Alleviating Ulcer Burdens Examining the Potential of Albizia Odoratissima Bark Extract as a Therapeutic Agent in Mice

M. Tarannum Sultana

Department of Pharmaceutical Analysis, Raghavendra Institute of Pharmaceutical, Education and Research, K R Palli Cross, Chiyyedu, Anantapur-515721, Andhra Pradesh, India.

Shakir Basha *

Department of Pharmaceutical Analysis, Raghavendra Institute of Pharmaceutical, Education and Research, K R Palli Cross, Chiyyedu, Anantapur-515721, Andhra Pradesh, India.

Y. Sai Charan Teja

Department of Pharmacology, Raghavendra Institute of Pharmaceutical, Education and Research, K R Palli Cross, Chiyyedu, Anantapur-515721, Andhra Pradesh, India.

Karthick. S

Department of Pharmaceutical Analysis, Raghavendra Institute of Pharmaceutical, Education and Research, K R Palli Cross, Chiyyedu, Anantapur-515721, Andhra Pradesh, India.

*Author to whom correspondence should be addressed.


Ulcerative stomach disease continues to be a prevalent gastrointestinal illness associated with high worldwide morbidity and medical costs. While nonsteroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection are well-known risk factors for the development of peptic ulcers, recent evidence suggests a complex interaction between host factors and the gut microbiota in ulcer etiology. This study provides a comprehensive review of recent research investigating the relationship between the genesis and progression of peptic ulcers and dysbiosis of the gut microbiota. The study highlights several natural compounds, such as flavonoids, polyphenols, alkaloids, and polysaccharides, that have demonstrated anti-ulcer activity in experimental models and clinical trials. Mechanistic understanding clarifies the many pathways, including antibacterial, anti-inflammatory, and antioxidant ones, through which these drugs perform their medicinal effects. It is interesting to note that many natural compounds focus on many pathogenic procedures that aid in the development and spread of ulcers, resulting in multifactorial effects. Albizia odoratissima is a member of the Fabaceae family and has been used traditionally in many folk medicines due to its medicinal characteristics. This study used experimental models of stomach ulceration to investigate potential anti-ulcer properties of methanolic bark extract from Albizia odoratissima (MAO). The anti-ulcer qualities of MAO were evaluated in rats using models of stomach ulceration brought on by HCL. Many parameters were assessed when different doses of MAO were administered orally, including the ulcer index, mucosal injury to the stomach, mucin content, and antioxidant enzyme levels. Additionally, a histological analysis was carried out to evaluate the possible protective qualities of MAO against harm to the stomach mucosa.

Keywords: Peptic ulcer, gastrointestinal disorder, anti-ulcer activity, anti-oxidant

How to Cite

Sultana, M. T., Basha, S., Teja, Y. S. C., & S, K. (2024). Alleviating Ulcer Burdens Examining the Potential of Albizia Odoratissima Bark Extract as a Therapeutic Agent in Mice. UTTAR PRADESH JOURNAL OF ZOOLOGY, 45(11), 271–284.


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Lau JY, Sung J, Hill C, Henderson C, Howden CW, Metz DC. Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. Digestion. 2011;84 (2):102-13.

Shi HN, Walker WA. Development and physiology of the intestinal mucosal defense. Mucosal immunology: Elsevier. 2015:9-29.

He Q-L, Gao S-W, Qin Y, Huang R-C, Chen C-Y, Zhou F, et al. Gastrointestinal dysfunction is associated with mortality in severe burn patients: A 10-year retrospective observational study from South China. Military Medical Research. 2022;9(1):49.

Bhowmik D, Chiranjib T, Pankaj K. Recent trends of treatment and medication peptic ulcerative disorder. Int J Pharm Tech Research. 2010;2(1):970-80.

Mustafa M, Menon J, Muiandy R, Fredie R, Sein M, Fariz A. Risk factors, diagnosis, and management of peptic ulcer disease. J Dent Med Sci. 2015;14(7):40-6.

Majumdar D, Bebb J, Atherton J. Helicobacter pylori infection and peptic ulcers. Medicine. 2011;39(3):154-61.

Papatheodoridis GV, Sougioultzis S, Archimandritis AJ. Effects of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on peptic ulcer disease: a systematic review. Clinical Gastroenterology and Hepatology. 2006;4(2):130-42.

Lauret M, Pérez I, Rodrigo L. Peptic ulcer disease. Austin J Gastroenterol. 2015;2(5): 1055-63.

Jaiswal F, Rai A, Wal P, Wal A, Singh SP. Peptic ulcer: a review on etiology, pathogenesis and treatment. Asian Journal of Pharmaceutical Education and Research. 2021;10(4):1.

Chan FK, To K, Wu JC, Yung M, Leung W, Kwok T, et al. Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial. The Lancet. 2002;359 (9300):9-13.

