MARKET ASPECTS, THERAPEUTIC ADVANCEMENTS AND SYNERGISTIC POTENTIAL OF BLACK PEPPER

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Published: 2021-12-31

DOI: 10.56557/upjoz/2021/v42i243316

Page: 1519-1531


JINDAL HEENA *

School of Pharmaceutical Sciences, Apeejay Stya University, Sohna, Gurugram, Haryana-122103, India.

PATEL SHITAL

School of Pharmaceutical Sciences, Apeejay Stya University, Sohna, Gurugram, Haryana-122103, India.

RANA SHIVANI

School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences and Technology, Baddi, Solan, H.P.-173205, India.

ROY LOPAMUDRA

School of Pharmaceutical Sciences, Apeejay Stya University, Sohna, Gurugram, Haryana-122103, India.

*Author to whom correspondence should be addressed.


Abstract

Black pepper (Piper nigrum L.) is widely regarded as the "king of spices" due to its enormous trading share in the world market. This worldwide trade is not only attributed to its pungency properties, but widely due to its great health benefits and richness in the bioactive components. From the ancient times to the modern science, the black pepper has evolved as a one of the important medicinal agents which is not only used in the kitchen for its nutritional and heath properties, but widely employed in the pharmaceutical sciences for its scientifically proven pharmacological actions and therapeutic role. These actions are mainly due to the presence of the alkaloids, flavonoids, steroids, phenols, amides, lignans, essential oil etc. Piperine, a piperidine alkaloid and its derivatives are widely employed as a bioavailability enhancer and produces synergistic effects with many other phytoconstituents or medicinal drugs and contribute to improve the bioactivity, dose reduction, and even lessen the side effects of many pharmaceutical drugs. Black pepper is widely employed to increase appetite, treats the hypertension, cough, sinusitis, vomiting, epilepsy, gastric problems, dyspnea, worm infections, and skin diseases. It also found to possess several important pharmacological properties such as antimicrobial, analgesic, anti-inflammatory, antioxidant, anticonvulsant, hypolipidemic, hypoglycemic, hepatoprotective, neuroprotective, and anticancer activities. Due to these wide applications, the trade of black pepper is increasing day-by-day all the world. The black pepper is mainly produced throughout the world especially in Vietnam, India, Indonesia, Brazil, Malaysia, China, and Sri Lanka. In India, Karnataka, and Kerala account for almost 55 % and 34 % of the total production respectively. The present review outlined the recent advancements in therapeutic potential of black pepper (Piper nigrum L.) along with its synergism and analysed the trade performance in terms of area, production, import and export of black pepper in the world focusing on India.

Keywords: Black pepper, bioavailability, phytochemistry, pharmacology, synergism, trade


How to Cite

HEENA, J., SHITAL, P., SHIVANI, R., & LOPAMUDRA, R. (2021). MARKET ASPECTS, THERAPEUTIC ADVANCEMENTS AND SYNERGISTIC POTENTIAL OF BLACK PEPPER. UTTAR PRADESH JOURNAL OF ZOOLOGY, 42(24), 1519–1531. https://doi.org/10.56557/upjoz/2021/v42i243316

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References

Reading Manual for Black Pepper processing under PMFME Scheme.

Available:http://www.niftem.ac.in/site/pmfme/lmnew/blackpepperwriteup.pdf.

Yogesh MS, Mokshapathy S. Production and export performance of black pepper. Int. J Humanit Soc. Sci. Invent. 2013;2:36-44.

CATR-centre for advance trade research, (TPCI). Product profile: spices; 2019.

Available:https://www.tpci.in/indiabusinesstrade/blogs/product-profile-spices/.

Sabu SS, Kuruvila A. Price instability in black pepper: A comparative analysis of preliberalisation and post-liberalisation periods. Trop Agric. 2016;54:41.

The ayurvedic pharmacopoeia of India. Part Volume; III (Ministry of Health and Family Welfare, Department of ISM, H, Govt. of India; 2001.

ICMR. Reviews on Indian medicinal plants volume −20 (Pho-Pip). Medicinal Plants Division, Indian Council of Medical Research; 2019.

