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Breast cancer is recorded as the one of the most common carcinomas in woman and causing approximately 22% death in female population worldwide. Nearly, 26% of the women are affected in developing and under developed countries. The areas of affluent populations with high risks are North America, Europe, and Australia. The breast cancer evolved as a commonest cancer among Indian women and followed by cervix cancer. Nationally, 19-34% of all cancer accounts among women. All the data are collected from in our country of India. In the present study, 80 cases of Invasive carcinoma of breast were studied. 50 cases were subjected to immune histochemistry Non-biotin HRP system is superlative system for diagnosing the BC and the results showed that the p53 oncoprotein over expression was 30%. Nuclear p53 accumulation can be associated with high morphological grade in general and with tumor cell proliferation and not necessarily with biological aggressiveness. P53 over expression was significantly seen in poorly differentiated nuclear grade tumors.
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