A REVIEW ON ANTICANCER SOURCES FROM AQUATIC ORGANISMS
UTTAR PRADESH JOURNAL OF ZOOLOGY,
Page 57-67
Abstract
Now a days the prevalence of cancer is increasing in an alarming way. There are several treatment methods for the control of cancer cells including chemotherapy, radiation, and surgery. Chemotherapy, that uses chemicals for the inhibition of cancer growth and out-turn leads to several side effects to the normal cells. Naturally derived substances are getting more attention in cancer studies as a replacement of the chemicals or enhancers of chemicals used in chemotherapy. This review intends to gives a brief account on the recently found anticancer activity of aquatic organisms or compounds.
Keywords:
- Cancer
- cytotoxicity
- aquatic microorganisms
- aquatic plants
- aquatic algae
- fish
How to Cite
APARNA, J., & AMPILI, M. (2021). A REVIEW ON ANTICANCER SOURCES FROM AQUATIC ORGANISMS. UTTAR PRADESH JOURNAL OF ZOOLOGY, 42(22), 57-67. Retrieved from https://mbimph.com/index.php/UPJOZ/article/view/2564
References
Cancer. Available:https://www.who.int/en/news-room/fact-sheets/detail/cancer Accessed: September 2021.
Amin ARMR, Kucuk O, Khuri FR, Shin DM. Perspectives for cancer prevention with natural compounds. Journal of clinical oncology: Official Journal of the American Society of Clinical Oncology 2009;27(16):2712– 25. DOI: 10.1200/JCO.2008.20.6235
Calcabrini C, Catanzaro E, Bishayee A, et al. Marine Sponge Natural Products with Anticancer Potential: An Updated Review. Marine Drugs. 2017;15(10):310. Doi: 10.3390/md15100310
Lai P, Roy J. Antimicrobial and Chemopreventive Properties of Herbs and Spices. Current Medicinal Chemistry. 2004;11(11):1451–1460. DOI: 10.2174/0929867043365107
Klausmeyer P, Chmurny GN, Mccloud TG, et al. A Novel Antimicrobial Indolizinium Alkaloid from Aniba panurensis. Journal of Natural Products. 2004;67(10):1732–1735.
El-Seedi HR, Sata N, Torssell KBG, Nishiyama S. New labdene diterpenes from Eupatorium glutinosum. Journal of Natural Products. 2002;65(5):728–729. DOI: 10.1021/np010595r
Faulkner DJ. Marine natural products. Natural Product Reports. 2001;18(1):1–49. DOI: 10.1039/b006897g
Ireland CM, Molinski TF, Roll DM, et al. Natural Product Peptides from Marine Organisms. In: Bioorganic Mar. Chem. 1989;l1–46.
Saadaoui I, Rasheed R, Abdulrahman N, et al. Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential. Marine Drugs. 2020;18(4):197. DOI: 10.3390/md18040197
Correia-da-Silva M, Sousa EE, Pinto MMM, Kijjoa A. Anticancer and cancer preventive compounds from edible marine organisms. Seminars in Cancer Biology. 2017;46(5):55–64. DOI: 10.1016/j.semcancer.2017.03.011
Chakraborty C, Hsu C-H, Wen Z-H, Lin C-S. Anticancer Drugs Discovery and Development from Marine Organisms. Current Topics in Medicinal Chemistry. 2009;9(16):1536–1545. DOI: 10.2174/156802609789909803.
Yang P, Cartwright C, Ding J, et al. Anticancer Activity of Fish Oils against Human Lung Cancer Is Associated with Changes in Formation of PGE2 and PGE3 and Alteration of Akt Phosphorylation. Mol Carcinog. 2014;53(7):566–577. DOI: 10.1016/j.physbeh.2017.03.040
Carballeira NM. New advances in fatty acids as antimalarial, antimycobacterial and antifungal agents. Progress in Lipid Research. 2008; 47(1):50–61. DOI: 10.1016/j.plipres.2007.10.002
Malaker A, Adil S, Ahmad I, et al. Therapeutic potency of anticancer peptides. Journal of Engineering And Applied Sciences. 2013;2 (3):82–94.