Kulshreshtha M, Srivastava G, Singh MP. Pathophysiological status and nutritional therapy of peptic ulcer: An update. Environmental disease. 2017;2(3):76-86.

Riley P. Free radicals in biology: Oxidative stress and the effects of ionizing radiation. International journal of radiation biology. 1994;65(1):27-33.

Martemucci G, Costagliola C, Mariano M, D’andrea L, Napolitano P, D’Alessandro AG. Free radical properties, source and targets, antioxidant consumption and health. Oxygen. 2022;2(2):48-78.

Ahmed OM, Mohammed MT. Oxidative stress: The role of reactive oxygen species (ROS) and antioxidants in human diseases. Plant Arch. 2020;20(2): 4089-95.

Abdulla M, Al-Bayaty F, Younis L, Abu Hassan M. Anti-ulcer activity of Centella asiatica leaf extract against ethanol-induced gastric mucosal injury in rats. Journal of medicinal plants research. 2010; 4(13):1253-9.

Maguire A, Sheahan K. Pathology of oesophagitis. Histopathology. 2012;60(6):864-79.

Potamitis GS, Axon AT. Helicobacter pylori and nonmalignant diseases. Helicobacter. 2015;20:26-9.

Sugawa C, Takekuma Y, Lucas C, Amamoto H. Bleeding esophageal ulcers caused by NSAIDs. Surgical endoscopy. 1997;11:143-6.

Aljaberi HSM, Ansari NK, Xiong M, Peng H, He B, Wang S. Current Understanding of the Transmission, Diagnosis, and Treatment of H. pylori Infection: A Comprehensive Review. Int J Med Phar Drug Re. 2023;7:2.

Huber-Lang M, Henne-Bruns D, Schmitz B, Wuerl P. Esophageal perforation: principles of diagnosis and surgical management. Surgery today. 2006;36:332-40.

Dragstedt LR, Vaughn AM. Gastric ulcer studies. Archives of Surgery. 1924;8(3): 791-810.

Levenstein S, Rosenstock S, Jacobsen RK, Jorgensen T. Psychological stress increases risk for peptic ulcer, regardless of Helicobacter pylori infection or use of nonsteroidal anti-inflammatory drugs. Clinical Gastroenterology and Hepatology. 2015;13(3):498-506. e1.

Singh P, Dhayalan M, Friedman K. Abdominal Pain and Heartburn. Handbook of Medicine in Psychiatry. 2020:169.

Early DS, Ben-Menachem T, Decker GA, Evans JA, Fanelli RD, Fisher DA, et al. Appropriate use of GI endoscopy. Gastrointestinal endoscopy. 2012;75(6): 1127-31.

Vestergaard P, Rejnmark L, Mosekilde L. Proton pump inhibitors, histamine H 2 receptor antagonists, and other antacid medications and the risk of fracture. Calcified tissue international. 2006;79:76-83.

Testerman TL, Morris J. Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment. World journal of gastroenterology: WJG. 2014;20(36): 12781.

Tarasconi A, Coccolini F, Biffl WL, Tomasoni M, Ansaloni L, Picetti E, et al. Perforated and bleeding peptic ulcer: WSES guidelines. World journal of emergency surgery. 2020;15:1-24.

Mayo CH. Gastric and duodenal ulcers. Annals of surgery. 1921;73(3):328-37.

Ng E, Chung S, Sung J, Lam Y, Lee D, Lau J, et al. High prevalence of Helicobacter pylori infection in duodenal ulcer perforations not caused by non-steroidal anti-inflammatory drugs. Journal of British Surgery. 1996;83(12):1779-81.

Dube C, Bursey R, Champion M, Fardy J, Grégoire S, macintosh D, et al. Common symptoms and signs in Gastroenterology. Thomson ABR, Shaffer EA First principles of gastroenterology: The Basis of Disease and Approach to Managment 5th ed Canada: Janssen Ortho. 2011:5-11.

Scully C. Oral and maxillofacial medicine: the basis of diagnosis and treatment: Elsevier Health Sciences; 2012.

Safavi M, Sabourian R, Foroumadi A. Treatment of Helicobacter pylori infection: Current and future insights. World journal of clinical cases. 2016;4(1):5.

Millat B, Fingerhut A, Borie F. Surgical treatment of complicated duodenal ulcers: controlled trials. World journal of surgery. 2000;24:299-306.

Robertson H. Ulcerative gastritis and residual lesions. Journal of the American Medical Association. 1939;112(1):22-7.

Abbass A, Khalid S, Boppana V, Hanson J, Lin H, mccarthy D. Giant gastric ulcers: an unusual culprit. Digestive Diseases and Sciences. 2020;65:2811-7.

