 306-307.

Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of SOD. Indian Journal of Biochemistry and Biophysics.1984;21:130-132.

Beers R, Sizer I. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. Journal of Biological Chemistry. 1952;195-133.

Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra,WG. Selenium: biochemical roles as component of glutathione peroxidase. Science. 1973; 179:588-590.

Omaye ST, Tumball JD, Sauberlich HE. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods in Enzymology. 1979;62:1-11.

Baker H, Frank O, De Angeles B, Feinglod S. Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol. Nutrition Reports International. 1980;21:531.

Ochei J, Kolhatkar K. Medical laboratory science. Theory and practice. Tata McGraw-Hill publishing company lit. New Delhi. 2000;234-36.

Diaz-Muñoz M. Älvarez-Perez MA, Yañez L. Vidrio S. Martínez L. Rosas G. Yañez M. Ramírez S. Chagoya de Sánchez. V. Correlation between oxidative stress and alteration of intracellular calcium handling in isoproterenol-induced myocardial infarction. Mol Cell Biochem. 2006;289: 125-136.

Geng ZH, Huang MB, Song YM. Song Protective effect of a polysaccharide from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial injury in rats Carbohydr. Polym. 2015;132:638-642.

Yasuda JM, Okada H, Yamawaki. T3 peptide, an active fragment of tumstatin, inhibits H2O2-induced apoptosis in H9c2 cardiomyoblasts Eur. J. Pharmacol. 2017; 807:64-70.

Zhou RQ, Xu P, Zheng L,Yan J, Zheng G. Dai Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat Eur. J. Pharmacol. 2008;586(1–3):244-250.

Mohan Manu T, Anand T, Sharath Babu GR, Patil MM, Khanum F. Bacopa monniera extract mitigates isoproterenol-induced cardiac stress via Nrf2/Keap1/NQO1 mediated pathway. Archives of Physiology and Biochemistry. 2022;128(2):341-351.

Huang HQ, Geng H, Yao Z, Shen Z, Wu X, Miao. Protective effect of scutellarin on myocardial infarction induced by isoprenaline in rats Iran. J. Basic Med. Sci. 2018;21(3): 267-276.

Dahanukar SA, Kulkarni RA, Rege NN. Pharmacology of medicinal plants and natural products. Indian Journal of Pharmacology. 2000;32:81-118.

Priscilla DH, Prince PSM. Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats, Chemico-Biological Interactions. 2009;179(2-3):118–124.

Saravanan GP, Ponmurugan M, Sathiyavathi S, Vadivukkarasi S, Sengottuvelu. “Cardioprotective activity of Amaranthus viridis Linn effect on serum marker enzymes, cardiac troponin and antioxidant system in experimental myocardial infarcted rats. International Journal of Cardiology. 2013;165(3):494–498.

Ray G, Husain SA. Oxidants, antioxidants and carcinogenesis; 2002.

Lakshmi B, Tilak JC, Adhikari S, Devasagayam TPA, Janardhanan KK. Inhibition of lipid peroxidation induced by γ-radiation and AAPH in rat liver and brain mitochondria by mushrooms. Current Science. 2005;484-488.

Khalil MdI, Tanvir EM, Afroz SA, Sulaiman, GanSH. Cardioprotective effects of tualang honey: amelioration of cholesterol and cardiac enzymes levels. BioMed Research International. Article ID. 2015;286051:8.

Velavan S, Selvarani S, Adhithan A. Cardioprotective effect of Trichopus zeylanicus against myocardial ischemia induced by isoproterenol in rats. Bangladesh J Pharmacol. 2009;4:88-91.

Hussain S, Rao MJ, Anjum MA, Ejaz S, Zakir I, Ali MA, Ahmad S. Oxidative stress and antioxidant defense in plants under drought conditions. In Plant Abiotic Stress Tolerance. 2019;207-219). Springer, Cham.

Halliwell B, Gutteridge JM. The importance of free radicals and catalytic metal ions in human diseases. Molecular aspects of medicine.1985;8(2):89-193.

Erejuwa OO, Sulaiman SAAb, Wahab MS. Honey: a novel antioxidant. Molecules. 2012;17(4): 4400-4423.

Afroz R, Tanvir EM, Karim N. “Sundarban honey confers protection against isoproterenol-induced myocardial infarction in wistar rats,” BioMed Research International. 2016;10.

Pastore A, Federici G, Bertini E, Piemonte F. Analysis of glutathione: implication in redox and detoxification. Clinica Chimica Acta. 2003; 333(1):19-39.

Goraca A, Skibska B. Plasma antioxidant status in healthy smoking and non-smoking men. Bratislavske lekarske listy. 2005;106(10): 301.

Halliwell B, Gutteridge JMC. Free radicals in biology and medicine, 3rd edn. Oxford science publications, Clarendon Press, Oxford University Press, Oxford; 1999.

Wojacki J, Samachowiec L, Conet B, Juzwoak S, Dabrowska K, Zamojen E, Katolonka M. Effect of back wheat extract on free radical generation in rabbits administered high fat diet. Phytother. Res. 1995;15:323-326.

Hassan SM, Khalaf MM, Sadek SA, Abo-Youssef AM. ‘Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice’. Journal of Pharmaceutical and Biomedical Analysis. 2017;55(1):766–774.

Mohamed ME, Abduldaium MS, Younis NS. Cardioprotective Effect of Linalool against Isoproterenol-Induced Myocardial Infarction. Life. 2021;11(2):120.

Maged E, Mohamed Mohamed S, Abduldaium Nancy S, Younis. Cardioprotective Effect of Linalool against Isoproterenol-Induced Myocardial Infarction. 2021;11(120):1-19.

Nandave M, Ojha S, Sujata J, Kumari S, Arya SD. Cardioprotective effect of Bacopa monneira against isoproterenol-induced myocardialnecrosis in rats. Int J Pharmacol. 2007;(3):385-92.

Ojha S, Bhati J, Arora S, Golechha M, Kumari S, Arya DS. Cardioprotective effects of Commiphora mukul against isoprenalineinduced cardiotoxicity: A biochemical and histopathological evaluation. J Environ Biol. 2011;32:731- 8.

Hewitson Tim D, Ian Darby A. Histology Protocols. New York: Humana Press, This laboratory manual looks at tissue preparation and staining, with explanations of complex procedures. 2010;189.

Abi Beaulah G, Mohamed Sadiq A, Sivakumar V, Jaya Santhi R. Cardioprotective activity of ethanolic extract of Croton sparciflorus on isoproterenol induced myocardial infarcted Westar albino rats. ournal of Medicinal Plants Studies.2014;2(6):01-08.

Fathima SN, Murthy SV. Cardioprotective Effects to Chronic Administration of Rosa Damascena Petals in Isoproterenol Induced Myocardial Infarction: Biochemical, Histopathological and Ultrastructural Studies. Biomed Pharmacol J. 2019;12(3).