Srinivasan K. Black pepper (Piper nigrum) and its bioactive compound, piperine. Molecular targets and therapeutic uses of spices: Modern uses for ancient medicine 25-64. World Scientific, 2009.

Hammouti B et al. Black Pepper, the “King of Spices”: chemical composition to applications. Arab J Chem Environ Res. 2019;6:12-56.

Damanhouri ZA, Ahmad A. A review on therapeutic potential of Piper nigrum L. (Black Pepper): the King of Spices. Med Aromat Plants. 2014;3:161.

De Waard PWF, Zeven AC. Piper nigrum L. Outlines Perennial Crop Breed Tropics. 1999;409.

Zhu F, Mojel R, Li G. Structure of black pepper (Piper nigrum) starch. Food Hydrocoll. 2017;71:102-7.

Tainter DR, Grenis AT. Spices and seasonings: a food technology handbook. John Wiley & Sons; 2001.

Nwofia GE, Kelechukwu C, Nwofia BK. Nutritional composition of some Piper nigrum (L.) accessions from Nigeria. Int J Med Aromat Plants 3. 2013;4340:2249.

Shityakov S, Bigdelian E, Hussein AA, Hussain MB, Tripathi YC, Khan MU et al. Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper. Eur J Med Chem. 2019;176:149-61.

Orav A, Stulova I, Kailas T, Müürisepp M. Effect of storage on the essential oil composition of Piper nigrum L. fruits of different ripening states. J Agric Food Chem. 2004;52(9):2582-6.

Ashokkumar K, Murugan M, Dhanya MK, Pandian A, Warkentin TD. Phytochemistry and therapeutic potential of black pepper [Piper nigrum (L.)] essential oil and piperine: a review. Clin Phytosci. 2021;7:1-11.

Milenković AN, Stanojević LP. Black pepper: chemical composition and biological activities. Adv Techol. 2021;10(2):40-50.

DOI: 10.5937/savteh2102040M.

Oersted Bdas P. ein neues Pflanzenalkaloid"[On piperine, a new plant alkaloid], (Schweigger’s). J Chem Phys. 1820;29:80-2.

Narayanan CS. Chemistry of black pepper. In: Black pepper. CRC Press. 2000;165-84.

Traxler JT. Piperanine, a pungent component of black pepper. J Agric Food Chem. 1971;19(6):1135-8.

Gorgani L, Mohammadi M, Najafpour GD, Nikzad M. Piperine—the bioactive compound of black pepper: from isolation to medicinal formulations. Compr Rev Food Sci Food Saf. 2017;16(1):124-40.

Ali A, Wu H, Ponnampalam EN, Cottrell JJ, Dunshea FR, Suleria HAR. Comprehensive profiling of most widely used spices for their phenolic compounds through lc-esi-qtof-ms2 and their antioxidant potential. Antioxidants (Basel). 2021;10(5):721.

Ashokkumar K, Pandian A, Murugan M, Dhanya MK, Sathyan T, Sivakumar P et al. Profiling bioactive flavonoids and carotenoids in select south Indian spices and nuts. Nat Prod Res. 2020;34(9):1306-10.

Takooree H, Aumeeruddy MZ, Rengasamy KRR, Venugopala KN, Jeewon R, Zengin G et al. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications. Crit Rev Food Sci Nutr. 2019;59(sup1):S210-43.

Bhuyan B, Baishya K. Ethno medicinal value of various plants used in the preparation of traditional rice beer by different tribes of Assam, India. Drug Invent Today. 2013;5(4):335-41.

Upadhyay B, Parveen, Dhaker AK, Kumar A. Ethnomedicinal and ethnopharmaco-statistical studies of Eastern Rajasthan, India. J Ethnopharmacol. 2010;129(1):64-86.

Policepatel SS, Manikrao VG. Ethnomedicinal plants used in the treatment of skin diseases in Hyderabad Karnataka region, Karnataka, India. Asian Pac J Trop Biomed. 2013;3(11):882-6.