Newman DJ, Cragg GM. Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development. Marine Drugs. 2014 ;12(1):255–278. DOI: 10.3390/md12010255
Newman DJ, Cragg GM. Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010. Journal of Natural Products. 2012;75(3):311–335. DOI: 10.1021/np200906s
Nobili S, Lippi D, Witort E, et al. Natural compounds for cancer treatment and prevention. Pharmacological Research. 2009;59 (6):365–378. DOI: 10.1016/j.phrs.2009.01.017
Aquatic Organisms: Microorganisms. Available:http://www.ramp-alberta.org/river/ecology/life/microorganisms.aspx Accessed: September 2021.
Suja M, Vasuki S, Sajitha N. Anticancer Activity of Compounds Isolated From Marine Endophytic Fungus Aspergillus Terreus. World Journal of Pharmacy and Pharmaceutical Sciences. 2014;3(6):661– 672.
Dhaneesha M, Sajeevan TP. Anticancer Activity of Sponge Associated Actinomycetes Streptomyces sp. MCCB267 On Lung Cancer Cell Line. Proceedings of 28th Kerala Science Congress. 2016;1628–39.
Pham HT, Nguyen NP, Phi TQ, et al. The Antibacterial and Anticancer Activity of Marine Actinomycete Strain HP411 Isolated in the Northern Coast of Vietnam. World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering. 2014;8(12):780–784.
Wijaya AP, Bondar KG, Frederick EH, et al. Identification of marine bacteria HPP.4A and HPP.T13 and its anticancer activity against P388 murine leukaemia cell. IOP Conference Series: Earth and Environmental Science. 2020;584 (1):0–6. DOI: 10.1088/1755-1315/584/1/012005
Weisse T. Functional diversity of aquatic ciliates. European Journal of Protistology. 2017;61:331–358. DOI: 10.1016/j.ejop.2017.04.001
Calow J, Behrens AJ, Mader S, et al. Antibody production using a ciliate generates unusual antibody glycoforms displaying enhanced cell-killing activity. mAbs. 2016;8(8):1498–1511. DOI: 10.1080/19420862.2016.1228504
Carpi S, Polini B, Poli G, et al. Anticancer activity of euplotin C, isolated from the marine ciliate euplotes crassus, against human melanoma cells. Mar Drugs; 2018. DOI: 10.3390/md16050166
Beneficial Aquatic Plants. Available:https://www.aquaticbiologists.com/beneficial-plants/ Accessed: September 2021.
Aquatic Organisms: Plants - Regional Aquatics Monitoring Program (RAMP). http://www.ramp-alberta.org/river/ecology/life/plants.aspx Accessed: September 2021.
Freshwater algae: Native plants; 2017. Available:https://www.doc.govt.nz/nature/native-plants/freshwater-algae/ Accessed: September 2021.
Awati SS, Singh SK, Wadkar KA. In vitro Antioxidant potential and Anticancer activity of Ceratophyllum demersum Linn. extracts on HT-29 human colon cancer cell line. Research Journal of Pharmacy and Technology. 2021;14 (1):28–36. DOI: 10.5958/0974-360X.2021.00006.8
Lenora LM, Senthil Kumar J, Murugesan S, Senthilkumar N. Anticancer Activity of Water Hyacinth [ Eichhornia Crassipes (Mart) Solms] on Human Cervical Cancer Cell Line. Octa Journal of Environmental Research. 2015; 3(4):327–331.
