Main Article Content
The present study analyzes the adverse events caused by the psychotropic drugs during their prevalence. In our study the most commonly prescribed was atypical antipsychotics followed by benzodiazepines, SSRI and others. In the category of antipsychotic drugs the most commonly prescribed was quitiapine and olanzapine which contributed a major part of ADR. Drugs in the atypical antipsychotics like aripiprazole, ziprasidone were prescribed among the 120 patients and proved to have very minimal or no ADR. The drug adverse effects such as cardiotoxicity, particularly arrhythmia could be prevented or minimized by following preventive measures. The usage of safer agents like aripiprazole would help in minimizing the drug adverse interactions. The newly discovered second generation antipsychotic drugs have reduced the incidence of Extra Pyramidal Symptoms (EPS) to the maximum limitation. These results showed that the patients with EPS should be treated with second generation drugs.
Naranjo C, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA. A method for estimating the probability of adverse drug reactions. Clinical Pharmacology & Theraphy. 1981;30:239-245.
Nasrallah HA. Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Molecular Psychiatry. 2008;13:2735-2738.
Newcomer JW. Second-generation (atypical) antipsychotics and metabolic effects: A comprehensive literature review. CNS Drugs. 2005;19:1-93.
Rao D, Zajecka J, Skubiak,T. The Modified Rush Sexual Inventory: preliminary psychometric findings. Psychiatry Research. 2005;137:175-181.
Rani FA, Byme PJ, Murray ML, Wong IC. Paediatric atypical antipsychotic monitoring safety study (PAMS): pilot study in children and adolescents in secondary and tertiary care settings. Drug Safety. 2009;32:325-33.
Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Atypical Antipsychotic Drugs and the Risk of Sudden Cardiac Death. New England Journal of Medicine 2009;360:225-235.
Rosebraugh CJ, Flockhart DA, Yasuda SU, Woosley RL. Olanzapine- induced rhabdomyolysis. Annals of Pharmacotheraphy. 2001;35:1020-1023.
Wooltorton E. Risperidone (Risperdal): increased rate of cerebrovascular events in dementia trials. Canadian Medical Association. 2002;167:1269-1270.
Rizzieri DA. Rhabdomyolysis after correction of hyponatremia due in psychogenic polydipdsia. Mayo Clinical Proceedings. 1995;70:473-476.
Haro JM, Suarez D, Novick D. Three-year antipsychotic effectiveness in the outpatient care of schizophrenia: observational versus randomized studies results. European Neuropsycho Pharmacology. 2007;17:235-244.
Hasler G, Moergeli H, Bachmann R Patient satisfaction with outpatient psychiatric treatment: the role of diagnosis, pharmacotherapy, and perceived therapeutic change. Canadian Journal of Psychiatry. 2004;49: 315-321.
Tampi R, Shook L, Tampi D. Antidepressant Related Movement Disorders in the Elderly. Current Psychiatry Reviews. 2015;11:116-123.
Skivenes M, Trygstad SC. When whistle-blowing works: The Norwegian case. Human Relations. 2010;63:1071-1097.