Study of Anti Melancholy Effect of Tridax procumbens Leaf Extracts

Jayaprakash K *

Department of Pharmacy Practice, PGP College of Pharmaceutical Science and Research Institute, Namakkal-637207, India.

Velmurugan C

Department of Pharmacology, PGP College of Pharmaceutical Science and Research Institute, Namakkal-637207, India.

Venkatesh S

Department of Pharmacy Practice, PGP College of Pharmaceutical Science and Research Institute, Namakkal-637207, India.

Ilanthalir S

Department of Pharmacology, PGP College of Pharmaceutical Science and Research Institute, Namakkal-637207, India.

Parthiban S

Department of Pharmaceutics, PGP College of Pharmaceutical Science and Research Institute, Namakkal-637207, India.

Saranbala V

Department of Pharmacology, JSS College of Pharmacy, Rocklands, Ooty, The Nilgiris, Tamil Nadu, India.

*Author to whom correspondence should be addressed.


Abstract

The current study was intended to assess the antidepressant action of Successive extraction of Petroleum ether (PEETP), Chloroform (CHETP), ethylacetate (EAETP), Ethanolic (EETP) & Aqueous (AETP) extracts of Tridax procumbens (TP)by Tail suspension test (TST). The 25-30g over night fasted mice were selected and divided into six groups. Dose was fixed as per OECD 425 Guidelines acute toxicity studies. Extracts and standard were administered 1 hr prior to study,time period and percentage diminution of immobility were noted. The CETP & EAETP 200 mg/kg extracts shows significant (p<0.01) reduction of immobility time was observed when compared to control. Both EETP 200 mg/kg effect and escitalopram (10mg/kg) shows the more significant (P<0.001) when compared to negative control. AETP was shows p˂0.05 significant whereas PEETP no significant to negative control, the studies result recommends that ethanol extract pronouncedantidepressant effect. It may be the presences of Phtoconstituents attribute the level of Neurotransmitter like 5 hydroxy tryptamine and noradrenaline.

Keywords: Antidepressant, tridax procumbens, tail suspension test, mice, immobility


How to Cite

Jayaprakash K, Velmurugan C, Venkatesh S, Ilanthalir S, Parthiban S, & Saranbala V. (2024). Study of Anti Melancholy Effect of Tridax procumbens Leaf Extracts. UTTAR PRADESH JOURNAL OF ZOOLOGY, 45(7), 83–92. https://doi.org/10.56557/upjoz/2024/v45i73978

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