Exploring Human Health Benefits from Marine Biomedical Research with Fishes

Vidhya C.S.

Department of Primary Processing Storage and Handling, NIFTEM-Thanjavur, Thanjavur-613005, Tamil Nadu, India.

Susmi Biswas

Haldia Institute of Management, MAKAUT, India.

Sourav Gangopadhyay

Brainware University, Kolkata -700125, India.

Jayeeta Majumder

Brainware University, Kolkata -700125, India.

G Vidyasagar Reddy *

Centurion University of Technology and Management, Pralakhemundi - 761211, Gajapathi Dt., Odisha, India.

Abhijit Debnath

Krishi Vigyan Kendra Dhalai, Tripura-799278, India.

Ashiq Hussain Magrey

Department of Pediatrics, All India Institute of Medical Sciences, Bhopal, MP, India.

K. K. Sivakumar

Mohan Babu University, Sree Sainath Nagar, Tirupati-517 102. Andhra Pradesh, India.

Aparna Srivastava

Department of Food and Nutrition, Era University, Lucknow, India.

Nadiya Afreen

Research Floor Society of India, India.

*Author to whom correspondence should be addressed.


Abstract

Marine organisms, particularly fishes, harbor a treasure trove of bioactive compounds with immense potential for human health applications. In this review, we delve into the diverse array of bioactive molecules derived from marine fishes and their implications for biomedical research. We explore the therapeutic properties of fish-derived compounds, including antimicrobial peptides, omega-3 fatty acids, collagen, and bioactive peptides, among others andthe mechanisms of action and preclinical studies supporting the use of these compounds in various human health conditions, such as cardiovascular disease, cancer, inflammatory disorders, and neurodegenerative diseases. Additionally, we highlight the importance of sustainable sourcing and ethical considerations in marine biomedical research. Overall, this review underscores the significance of marine fishes as a source of novel therapeutic agents and the promising avenues they offer for advancing human health.

Keywords: Marine biomedical research, fishes, bioactive compounds, human health, therapeutic potential


How to Cite

Vidhya C.S., Biswas , S., Gangopadhyay , S., Majumder , J., Reddy , G. V., Debnath , A., Magrey , A. H., Sivakumar , K. K., Srivastava, A., & Afreen , N. (2024). Exploring Human Health Benefits from Marine Biomedical Research with Fishes. UTTAR PRADESH JOURNAL OF ZOOLOGY, 45(11), 59–68. https://doi.org/10.56557/upjoz/2024/v45i114070

Downloads

Download data is not yet available.

References

Mayer AMS, Glaser KB, Cuevas C, Jacobs RS, Kem W, Little RD, McIntosh JM, Newman DJ, Potts BC, Shuster DE. The odyssey of marine pharmaceuticals: a current pipeline perspective. Trends in Pharmacological Sciences. 2010;31(8): 255-65.

Blunt JW, Copp BR, Keyzers RA, Munro MH, Prinsep MR. Marine natural products. Natural Product Reports. 2017;34(3):235-94.

Mayer AMS, Rodríguez AD, Berlinck RG, Hamann MT. Marine pharmacology in 2003–4: marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2007;145(4): 553-81.

Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. Journal of Natural Products. 2007; 70(3):461-77.

Ganesan S, Sahu MK. Marine medicinal foods as potential nutraceuticals: An overview of the pharmacological properties. InMarine Nutraceuticals and Functional Foods. 2020;1-20.

Fleurence J. Seaweed proteins: biochemical, nutritional aspects and potential uses. Trends in Food Science & Technology. 1999;10(1):25-8.

Rani V, Deepak MJ. Nutritional and Functional Properties of Fish and Shellfish Proteins: An Overview. International Journal of Nutrition and Food Sciences. 2015;4(2):143-50.

Mawdsley JL, Brooks AE, Merry F, Griffiths MW, Bolton FJ. Comparison of biochemically active compounds produced by Clostridium botulinum serotype A strains ATCC 3502 and Hall A-hyper. Applied and Environmental Microbiology. 1994;60(12):4386-91.

Goñi I, Valdivieso L, Gudiel-Urbano M. Food components affecting normal flora, intestinal microenvironment and integrity. Nutricion Hospitalaria. 2002;17(4):151-60.

