A STUDY ON ANALGESIC EFFECT OF Syzygium aromaticum IN ALBINO RATS USING INTRAPERITONEAL INJECTION
SENTHIL KUMAR
Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences Affiliated to Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
. SOMASUNDARAM *
Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences Affiliated to Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
The current study's goal was to assess the effect of clove bud powder on analgesia, which had never been done before. In the rat formalin test, the normal saline through control group received normal saline (3 ml/kg). The second, and followed by third and fourth groups traditional ketorolac (1S mg/kg intra-peritoneal injection), syzygium aromaticum powder 100 mg/kg and 200 mg/kg, respectively. The results found for the control showed a biphasic pam response with an instant and short torrent of activity lasting around the first 5 min, followed by a prolonged passes of activity starting at minute 11, peaking between 10 to 30 min. Tiny nociceptive performance was observed during a 5-min erratic between the 6-10 minutes. Our results revealed that the nociception seen in phase 1 is a result of direct nerve stimulation by the formalin. Further, it has been demonstrated that the nociception produced in phase 2 of the formalin test is a result of chemical insult resulting in tissue damage.
Keywords: Analgesic, Syzygium Aromaticum, Albino Rats, Intraperitoneal Injection