Published: 2021-12-28

Page: 1010-1014


Department of Medicine, Krishna Institute of Medical Sciences Deemed to be University, Karad, Satara, Maharashtra, India.


Department of Medicine, Krishna Institute of Medical Sciences Deemed to be University, Karad, Satara, Maharashtra, India.


Department of Medicine, Krishna Institute of Medical Sciences Deemed to be University, Karad, Satara, Maharashtra, India.

*Author to whom correspondence should be addressed.


Introduction:  Acute coronary syndrome (ACS) is a common emergency faced by physician during career. ACS is leading cause of mortality and morbidity in all over the world. Hence there is growing interest across the globe to find out various factors which could predict the prognosis of patient suffering from ACS. Objective: To study possible association between hemoglobin A1c(HbA1c) and admission glucose level identified during initial hospitalization in patients with acute coronary syndromes. Method: This hospital based prospective observational study was carried out for the period of 15 months from January 2017 to March 2018. A total of 100 patients who presented with ACS to the Emergency medicine Department under the Department of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Sangli, Maharashtra were studied. The Results: Most of the patients were males (54%) and male to female ratio was 1.17:1. Most of the patients were (37%) aged between 61 to 70 years and 32% of the patients were aged between 51 to 60 years. The mean age was 62.36±9.89 years. Conclusion: Based on the above results it may be concluded that, admission glycated haemoglobin levels are associated with in hospital adverse events as well as outcome while outcome and adverse events were independent of blood sugar levels that is, random, fasting and post prandial blood sugar levels hence, blood sugar levels have limited prognostic value in patient with Acute coronary syndrome (ACS).

Keywords: Acute coronary syndrome (ACS), HbA1c, admission glucose level, haemoglobin, prandial blood sugar levels

How to Cite

KASIREDDY, S. R., PATIL, V. C., & DAMLE, A. J. (2021). A STUDY OF GLYCOSYLATED HEMOGLOBIN (HBA1C) IN ACUTE CORONARY SYNDROME. UTTAR PRADESH JOURNAL OF ZOOLOGY, 42(24), 1010–1014. Retrieved from https://mbimph.com/index.php/UPJOZ/article/view/2836


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Hauffman MD. Coronary heart disease in India. Centre for Chronic Disease Control. Available : sancd.org/uploads/pdf/factsheet _CHD.pdf Access Date: 18.09.2018

Storrow AB, Gibler WB. Chest pain centers: diagnosis of acute coronary syndromes. Ann Emerg Med. 2000;35:449-61.

Narayana RH, Kallige NC, Prabhu MV, Chowta MN, Unnikrishnan B. Association between glycosylated hemoglobin and acute coronary syndrome in type 2 diabetes mellitus. Arch Med Health Sci. 2015;3:29-33.

Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: A systematic overview. Lancet. 2000;355:773-8.

Haffner SM, Stern MP, Hazuda HP etal. Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart diseases start ticking before the onset of clinical diabetes. JAMA. 1990;263;2893-8.

Selvin E, Steffes MW, Zhu H, Matsushita K, Wagenknecht L, Pankow J, et al. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med. 2010;362:800-11.

Lippi G, Sanchis-Gomar F, Cervellin G. Chest pain, dyspnea and other symptoms in patients with type 1 and 2 myocardial infarction. A literature review. Int J Cardiol. 2016;215: 20-2.

Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 2016;4(13):256.

Hamm CW, Heeschen C, Falk E, Fox KAA. Acute Coronary Syndromes: Pathophysiology, Diagnosis and Risk Stratification.

Overhaugh KJ. Acute coronary syndrome. Am J Nurs. 2009;109(5):42-52.

Mansoor AH, Kaul U. Pre-hospital thrombolysis. Indian Heart J. 2009; 61:433-6.

Singh S, Bansal M, Rani K, Gupta V. Prognostic significance of glycosylated hemoglobin in nondiabetic patients in acute coronary syndrome. Heart India. 2016;4:17-22.

Selvin E, Marinopoulos S, Berkenblit G, Rami T, Brancati FL, Powe NR, et al. Meta‑analysis: Glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med. 2004;141:421‑31.

Khaw KT, Wareham N, Bingham S, Luben R, Welch A, Day N. Association of hemoglobin A1c with cardiovascular disease and mortality in adults: The European prospective investigation into cancer in Norfolk. Ann Intern Med. 2004;141:413‑20.

Sato KK, Hayashi T, Harita N, Yoneda T, Nakamura Y, Endo G, et al. Combined measurement of fasting plasma glucose and A1C is effective for the prediction of type 2 diabetes: The Kansai Healthcare Study. Diabetes Care. 2009;32:644‑6.

Jorik Rudolf Timmer, Clinical implications of glycometabolic disturbances in acute coronary syndromes / Jorik Rudolf Timmer.[S.l.:s.n.], ([Ensch ede]:Febodruk).2005;203: ill.; 24 cm.

Zaghla HE, Elbadry MA, Ashour AM, Abdelfatah MM. Influence of admission blood glucose and hemoglobin A1c on outcome of acute myocardial infarction. Egypt J Intern Med. 2014;26:21-6.

The NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283– 1297.

Kosiborod M, McGuire DK. Glycated hemoglobin as a prognostic risk marker in nondiabetic patients after acute myocardial infarction. Circulation. 2011;124:666–668.