THE ADVERSE DRUG REACTIONS REPORTED IN PSYCHIATRY IN A USING NARANJO’S ASSESSMENT
P. NITHYA
Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences Affiliated to Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
. ANBUCHELLVAM *
Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences Affiliated to Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
The present study analyzes the adverse events caused by the psychotropic drugs during their prevalence. In our study the most commonly prescribed was atypical antipsychotics followed by benzodiazepines, SSRI and others. In the category of antipsychotic drugs the most commonly prescribed was quitiapine and olanzapine which contributed a major part of ADR. Drugs in the atypical antipsychotics like aripiprazole, ziprasidone were prescribed among the 120 patients and proved to have very minimal or no ADR. The drug adverse effects such as cardiotoxicity, particularly arrhythmia could be prevented or minimized by following preventive measures. The usage of safer agents like aripiprazole would help in minimizing the drug adverse interactions. The newly discovered second generation antipsychotic drugs have reduced the incidence of Extra Pyramidal Symptoms (EPS) to the maximum limitation. These results showed that the patients with EPS should be treated with second generation drugs.
Keywords: Adverse drug reaction, pharmacovigilance, reporting causality