PHARMACOVIGILANCE OF FIXED DOSAGE FOR COMBINATION DRUGS
N. S. MUTHIAH
Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry 605502 Affiliated to Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
APARNA RAVI
Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry 605502 Affiliated to Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
JAYALAKSHMI G. *
Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry 605502 Affiliated to Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
Pharmacovigilance refers to research and practices relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related concern. A key concern with the sale of prohibited pharmaceuticals over the counter in India is that there aren't enough adverse drug response (ADR) statistics on these drugs. The gastrointestinal system was the site of the majority of suspected ADRs, with patients reporting epigastric pain, nausea, and loose stools, followed by dermatological symptoms such as rashes, pruritus, and so on. The respiratory, auditory, immune, and central nervous systems were also implicated. Every drug reaction was double-checked with the treating physician and the literature. Antibiotic fixed dose combinations and non- steroidal anti-inflammatory drug fixed dose combinations produced the most ADRs, followed by analgesics and antipyretics fixed dose combinations, fluoroquinolones, and antihypertensive fixed dose combinations.
Keywords: Pharmacovigilance, combination drugs, antihypertensives, adverse drug reaction