CO-ENZYME QlO ADMINISTRATION AND ITS EFFECT ON LONG TERM GLYCEMIC CONTROL IN PATIENTS WITH TYPE-2 DIABETES MELLITUS
R. SUSSHMITHA
Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences (Affiliated to Bharath Institute of Higher Education and Research), Chennai, Tamil Nadu, India.
A. MANOHARAN *
Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences (Affiliated to Bharath Institute of Higher Education and Research), Chennai, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
Diabetic becomes a severe health concern and a pan disease worldwide. Type 2 diabetic (T2D) is majorly seen in the people and its population growth is ever increasing. The glycemic control is a major way in controlling T2D. The prevention and the optimal diagnosis are two major steps for reducing disease burden in the present life style. This study aimed at the effect of coenzyme q 10 supplementation on long term glycemic control (HbA 1 c level) in Type 2 diabetes mellitus (DM2). This study was carried out in Department of Pharmacology and Department of Medicine Bharath Institute of Higher Education and Research, Chennai, Tamilnadu during the period of August 2015 - February 2016 (6months). These results showed that a close relationship is existing between the DM2 and deficient coenzyme Q10 (CoQ10) level. Further, it showed the supplementation of oral hypoglycemic (Biguanide Metformin) could improve glycemic control and blood coenzyme Q10 level positively.
Keywords: Type 2 diabetes mellitus, coenzyme Q10, mitochondrial dysfunction, oxidative stress, antioxidant, adenosine triphosphate