Karcioglu O, Yeniocak S, Hosseinzadeh M, Sezgin SB. Abdominal Pain: Essential Diagnosis and Management in Acute Medicine: Bentham Science Publishers; 2022.

Sadiq K, Rizwan B, Noreen S, Fatima A, Sheraz M, Shafqat M, Rashid HM. Determinants of Peptic Ulcer Disease: A Systematic Review. 2020.

Khoder G, Al‑Menhali AA, Al‑Yassir F, Karam SM. Potential role of probiotics in the management of gastric ulcer. Experimental and therapeutic medicine. 2016;12(1):3-17.

Silva MIG, de Sousa FF. Gastric ulcer etiology. Peptic ulcer disease. 2011; 1.

Salleh MR. Life event, stress and illness. The Malaysian journal of medical sciences: MJMS. 2008;15(4):9.

Raffetto JD, Ligi D, Maniscalco R, Khalil RA, Mannello F. Why venous leg ulcers have difficulty healing: Overview on pathophysiology, clinical consequences, and treatment. Journal of clinical medicine. 2020;10(1):29.

Eriksson E, Liu PY, Schultz GS, Martins‐Green MM, Tanaka R, Weir D, et al. Chronic wounds: Treatment consensus. Wound repair and regeneration. 2022;30 (2):156-71.

Gottrup F, Holstein P, Jørgensen B, Lohmann M, Karlsmar T. A new concept of a multidisciplinary wound healing center and a national expert function of wound healing. Archives of Surgery. 2001;136(7): 765-72.

Konturek J. Discovery by Jaworski of Helicobacter pylori. Journal of physiology and pharmacology. 2003;54(S3):23-41.

Tuorkey MJ, Abdul-Aziz KK. Gastric ulcer's diseases pathogenesis, complications and strategies for prevention. 2011.

Kvietys PR, Yaqinuddin A, Al Kattan W. Gastrointestinal Mucosal Defense System: Biota Publishing; 2014.

Slomiany B, Slomiany A. Mucus and gastric mucosal protection. The Stomach: Physiology, Pathophysiology and Treatment: Springer; 1993. p. 116-43.

Miskovitz P, Betancourt M. The Doctor's Guide to Gastrointestinal Health: Preventing and Treating Acid Reflux, Ulcers, Irritable Bowel Syndrome, Diverticulitis, Celiac Disease, Colon Cancer, Pancreatitis, Cirrhosis, Hernias and More: John Wiley & Sons; 2010.

Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada J-R, Stanghellini V. Functional gastroduodenal disorders. Gastroenterology. 2006;130(5):1466-79.

Li Y, Xia R, Zhang B, Li C. Chronic atrophic gastritis: A review. Journal of Environmental Pathology, Toxicology and Oncology. 2018;37(3).

Jaspersen D. Drug-induced oesophageal disorders: pathogenesis, incidence, prevention and management. Drug safety. 2000;22:237-49.

Takeuchi K, Amagase K. Roles of cyclooxygenase, prostaglandin E2 and EP receptors in mucosal protection and ulcer healing in the gastrointestinal tract. Current pharmaceutical design. 2018;24(18):2002-11.

Cho CH. The role of endogenous ulcerogenic mediators in the pathogenesis of peptic ulcer. Life sciences. 1994;55 (20):1521-35.

Rosam A-C, Wallace JL, Whittle BJ. Potent ulcerogenic actions of platelet-activating factor on the stomach. Nature. 1986;319 (6048):54-6.

Amandeep K, Robin S, Ramica S, Sunil K. International Research Journal of Pharmacy.

Parmar N, Desai JK. A review of the current methodology for the evaluation of gastric and duodenal anti-ulcer agents. Indian Journal of Pharmacology. 1993;25 (3):120-35.

Mathew BB, Tiwari A, Jatawa SK. Free radicals and antioxidants: A review. Journal of Pharmacy Research. 2011;4(12):4340-3.

Di Meo S, Venditti P. Evolution of the knowledge of free radicals and other oxidants. Oxidative medicine and cellular longevity. 2020;2020.

Cevik M, Demir T, Karadag CA, Ketani MA, Celik H, Kaplan DS, Boleken ME. Preliminary study of efficacy of hyaluronic acid on caustic esophageal burns in an experimental rat model. Journal of Pediatric Surgery. 2013;48(4):716-23.

Dumanović J, Nepovimova E, Natić M, Kuča K, Jaćević V. The significance of reactive oxygen species and antioxidant defense system in plants: A concise overview. Frontiers in plant science. 2021; 11:552969.

Wallace JL, Sharkey KA. Pharmacotherapy of gastric acidity, peptic ulcers and gastroesophageal reflux disease. Goodman & Gilman’s The pharmacological basis of therapeutics 12th ed San Diego: McGraw-Hill Companies. 2011:1309-22.