Saeed AM, Abotaleb SI, Alam NG, et al. In vitro assessment of antimicrobial, antioxidant and anticancer activities of some marine macroalgae. Egyptian Journal of Botany. 2020;60(1):81–96. DOI: 10.21608/ejbo.2019.11363.1303
Hemasudha T., Thiruchelvi R, Balashanmugam P. Antioxidant, antibacterial, and anticancer activity from marine red algae gracilaria edulis. Asian Journal of Pharmaceutical and Clinical Research. 2019;12(2):276–279. DOI: 10.22159/ajpcr.2019.v12i2.29883
Miranda-Delgado A, Montoya MJ, Paz-Araos M, et al. Antioxidant and anti-cancer activities of brown and red seaweed extracts from chilean coasts. Latin American Journal of Aquatic Research. 2018;46(2):301–313. DOI: 10.3856/vol46-issue2-fulltext-6
Lezcano V, Fernández C, Parodi ER, Morelli S. Antitumor and antioxidant activity of the freshwater macroalga Cladophora surera. Journal of Applied Phycology. 2018;30(5): 2913–2921. DOI: 10.1007/s10811-018-1422-5
Marudhupandi T, Ajith Kumar TT, Lakshmanasenthil S, et al. In vitro anticancer activity of fucoidan from Turbinaria conoides against A549 cell lines. International Journal of Biological Macromolecules. 2015;72:919–23. DOI: 10.1016/j.ijbiomac.2014.10.005
Aquatic Organisms: Invertebrates - Regional Aquatics Monitoring Program (RAMP). Available:http://www.ramp-alberta.org/river/ecology/life/invertebrates.aspx Accessed: September 2021.
Ciftci HI, Can M, Ellakwa DE, et al. Anticancer activity of Turkish marine extracts: A purple sponge extract induces apoptosis with multitarget kinase inhibition activity. Investigational New Drugs. 2020;38(5):1326–1333. DOI: 10.1007/s10637-020-00911-8
Eltamany E, Eltahawy N, Ibrahim A, et al. Anticancer Activities of Some Organisms from Red Sea, Egypt. Catrina: The International Journal of Environmental Sciences. 2014;9(1):1–6. DOI: 10.12816/0010682
Dolashki A, Dolashka P, Stenzl A, et al. Antitumour activity of Helix hemocyanin against bladder carcinoma permanent cell lines. Biotechnology and Biotechnological Equipment. 2019;33(1):20–32. DOI: 10.1080/13102818.2018.1507755
Rethna Priya E, Ravichandran S. Anti cancer compounds of calappa calappa L. (1758). International Journal of Zoological Research. 2015;11(3):107–111. DOI: 10.3923/ijzr.2015.107.111.
The benefits of eating fish. Environmental Forum. 2007;24(5):7–8. Available:https://seafood.edf.org/benefits-eating-fish Accessed: September 2021.
Lauritano C, Martínez KA, Battaglia P, et al. First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species. Scientific Reports. 2020;10(1):1–8. DOI: 10.1038/s41598-020-61515-z
Kanthimathi P, Joslin P. Antimicrobial, Anticancer Properties from Various Tissues Extracts of Puffer Fish Arothron Stellatus from Thoothukudi Coast. International Research Journal of Engineering Technology. 2021;8(3): 3001–3008.
Gupta P, Serajuddin M. Fish Lipid against Prostate Cancer (PC-3) through Apoptosis and Cell Cycle Arrest. Nutrition and Cancer. 2020;73(2):300–306. DOI: 10.1080/01635581.2020.1743872
Lugo JM, Tafalla C, Oliva A, et al. Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans. Fish and Shellfish Immunology. 2019;86:559–570. DOI: 10.1016/j.fsi.2018.11.056
Halim NRA, Azlan A, Yusof HM, Sarbon NM. Antioxidant and anticancer activities of enzymatic eel (monopterus sp) protein hydrolysate as influenced by different molecular weight. Biocatalysis and Agricultural Biotechnology. 2018;16:10–16. DOI: 10.1016/j.bcab.2018.06.006
Som RSC, Pillai P, Lekshmi S, Radhakrishnan CK. Anticancer effect of polyunsaturated fatty acid extracts from sardine fishes on human cancer cell lines. Indian Journal of Geo-Marine Sciences. 2017;46(2):290–294. DOI: 10.21276/ijpbs.2016.6.4.10
Balasubramanian S, Revathi A, Gunasekaran G. Studies on anticancer, haemolytic activity and chemical composition of crude epidermal mucus of fish Mugil cephalus. Ijfas. 2016;4(5):438–443.
eNews: Fish and Your Cancer Risk: 4 Things You Need to Know; 2015. Available:https://www.aicr.org/news/fish-and-cancer-risk-4-things-you-need-to-know/ Accessed: October 2021.
