THE HISTOPATHOLOGY AND PREDICTIVE INDICES OF CARCINOMA BREAST WITH SPECIAL REFERENCE TO p53 MARKER
Article Sidebar
Main Article Content
Abstract
Breast cancer is recorded as the one of the most common carcinomas in woman and causing approximately 22% death in female population worldwide. Nearly, 26% of the women are affected in developing and under developed countries. The areas of affluent populations with high risks are North America, Europe, and Australia. The breast cancer evolved as a commonest cancer among Indian women and followed by cervix cancer. Nationally, 19-34% of all cancer accounts among women. All the data are collected from in our country of India. In the present study, 80 cases of Invasive carcinoma of breast were studied. 50 cases were subjected to immune histochemistry Non-biotin HRP system is superlative system for diagnosing the BC and the results showed that the p53 oncoprotein over expression was 30%. Nuclear p53 accumulation can be associated with high morphological grade in general and with tumor cell proliferation and not necessarily with biological aggressiveness. P53 over expression was significantly seen in poorly differentiated nuclear grade tumors.
Article Details
References
Khokar N, Gill ML. Gastrointestinal injury from non-steroidal anti-inflammatory drugs. Rawal Medical Journal 2003;28:22-24.
Anderson J, Anderson JV, Baker LRI, Benjamin N, Black GM, Borroughs AK. Gastrointestinal disease. Clinical Medicine. 2002;1: 270-272.
Minhas KZ, Goraya F, Javid S, Shakoor A, Rizwan A, HashmiMT. Endoscopic and Histopathological evaluation of 306 Dyspepsic patients. Pakistan Journal of Gastroentrology. 2003;17:4-7.
Rubin C. Are there three types of Helicobacter pylori gastritis? Gastroenterology. 1991;112: 2108.
Bhattacharya B, Montgomery E. Non-neoplastic disorders of the stomach. Gastrointestinal and Liver Pathology. 2005; 1:66-125.
Dheer S, Levine MS, Redfern RO. Radiographically diagnosed antral gastritis: Findings in patients with and without Helicobacter pylori infection. Brazilian Journal of Radiology. 2002;75:805.
Appelman H. Gastritis: Terminology, etiology, and clinicopathological correlations-another biased view. Human Pathology. 1994; 25:1006.
Le HT, Murugesan A, Ramesh T, Yli-Harja O, Mani SK, Kandhavelu M. Molecular interaction of HIC, an agonist of P2Y1 receptor, and its role in prostate cancer apoptosis. International Journal of Biological Macromolecules. 2021;189:142-150.
Le HT, Rimpilainen T, Mani SK, Murugesan A, Yli-Harja O, Candeias NR, Kandhavelu M. Synthesis and preclinical validation of novel P2Y1 receptor ligands as a potent anti-prostate cancer agent. Scientific reports. 2019; 9:18938.
Meenakshi SK, Nagarajan M, Sundararaman M. Brine shrimp cytotoxicity was not warrant for teratogenicity: Comparative analysis of seaweed methanolic extracts collected from Tamil Nadu coastal region on brine shrimp and zebra fish embryos. Research & Reviews: A Journal of Life Sciences. 2018;8:24–32.
Meenakshi Sundarm K, Uma D, Rajakumar M. In silico Discovery of Seaweed Molecules against Matrixmet all oproteinase-26. Journal of Advanced Bioinformatics Applications and Research. 2015;6:52-61
Kim SW, Roh J, Park CS. Immunohistochemistry for pathologists: protocols, pitfalls, and tips. Journal of Pathology and Translational Medicine. 2016;50:411.
Carneiro A, Barbosa ÁR, Takemura LS, Kayano PP, Moran NK, Chen CK, Wroclawski ML, Lemos GC, Cunha IW, Obara MT, Tobias-Machado M. The role of immunehistochemical analysis as a tool for the diagnosis, prognostic evaluation and treatment of prostate cancer: A systematic review of the literature. Frontiers in oncology. 2018;8:377.