EFFECT OF KETAMINE HYDROCHLORIDE ON OVARIAN AND UTERINE ACTIVITIES IN ALBINO RATS

Main Article Content

SOMANTHREDDY C. PATIL
GIRISH RATHOD
MD LIYAKAT AHMED
K. VIJAYKUMAR

Abstract

Ketamine hydrochloride at the dose levels of 1mg and 3mg/100 g body weight was administered to normal cycling rat for 20 days through intraperitoneal routes. At autopsy on 21st day significant reduction in the ovarian and uterine weight was observed. Histological observations showed decrease in the number and size of graafian follicles, corpora lutea and increase in the atretic follicles in the ovary. The uterus showed absence of endometrial glands, decrease in the height of myometrium, endometrium and its epithelial cells. The total protein and glycogen content of the ovary and uterus is decreased whereas the cholesterol content is increased. This action of ketamine hydrochloride to gonadotrophins is discussed.

Keywords:
Ketamine hydrochloride, atretic follicles, ovarian steroids

Article Details

How to Cite
PATIL, S. C., RATHOD, G., AHMED, M. L., & VIJAYKUMAR, K. (2021). EFFECT OF KETAMINE HYDROCHLORIDE ON OVARIAN AND UTERINE ACTIVITIES IN ALBINO RATS. UTTAR PRADESH JOURNAL OF ZOOLOGY, 42(24), 470-474. Retrieved from http://mbimph.com/index.php/UPJOZ/article/view/2730
Section
Original Research Article

References

Laskowski K, Stirling A, McKay WP, Lim HJ. A systematic review of intravenous ketamine for postoperative analg esia. Can J Anaesth. 2011;58(10):911-23.

Corriger A, Pickering G, “Ketamine and depression: A narrative re-view. Drug Des Devel Ther. 2019;13:3051-67.

Orhurhu VJ, Roberts JS, Ly N, Cohen SP. Ketamine in acute and chronic pain management. In: Stat-Pearls, edn. Eds. Treasure Island: StatPearls Publishing; 2020.

Maher DP, Chen L, Mao J. “Intravenous ketamine infusions for neuropathic pain management: a promising therapy in need of optimization. Anesth Analg . 2017;124(2):661-74.

Anghelescu DL, Tesney JM. Neuropathic pain in pediatric oncology: A clinical decision algorithm. Paediatr Drug. 2019;21(2):59-70.

Louer R, McKinney RC, Abu-Sultaneh S, Lutfi R, Abulebda K. Safety and efficacy of a propofol and ketamine based procedural sedation protocol in children with cerebral palsy undergoing botulinum toxin a injections. American Academy of Physical Medicine and Rehabilitation. 2019;12:1320-1325.

Duman RS. The Dazzling Promise of Ketamine. Cerebrum. 2018;04-18.

Chomchai S, Phuditshinnapatra J, Mekavuthikul P, Chomchai C. Effects of unconventional recreational drug use in pregnancy. Semi Fetal Neonatal Med. 2019(2): 142-148

Petrenko AB, Yamakura T, Askalany AR, Kohno T, Sakimura K, Baba H. “Effects of ketamine on acute somatic nocieption in wild-type and N-methyl-D-aspartate(NMDA) receptor epsilon1 subunit knockout mice”. Neuropharmacology. 2006;50(6):741-7.

Bergman SA. Ketamine: Review of its pharmacology and its use in pediatric anesthesia. Anesth Prog. 46:10- 20.

Wang YC, et al. Breaking the drug addiction cycle is not easy in ketamine abusers. Inter-national Journal of Urology. 2010;17:496-497

Kalsi SS, Wood DM, Dargan PI. The epidemiology and patterns of acute and chronic toxicity associated with recreational ketamine use. Emerging Health Threats Journal. 2011; 4(1):7107.

Morgan CJA, Curran HV. The Independent Scientific Committee on Drugs (ISCD), Ketamine use: A review. Addiction. 2012; 107(1):27–38.

Keilhoff G, Becker A, Grecksch G, Wolf G, Bernstein HG. Repeated application of ketamine to rats induces changes in the hippocampal expression of parvalbumin, neuronal nitric oxide synthase and cFOS similar to those found in human schizophrenia. Neuroscience. 2004;126(3): 591–598.

Cunha-Oliveira T, Rego AC, Cardoso SM, et al. Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine. Brain Research. 2006;1089(1):44–54, 2006.

Ivan Ezquerra-Romano W, Lawn E, Krupitsky CJ, Morgan A. Ketamine for the treatment of addiction: Evidence and potential mechanisms. Neuropharmacology. 2018;142: 72-82.

Yee CH, Teoh JYC, Lai PT, Leung VYF, Chu WCW, Lee WM et al. The Risk of Upper Urinary Tract Involvement in Patients with Ketamine-Associated Uropathy. Int Neurourol J. 2017;21:128-132.

Sanjay VS, Joshi BN. Melatonin and exposure to constant light/ darkness affects ovarian follicular kinetics and estrous cycle in Indian desert gerbil Meriones hurrianae (Jerdon). Gen. Comp Endocrinol. 1997;108:352-357.

Lowry OH, Rosenbrough NJ, Farr NL and Randall RJ(Protein measurement with Folic-Phenol-Reagent. J Biol Chem. 1951;193:265-275.

Peters JP, Van Slyke DD. Quantitative Clinical Chemistry, Vol-1, Williams and Wilkins;1946.

Corrol NV, Langely RW and Row RH. Glycogen determination in liver and muscle by use of anthrone reagent. J Biol Chem. 1956;20: 583-593.