Dey A, Gorai P, Mukherjee A, Dhan R, Modak BK. Ethnobiological treatments of neurological conditions in the Chota Nagpur Plateau, India. J Ethnopharmacol. 2017;198:33-44.

Mallik BK, Panda T, Padhy RN. Traditional herbal practices by the ethnic people of Kalahandi district of Odisha, India. Asian Pac J Trop Biomed. 2012;2(2):S988-94.

Bhatia H, Pal Sharma YP, Manhas RK, Kumar K. Traditional phytoremedies for the treatment of menstrual disorders in district Udhampur, J&K, India. J Ethnopharmacol. 2015;160:202-10.

Patel JJ, Acharya SR, Acharya NS. Clerodendrum serratum (L.) moon. – a review on traditional uses, phytochemistry and pharmacological activities. J Ethnopharmacol. 2014;154(2):268-85.

Behera SK, Misra MK. Indigenous phytotherapy for genito-urinary diseases used by the Kandha tribe of Orissa, India. J Ethnopharmacol. 2005;102(3):319-25.

Upasani SV, et al. Ethnomedicinal plants used for snakebite in India: a brief overview. Integr Med Res. 2017;6:114–130.

Sethiya NK, Ahmed NM, Shekh RM, Kumar V, Kumar Singh P, Kumar V. Ethnomedicinal, phytochemical and pharmacological updates on Hygrophila auriculata (Schum.) Hiene: an overview. J Integr Med. 2018;16(5):299-311.

Ayyanar M, Ignacimuthu S. Traditional knowledge of kani tribals in Kouthalai of Tirunelveli hills, Tamil Nadu, India. J Ethnopharmacol. 2005;102(2):246-55.

Chander MP, Kartick C, Vijayachari P. Ethnomedicinal knowledge among Karens of Andaman & Nicobar Islands, India. J Ethnopharmacol. 2015;162:127-33.

Vijayakumar S, Morvin Yabesh JEM, Prabhu S, Manikandan R, Muralidharan B. Quantitative ethnomedicinal study of plants used in the Nelliyampathy hills of Kerala, India. J Ethnopharmacol. 2015;161:238-54.

Bhat P, Hegde G, Hegde GR. Ethnomedicinal practices in different communities of Uttara Kannada district of Karnataka for treatment of wounds. J Ethnopharmacol. 2012;143(2):501-14.

Sharma J, Gairola S, Gaur RD, Painuli RM, Siddiqi TO. Ethnomedicinal plants used for treating epilepsy by indigenous communities of sub-Himalayan region of Uttarakhand, India. J Ethnopharmacol. 2013;150(1):353-70.

Bhat P, Hegde GR, Hegde G, Mulgund GS. Ethnomedicinal plants to cure skin diseases—an account of the traditional knowledge in the coastal parts of Central Western Ghats, Karnataka, India. J Ethnopharmacol. 2014;151(1):493-502.

Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK. Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review. J Ethnopharmacol. 2011;138(2):286-313.

Sharma J, Gairola S, Gaur RD, Painuli RM. The treatment of jaundice with medicinal plants in indigenous communities of the Sub-Himalayan region of Uttarakhand, India. J Ethnopharmacol. 2012;143(1):262-91.

Sureshkumar J, Silambarasan R, Ayyanar M. An ethnopharmacological analysis of medicinal plants used by the Adiyan community in Wayanad district of Kerala, India. Eur J Integr Med. 2017;12:60-73.

Pei H, Xue L, Tang M, Tang H, Kuang S, Wang L et al. Alkaloids from black pepper (Piper nigrum L.) exhibit anti-inflammatory activity in murine macrophages by inhibiting activation of NF-κB pathway. J Agric Food Chem. 2020;68(8):2406-17.

Singh R, Singh N, Saini BS, Rao HS. In vitro antioxidant activity of pet ether extract of black pepper. Indian J Pharmacol. 2008;40(4):147-51.

Liu Y, Yadev VR, Aggarwal BB, Nair MG. Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B. Nat Prod Commun. 2010;5(8):1253-7.