Song J, Su H, Wang B et al. Fish Consumption and Lung Cancer Risk: Systematic Review and Meta-Analysis. Nutrition and Cancer. 2014;66(4):539–549. DOI: 10.1080/01635581.2014.894102
Nurdiani R. Anti-Carcinogenic Peptides Derived From Fish By-Products. Victoria University; 2017.
Guo CH, Hsia S, Chung CH, et al. Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice. Mar Drugs; 2021. DOI: 10.3390/md19040193
Amin ARMR, Kucuk O, Khuri FR, Shin DM. Perspectives for cancer prevention with natural compounds. Journal of clinical oncology: Official Journal of the American Society of Clinical Oncology 2009;27(16):2712– 25. DOI: 10.1200/JCO.2008.20.6235
Calcabrini C, Catanzaro E, Bishayee A, et al. Marine Sponge Natural Products with Anticancer Potential: An Updated Review. Marine Drugs. 2017;15(10):310. Doi: 10.3390/md15100310
Lai P, Roy J. Antimicrobial and Chemopreventive Properties of Herbs and Spices. Current Medicinal Chemistry. 2004;11(11):1451–1460. DOI: 10.2174/0929867043365107
Klausmeyer P, Chmurny GN, Mccloud TG, et al. A Novel Antimicrobial Indolizinium Alkaloid from Aniba panurensis. Journal of Natural Products. 2004;67(10):1732–1735.
El-Seedi HR, Sata N, Torssell KBG, Nishiyama S. New labdene diterpenes from Eupatorium glutinosum. Journal of Natural Products. 2002;65(5):728–729. DOI: 10.1021/np010595r
Faulkner DJ. Marine natural products. Natural Product Reports. 2001;18(1):1–49. DOI: 10.1039/b006897g
Ireland CM, Molinski TF, Roll DM, et al. Natural Product Peptides from Marine Organisms. In: Bioorganic Mar. Chem. 1989;l1–46.
Saadaoui I, Rasheed R, Abdulrahman N, et al. Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential. Marine Drugs. 2020;18(4):197. DOI: 10.3390/md18040197
Correia-da-Silva M, Sousa EE, Pinto MMM, Kijjoa A. Anticancer and cancer preventive compounds from edible marine organisms. Seminars in Cancer Biology. 2017;46(5):55–64. DOI: 10.1016/j.semcancer.2017.03.011
Chakraborty C, Hsu C-H, Wen Z-H, Lin C-S. Anticancer Drugs Discovery and Development from Marine Organisms. Current Topics in Medicinal Chemistry. 2009;9(16):1536–1545. DOI: 10.2174/156802609789909803.
Yang P, Cartwright C, Ding J, et al. Anticancer Activity of Fish Oils against Human Lung Cancer Is Associated with Changes in Formation of PGE2 and PGE3 and Alteration of Akt Phosphorylation. Mol Carcinog. 2014;53(7):566–577. DOI: 10.1016/j.physbeh.2017.03.040
Carballeira NM. New advances in fatty acids as antimalarial, antimycobacterial and antifungal agents. Progress in Lipid Research. 2008; 47(1):50–61. DOI: 10.1016/j.plipres.2007.10.002
Malaker A, Adil S, Ahmad I, et al. Therapeutic potency of anticancer peptides. Journal of Engineering And Applied Sciences. 2013;2 (3):82–94.
Newman DJ, Cragg GM. Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development. Marine Drugs. 2014 ;12(1):255–278. DOI: 10.3390/md12010255
Newman DJ, Cragg GM. Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010. Journal of Natural Products. 2012;75(3):311–335. DOI: 10.1021/np200906s
Nobili S, Lippi D, Witort E, et al. Natural compounds for cancer treatment and prevention. Pharmacological Research. 2009;59 (6):365–378. DOI: 10.1016/j.phrs.2009.01.017
Aquatic Organisms: Microorganisms. Available:http://www.ramp-alberta.org/river/ecology/life/microorganisms.aspx Accessed: September 2021.
