Advancing Neuroscience through Zebrafish: Challenges, Innovations, and Future Directions

Binaya Sapkota

Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) -Autonomous, Anantapur, Andhra Pradesh, 515721, India.

Syed Shuja Asrar

Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) -Autonomous, Anantapur, Andhra Pradesh, 515721, India.

Bandaru Revanth

Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) -Autonomous, Anantapur, Andhra Pradesh, 515721, India.

Pratiksha Gautam

Department of Pharmacy, Purbanchal University School of Health Science, Gothgaon, Morang, Nepal.

Bidhan Sapkota

KIST Medical College and Teaching Hospital, Imadol, Lalitpur, Nepal.

Kanala Somasekhar Reddy

Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) -Autonomous, Anantapur, Andhra Pradesh, 515721, India.

Praveen Kumar Pasala *

Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) -Autonomous, Anantapur, Andhra Pradesh, 515721, India.

*Author to whom correspondence should be addressed.


Genetic similarity of zebrafish and humans, their transparency, and rapid development has propelled them to be one of the most preferred models for research in neuroscience. Within this article, there is a brief discussion on zebrafish in the field of neuroscience with the considerations of their neuroanatomy, advantages, recent achievements, drawbacks, and the possible routes for future exploration. Zebrafish are a rare model for neuronal development and or translating/creating neurological disorders. Neuroscientists that study zebrafish have occasionally faced problems with behavioral complexity and lack of established methods. Forward-looking actions include optimization of behavioral assays, adoption of CRISPR/Cas9 for genotype modification, and unification of drug discovery and testing of toxicological effects. Through zebrafish neuroscience research, we are heading towards great heights as the potential role in bridging the knowledge on the brain and neurological disorders is very promising. The successful adoption of new technologies and collaborative methods will be the attending factors to reach a goal of zebrafish model fully exploiting the potential for the neuroscience research.

Keywords: Zebrafish, neuroscience, model organism, genetic manipulation, neurodevelopment, behavioral assays, drug discovery

How to Cite

Sapkota, B., Asrar, S. S., Revanth, B., Gautam, P., Sapkota, B., Reddy, K. S., & Pasala, P. K. (2024). Advancing Neuroscience through Zebrafish: Challenges, Innovations, and Future Directions. UTTAR PRADESH JOURNAL OF ZOOLOGY, 45(9), 164–176.


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