UTTAR PRADESH JOURNAL OF ZOOLOGY

This study aimed to characterise the clinical manifestations, cytological features, and pathomorphological characteristics of a rare case of Giant Cell Tumour of Soft Tissue in a six-year-old male Persian cat presented to the Veterinary Clinical Complex with a history of alopecia, persistent pruritus, and multiple raised cutaneous lesions distributed throughout the body. Clinical examination revealed generalised alopecia accompanied by erythematous elevated skin masses measuring ≥3 cm in diameter, predominantly located on the right lateral thoracic region, limbs, and left inguinal area. Haematological evaluation demonstrated anaemia and eosinophilic leucocytosis. Serum biochemistry showed all parameters within normal range. Ultrasonography of abdomen was normal with no impression of metastasis. Cytological analysis revealed high cellularity of pleomorphic multinucleated tumour giant cells that possessed more than 10 nuclei per cell, oval to round shaped nuclei, large prominent nucleoli and tapering cytoplasm that were admixed with numerous neutrophils, lymphocytes and few spindled fibroblasts in the eosinophilic extracellular matrix indicative of reactive inflammation. Histopathologically, it was characterized by presence of numerous large multinucleated giant cells with pleomorphic multiple nuclei arranged in botryose or rosette-like formations among spindle shaped cells. Hence, the case was diagnosed as Giant Cell Sarcoma of Soft Tissue (GCT-ST), which is a rare entity in animals and should be considered in the differential diagnosis of aspirates containing osteoclast-like giant cells.