Suja M, Vasuki S, Sajitha N. Anticancer Activity of Compounds Isolated From Marine Endophytic Fungus Aspergillus Terreus. World Journal of Pharmacy and Pharmaceutical Sciences. 2014;3(6):661– 672.
Dhaneesha M, Sajeevan TP. Anticancer Activity of Sponge Associated Actinomycetes Streptomyces sp. MCCB267 On Lung Cancer Cell Line. Proceedings of 28th Kerala Science Congress. 2016;1628–39.
Pham HT, Nguyen NP, Phi TQ, et al. The Antibacterial and Anticancer Activity of Marine Actinomycete Strain HP411 Isolated in the Northern Coast of Vietnam. World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering. 2014;8(12):780–784.
Wijaya AP, Bondar KG, Frederick EH, et al. Identification of marine bacteria HPP.4A and HPP.T13 and its anticancer activity against P388 murine leukaemia cell. IOP Conference Series: Earth and Environmental Science. 2020;584 (1):0–6. DOI: 10.1088/1755-1315/584/1/012005
Weisse T. Functional diversity of aquatic ciliates. European Journal of Protistology. 2017;61:331–358. DOI: 10.1016/j.ejop.2017.04.001
Calow J, Behrens AJ, Mader S, et al. Antibody production using a ciliate generates unusual antibody glycoforms displaying enhanced cell-killing activity. mAbs. 2016;8(8):1498–1511. DOI: 10.1080/19420862.2016.1228504
Carpi S, Polini B, Poli G, et al. Anticancer activity of euplotin C, isolated from the marine ciliate euplotes crassus, against human melanoma cells. Mar Drugs; 2018. DOI: 10.3390/md16050166
Beneficial Aquatic Plants. Available:https://www.aquaticbiologists.com/beneficial-plants/ Accessed: September 2021.
Aquatic Organisms: Plants - Regional Aquatics Monitoring Program (RAMP). http://www.ramp-alberta.org/river/ecology/life/plants.aspx Accessed: September 2021.
Freshwater algae: Native plants; 2017. Available:https://www.doc.govt.nz/nature/native-plants/freshwater-algae/ Accessed: September 2021.
Awati SS, Singh SK, Wadkar KA. In vitro Antioxidant potential and Anticancer activity of Ceratophyllum demersum Linn. extracts on HT-29 human colon cancer cell line. Research Journal of Pharmacy and Technology. 2021;14 (1):28–36. DOI: 10.5958/0974-360X.2021.00006.8
Lenora LM, Senthil Kumar J, Murugesan S, Senthilkumar N. Anticancer Activity of Water Hyacinth [ Eichhornia Crassipes (Mart) Solms] on Human Cervical Cancer Cell Line. Octa Journal of Environmental Research. 2015; 3(4):327–331.
Saeed AM, Abotaleb SI, Alam NG, et al. In vitro assessment of antimicrobial, antioxidant and anticancer activities of some marine macroalgae. Egyptian Journal of Botany. 2020;60(1):81–96. DOI: 10.21608/ejbo.2019.11363.1303
Hemasudha T., Thiruchelvi R, Balashanmugam P. Antioxidant, antibacterial, and anticancer activity from marine red algae gracilaria edulis. Asian Journal of Pharmaceutical and Clinical Research. 2019;12(2):276–279. DOI: 10.22159/ajpcr.2019.v12i2.29883
Miranda-Delgado A, Montoya MJ, Paz-Araos M, et al. Antioxidant and anti-cancer activities of brown and red seaweed extracts from chilean coasts. Latin American Journal of Aquatic Research. 2018;46(2):301–313. DOI: 10.3856/vol46-issue2-fulltext-6
Lezcano V, Fernández C, Parodi ER, Morelli S. Antitumor and antioxidant activity of the freshwater macroalga Cladophora surera. Journal of Applied Phycology. 2018;30(5): 2913–2921. DOI: 10.1007/s10811-018-1422-5
Marudhupandi T, Ajith Kumar TT, Lakshmanasenthil S, et al. In vitro anticancer activity of fucoidan from Turbinaria conoides against A549 cell lines. International Journal of Biological Macromolecules. 2015;72:919–23. DOI: 10.1016/j.ijbiomac.2014.10.005
Aquatic Organisms: Invertebrates - Regional Aquatics Monitoring Program (RAMP). Available:http://www.ramp-alberta.org/river/ecology/life/invertebrates.aspx Accessed: September 2021.
