CO-ENZYME QlO ADMINISTRATION AND ITS EFFECT ON LONG TERM GLYCEMIC CONTROL IN PATIENTS WITH TYPE-2 DIABETES MELLITUS
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Published
Nov 30, 2021
Page:
10-14
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R. SUSSHMITHA
Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences (Affiliated to Bharath Institute of Higher Education and Research), Chennai, Tamil Nadu, India.
A. MANOHARAN
Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences (Affiliated to Bharath Institute of Higher Education and Research), Chennai, Tamil Nadu, India.
Abstract
Diabetic becomes a severe health concern and a pan disease worldwide. Type 2 diabetic (T2D) is majorly seen in the people and its population growth is ever increasing. The glycemic control is a major way in controlling T2D. The prevention and the optimal diagnosis are two major steps for reducing disease burden in the present life style. This study aimed at the effect of coenzyme q 10 supplementation on long term glycemic control (HbA 1 c level) in Type 2 diabetes mellitus (DM2). This study was carried out in Department of Pharmacology and Department of Medicine Bharath Institute of Higher Education and Research, Chennai, Tamilnadu during the period of August 2015 - February 2016 (6months). These results showed that a close relationship is existing between the DM2 and deficient coenzyme Q10 (CoQ10) level. Further, it showed the supplementation of oral hypoglycemic (Biguanide Metformin) could improve glycemic control and blood coenzyme Q10 level positively.
Keywords:
Type 2 diabetes mellitus, coenzyme Q10, mitochondrial dysfunction, oxidative stress, antioxidant, adenosine triphosphate
Article Details
How to Cite
SUSSHMITHA, R., & MANOHARAN, A. (2021). CO-ENZYME QlO ADMINISTRATION AND ITS EFFECT ON LONG TERM GLYCEMIC CONTROL IN PATIENTS WITH TYPE-2 DIABETES MELLITUS. UTTAR PRADESH JOURNAL OF ZOOLOGY, 42(24), 10-14. Retrieved from http://mbimph.com/index.php/UPJOZ/article/view/2640
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Original Research Article
References
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JohnsonAB, Webster JM, Sum CF, et al. The impact of metformin therapy on hepatic glucose production and skeletal muscle glycogen synthase activity in overweight ty pe II diabetic patients. Metabolism. 1993;42: 1217-22
Wollen N, Bailey CJ. Inhibition of hepatic gluconeogenesis by metformin. Synergism with insulin. Biochem Pharmacol. 1988;37:4353-8.
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Robert C. Turner, FRCP; Carole A. Cull, PhD et al., Glycemic Control With Diet, Sulfonylurea, Metformin, or Insulin in Patients With Type 2 Diabetes Mellitus, Progressive Requirement for Multiple Therapies (UKPDS 49), Lancet, 1998; 352:837-853.
Hoda Zahedi, Shahryar Eghtesadi, Soroush Seifirad et al. Effects of CoQJ0 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo - Controlled Trial. 2014;13: 81
Eriksson JG, Forsen TJ, Mortensen SA, Rohde MCA. The effect of coenzyme QJ0 administration on metabolic control in patients with type 2 diabetes mellitus. 1999; 9(2-4):315-318.
Saurabh RamBihariLalShrivastava, Prateek Saurabh Shrivastava et al., Role of self-care in management of diabetes , mellitus, Journal of Dia be l'-, . & Metabolic Disorders. 2013;12:14.
Dawn E. DeWitt, MD, MSc; Irl B. Hirsch, MD, Outpatient Insulin Therapy in Type 1 and T ype 2 Diabetes Mellitus, Scientific Review JAMA. 2003; 289(17):2254-2264.
Christopher Weidner, Prevention and therapy of type 2 diabetes by selective modulation of the human peroxisome proliferator activated receptor gamma (PPARy); 2011, June; PhD Thesis Freie University, Berlin.
Jaakko Tuomilehto, Jaana Lindstrom, Johan G. Eriksson, et al., Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;May 3, 344:1343-1350
Ralph A. DeFronzo. Pharmacologic therapy for type 2 diabetes mellitus. 1999 Aug 17;131(4):281-303.
Bailey CJ, Turner RC. Metformin. N Engl J Med. 1996;334:574 -9.
DeFronzo RA, Goodman AM. Efficacy of metformin in patients with noninsulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med. 1995;333:541-9.
DeFronzo RA, Barzilai N, Simonson DC. Mechanism of metformin action in obese . ,id lean noninsulin-dependent diabetic subjects. J Clin Endocrinol Metab. 1991;73:1294-301.
Stumvoll N, Nurjhan N, Perriello G, et al. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med. 1995;333:550-4.
JohnsonAB, Webster JM, Sum CF, et al. The impact of metformin therapy on hepatic glucose production and skeletal muscle glycogen synthase activity in overweight ty pe II diabetic patients. Metabolism. 1993;42: 1217-22
Wollen N, Bailey CJ. Inhibition of hepatic gluconeogenesis by metformin. Synergism with insulin. Biochem Pharmacol. 1988;37:4353-8.
Cusi K, Consoli A, DeFronzo RA. Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1996;81: 4059-67.
Klip A, Leiter LA. Cellular mechanism of action of metformin. Diabetes Care. 1990;13:696- 70 4.
Overvad K, Diamant B, Holm L, et al. Review Coenzyme QJO in health and disease. 1999 Oct; 53(10):764-70.
Shobha Prakash J. Sunitha, and Mayank Hans, Role of coenzyme Q10 as an antioxidant and bio energizer in Periodontal Diseases. 2010 Dec;42(6):334-337.
Alternative Medicine Review ,Coenzyme QJ0, 2007; 12(2)
Robert Alan Bonakdar, Erminia Guarneri, Coenzyme QJ0, 2005 Sep 15;72(6):1065 -1070.
Robert C. Turner, FRCP; Carole A. Cull, PhD et al., Glycemic Control With Diet, Sulfonylurea, Metformin, or Insulin in Patients With Type 2 Diabetes Mellitus, Progressive Requirement for Multiple Therapies (UKPDS 49), Lancet, 1998; 352:837-853.
Hoda Zahedi, Shahryar Eghtesadi, Soroush Seifirad et al. Effects of CoQJ0 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo - Controlled Trial. 2014;13: 81
Eriksson JG, Forsen TJ, Mortensen SA, Rohde MCA. The effect of coenzyme QJ0 administration on metabolic control in patients with type 2 diabetes mellitus. 1999; 9(2-4):315-318.
Saurabh RamBihariLalShrivastava, Prateek Saurabh Shrivastava et al., Role of self-care in management of diabetes , mellitus, Journal of Dia be l'-, . & Metabolic Disorders. 2013;12:14.
Dawn E. DeWitt, MD, MSc; Irl B. Hirsch, MD, Outpatient Insulin Therapy in Type 1 and T ype 2 Diabetes Mellitus, Scientific Review JAMA. 2003; 289(17):2254-2264.