Hermund DB. Digestibility of macroalgal polysaccharides and effects on gut physiology in fish. Aquaculture. 2009;297 (1-4):1-9.

Cian RE, Drago SR. Fish protein hydrolysates: application in deep-fat frying processes. Journal of the American Oil Chemists' Society. 2007;84(4):353-8.

Sheih IC, Fang TJ, Wu TK, Lin PH. Antioxidant properties of a new antioxidative peptide from algae protein waste hydrolysate in different oxidation systems. Bioresource Technology. 2009; 100(13):3419-25.

Kumar N, Krishnakumar K, Jayabalan R, Kumar R, Yun SE. Extraction and Characterization of Collagen from Marine Fish Waste. InProceedings of the Second International Conference on Information and Communication Technology for Competitive Strategies. 2016(ICTCS'16) 2017:245-253.

Himaya SW, Ryu B, Qian ZJ, Kim SK. Sea cucumber, Stichopus japonicus ethyl acetate fraction modulates the lipopolysaccharide induced iNOS and COX-2 via MAPK signaling pathway in murine macrophages. Environmental Toxicology and Pharmacology. 2010;30(3): 68-75.

Ghosh, D., & Ekta Ghosh, D. (2022). A large-scale multi-centre research on domain generalisation in deep learning-based mass detection in mammography: A review. In Acta Biology Forum (pp. 05-09).

Mayer AM, Rodríguez AD, Taglialatela-Scafati O, Fusetani N. Marine pharmacology in 2009-2011: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. Marine drugs. 2013; 11(7):2510-73.

Ghosh, D., & Ekta Ghosh, D. (2022). Intensive training in breast imaging with artificial intel-ligence and deep learning-a review article. In Acta Biology Forum (pp. 18-26).

Schröder HC, Kurz L, Müller WE, Lorenz B. Polyphenols in marine sponge cells. InStudies in Natural Products Chemistry. 2003;28:647-703.

Patankar JV, Becker GL, Zaidi SA, Duggan BM, Hugar KM, Lichtarge O, Nagarajan V, Novick SJ, Sasaki AT, Kearney PL, Tolia NH. Identification of a common glycan epitope unique to structural glycoproteins of the marine sponge Lubomirskia baicalensis. The Journal of Biological Chemistry. 2016;291(10):4972-9.

Bourne DG, Morrow KM, Webster NS. Insights into the coral microbiome: underpinning the health and resilience of reef ecosystems. Annual Review of Microbiology. 2016;70:317-40.

Li F, Ding Y, Wu Q, Zhang J, Zhu D, Chen X, Lu Y. Progress in marine natural products with potential anti-obesity activity. European Journal of Medicinal Chemistry. 2017;139:294-303.

Mayer AM, Rodríguez AD, Taglialatela-Scafati O, Fusetani N. Marine pharmacology in 2009–2011: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. Marine Drugs.

Milad, S. M. A. B. (2022). Antimycotic sensitivity of fungi isolated from patients with Allergic Bronchopulmonary Aspergillosis (ABPA). In Acta Biology Forum (Vol. 1, No. 02, pp. 10-13).

Shawky E, Aboubakr M, El-Gendy A, El-Kafrawy D. Nutritional value and antioxidant activity of some seaweeds from the Red Sea, Egypt. Egyptian Journal of Aquatic Research. 2015;41(1): 1-9.

Silva A, Kačániová M, Alves JA, Oliveira R, Viera M, Moldão M, Barros L, Calhelha RC, Čopíková J, Bujňáková D, C Carvalho AM. Nutritional and nutraceutical potential of seaweeds: An overview. Journal of Agriculture and Environment for International Development (JAEID). 2018; 112(2):189-206.

Ismail MM, Ghaly AS, El-Naggar ME, Al-Mohammady LA. Biochemical studies on the effect of seaweed extract of Ulva lactuca on some biochemical parameters and antioxidant defense system in male rats. Journal of Coastal Life Medicine. 2014;2(1):25-33.

Kumar PS, Al-Dhabi NA, Duraipandiyan V, Balachandran C, Kumar BR. Marine natural products from Microorganisms: Promising candidates for the treatment of cancer. InMicrobial Biotechnology: Volume 1: Applications in Agriculture and Environment. 2018;199-210.

