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Hyperinsulinemia is correlated with increase in risk of cancer. Our study supports this fact and reveals that insulin acts as a mitogen and increases PC-3 cell proliferation. Increase in metabolism is reflected by the increase in ROS level, since ROS and SOD expression is modulated by insulin. Finally, insulin also leads to increase in MMPs activity, which is related to metastasis. Taken together all these factors we can say that insulin supports tumor progression. In addition to these further studies are required to explore the role of SOD3 in ROS. Temporal and spatial localization of ROS determines its role, as ROS are also essential in signaling process but abnormal increase in ROS level can also have detrimental effect on cells. This complex relationship requires extensive studies.

Hyperinsulinemia, mitogen, PC-3 cell proliferation, insulin, MMPs activity

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