Ciftci HI, Can M, Ellakwa DE, et al. Anticancer activity of Turkish marine extracts: A purple sponge extract induces apoptosis with multitarget kinase inhibition activity. Investigational New Drugs. 2020;38(5):1326–1333. DOI: 10.1007/s10637-020-00911-8
Eltamany E, Eltahawy N, Ibrahim A, et al. Anticancer Activities of Some Organisms from Red Sea, Egypt. Catrina: The International Journal of Environmental Sciences. 2014;9(1):1–6. DOI: 10.12816/0010682
Dolashki A, Dolashka P, Stenzl A, et al. Antitumour activity of Helix hemocyanin against bladder carcinoma permanent cell lines. Biotechnology and Biotechnological Equipment. 2019;33(1):20–32. DOI: 10.1080/13102818.2018.1507755
Rethna Priya E, Ravichandran S. Anti cancer compounds of calappa calappa L. (1758). International Journal of Zoological Research. 2015;11(3):107–111. DOI: 10.3923/ijzr.2015.107.111.
The benefits of eating fish. Environmental Forum. 2007;24(5):7–8. Available:https://seafood.edf.org/benefits-eating-fish Accessed: September 2021.
Lauritano C, Martínez KA, Battaglia P, et al. First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species. Scientific Reports. 2020;10(1):1–8. DOI: 10.1038/s41598-020-61515-z
Kanthimathi P, Joslin P. Antimicrobial, Anticancer Properties from Various Tissues Extracts of Puffer Fish Arothron Stellatus from Thoothukudi Coast. International Research Journal of Engineering Technology. 2021;8(3): 3001–3008.
Gupta P, Serajuddin M. Fish Lipid against Prostate Cancer (PC-3) through Apoptosis and Cell Cycle Arrest. Nutrition and Cancer. 2020;73(2):300–306. DOI: 10.1080/01635581.2020.1743872
Lugo JM, Tafalla C, Oliva A, et al. Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans. Fish and Shellfish Immunology. 2019;86:559–570. DOI: 10.1016/j.fsi.2018.11.056
Halim NRA, Azlan A, Yusof HM, Sarbon NM. Antioxidant and anticancer activities of enzymatic eel (monopterus sp) protein hydrolysate as influenced by different molecular weight. Biocatalysis and Agricultural Biotechnology. 2018;16:10–16. DOI: 10.1016/j.bcab.2018.06.006
Som RSC, Pillai P, Lekshmi S, Radhakrishnan CK. Anticancer effect of polyunsaturated fatty acid extracts from sardine fishes on human cancer cell lines. Indian Journal of Geo-Marine Sciences. 2017;46(2):290–294. DOI: 10.21276/ijpbs.2016.6.4.10
Balasubramanian S, Revathi A, Gunasekaran G. Studies on anticancer, haemolytic activity and chemical composition of crude epidermal mucus of fish Mugil cephalus. Ijfas. 2016;4(5):438–443.
eNews: Fish and Your Cancer Risk: 4 Things You Need to Know; 2015. Available:https://www.aicr.org/news/fish-and-cancer-risk-4-things-you-need-to-know/ Accessed: October 2021.
Song J, Su H, Wang B et al. Fish Consumption and Lung Cancer Risk: Systematic Review and Meta-Analysis. Nutrition and Cancer. 2014;66(4):539–549. DOI: 10.1080/01635581.2014.894102
Nurdiani R. Anti-Carcinogenic Peptides Derived From Fish By-Products. Victoria University; 2017.
Guo CH, Hsia S, Chung CH, et al. Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice. Mar Drugs; 2021. DOI: 10.3390/md19040193
-
Abstract View: 676 times
PDF Download: 19 times