Suleria HA, Masci P, Gobe G, Osborne S. Marine bioactive compounds and health promoting perspectives: innovation pathways for drug discovery. Trends in Food Science & Technology. 2016;50:44-55.

Anantharaju PG, Gowda PC, Vimalambike MG, Madhunapantula SV. An overview on the role of dietary phenolics for the treatment of cancers. Nutrition Journal. 2016;15(1):1-8.

Sikkander AM. Assess of hydrazine sulphate (N2H6SO4) in opposition for the majority of cancer cells. In Acta Biology Forum. 2022;10-13.

Lopes G, Sousa C, Silva LR, Pinto E, Andrade PB, Bernardo J, Mouga T, Valentão P. Can Phlorotannins Purified Extracts Constitute a Novel Pharmacological Alternative for Microbial Infections with Associated Inflammatory Conditions?. PloS One. 2012;7(12): e31145.

Kim YM, Nowack EC, Dawson DH, Lynch OA, Lee JH. Phlorotannins as bioactive agents from brown algae. Process Biochemistry. 2019;82:183-91.

Sikkander, A. M. (2022). Duct cancer evaluation in situ–review. In Acta. Biology Forum (pp. 01-04).

Senthilkumar K, Manivasagan P, Venkatesan J, Kim SK. Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer. International Journal of Biological Macromolecules. 2013;60:366-74.

Wang T, Jónsdóttir R, Ólafsdóttir G. Total phenolic compounds, radical scavenging and metal chelation of extracts from Icelandic seaweeds. Food Chemistry. 2009;116(1):240-8.

Kim SK. Marine cosmeceuticals. In Marine Cosmeceuticals: Trends and Prospects. 2011;1-17.

Rasool A, Kanagaraj T, Mir MI, Zulfajri M, Ponnusamy VK, Mahboob M. Green coalescence of CuO nanospheres for efficient anti-microbial and anti-cancer conceivable activity. Biochemical Engineering Journal. 2022;187:108464.

Kang JY, Khan MNA, Park NH, Cho JY, Lee MC, Fujii H, Hong YK. Anti-inflammatory activity of polysaccharide purified from AMG-assistant extract of Ecklonia cava in LPS-stimulated RAW 264.7 macrophages. Carbohydrate Polymers. 2011;86(4):1551-8.

Phan TT, Hughes MA, Cherry GW. Enhanced proliferation of fibroblasts and endothelial cells treated with an extract of the leaves of Chromolaena odorata (Eupolin), an herbal remedy for treating wounds. Plastic and Reconstructive Surgery. 1998;101(4):756-65.

Nweze CC. Biochemical effects of some preservatives on Vigna unguiculata in Adult Male Wistar Rats. In Acta Biology Forum. 2022;14-23.

Colliec S, Fischer AM, Tapon-Bretaudière J, Boisson-Vidal C. Anticoagulant properties of a fucoidan fraction. Thrombosis Research. 1994;74(3):247-56.

Haugan JA, Liaaen-Jensen S. Isolation and quantification of phlorotannins from brown algae. In Marine Phenolics. 2012; 119-134.

Hamdi HK, Castellon R. A phosphomimetic-based mechanism of dimerization and DNA binding of the cytoplasmic domain of the erythropoietin (EPO) receptor in erythropoiesis. The Journal of Biological Chemistry. 2004;279 (13):1326-34.

Fitton JH, Stringer DN, Park AY, Karpiniec SS. Therapies from fucoidan: An update. Marine Drugs. 2015;13(10): 5920-46.

Suganya A, Santhosh S, Kavitha R, Hemalatha A, Selvamani P, Chidambara Murthy KN. In vitro antioxidant activities of selected seaweeds from Southeast coast of India. Asian Pacific Journal of Tropical Medicine. 2014;7:S512-8.

Hehemann JH, Correc G, Barbeyron T, Helbert W, Czjzek M, Michel G. Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature. 2010;464(7290):908-12.

Dorey ES, Bastida J, Pacheco D, Ortega MJ, Vioque J, Barberá R, Cerdá MJ. Evaluation of the antioxidant properties and oxidative stability of PUFAs-enriched eggs from laying hens fed diets with different sources of fat. Journal of Food Science and Technology. 2016;53(1): 452-62.