El Hamss R, Idaomar M, Alonso-Moraga A, Muñoz Serrano AM. Antimutagenic properties of bell and black peppers. Food Chem Toxicol. 2003;41(1):41-7.

Mao QQ, Huang Z, Zhong XM, Xian YF, Ip SP. Piperine reverses the effects of corticosterone on behavior and hippocampal BDNF expression in mice. Neurochem Int. 2014;74:36-41.

Li S, Wang C, Wang M, Li W, Matsumoto K, Tang Y. Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sci. 2007;80(15):1373-81.

Khan M, Siddiqui M. Antimicrobial activity of Piper fruits; 2007.

Kaho ZM, Kadum AR, Hadi AA. Evaluation of antibacterial activity of Piper nigrum extract against Streptococcus mutans and Escherichia coli. J Pharm Sci. Res. 2019;11:367-70.

Shamkuwar PB, Shahi SR, Jadhav ST. Evaluation of antidiarrhoeal effect of black pepper (Piper nigrum L.). Asian J Plant Sci. Res. 2012;2:48-53.

Mair CE et al. Antiviral and anti-proliferative in vitro activities of piperamides from black pepper. Planta Med. 2016;82:807.

Bukhari IA, Pivac N, Alhumayyd MS, Mahesar AL, Gilani AH. The analgesic and anticonvulsant effects of piperine in mice. J Physiol Pharmacol. 2013;64(6):789-94.

Chen CY, Li W, Qu KP, Chen CR. Piperine exerts anti-seizure effects via the TRPV1 receptor in mice. Eur. J Pharmacol. 2013;714(1-3):288-94.

Kanedi M. The effect of fruit extracts of black pepper on the fertility potential of male albino rats. Am J Med Biol Res. 2016;3:1-4.

Ramanaiah I, Sudeep HV, Shyamprasad K. ViphyllinTM, a standardized black pepper extract exerts antihyperglycemic effect and improves sciatic nerve conduction in high fat diet/streptozotocin-induced diabetic model rats. Diabetes Metab Syndr Obes. 2022;15:1819-29.

Atal CK, Zutshi U, Rao PG. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. J Ethnopharmacol. 1981;4(2):229-32.

Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353-6.

Hiwale AR, Dhuley JN, Naik SR. Effect of co-administration of piperine on pharmacokinetics of β-lactam antibiotics in rats. Indian J Exp Biol. 2002;40(3):277-81.

Lambert JD, Hong J, Kim DH, Mishin VM, Yang CS. Piperine enhances the bioavailability of the tea polyphenol (−)-epigallocatechin-3-gallate in mice. J Nutr. 2004;134(8):1948-52.

Makhov P, Golovine K, Canter D, Kutikov A, Simhan J, Corlew MM et al. Co‐administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity. Prostate. 2012;72(6):661-7.

Bano G, Raina RK, Zutshi U, Bedi KL, Johri RK, Sharma SC. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol. 1991;41(6):615-7.

Velpandian T, Jasuja R, Bhardwaj RK, Jaiswal J, Gupta SK. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet. 2001;26(4):241-7.

Badmaev V, Majeed M, Prakash L. Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. J Nutr Biochem. 2000;11(2):109-13.

Badmaev V, Majeed M, Norkus EP. Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation. Nutr Res. 1999;19(3):381-8.

Allameh A, Saxena M, Biswas G, Raj HG, Singh J, Srivastava N. Piperine, a plant alkaloid of the piper species, enhances the bioavailability of aflatoxin b1 in rat tissues. Cancer Lett. 1992;61(3):195-9.

Chawla PC. Resorine A novel CSIR drug curtails TB treatment. CSIR News. 2010;60:52-4.

Endah E, Wulandari F, Putri Y, Jenie RI, Meiyanto E. Piperine increases Pentagamavunon-1 anti-cancer activity on 4T1 breast cancer through mitotic catastrophe mechanism and senescence with sharing targeting on mitotic regulatory proteins. Iran J Pharm Res. 2022;21(1):e123820.

Priya A, Pandian SK. Biofilm and hyphal inhibitory synergistic effects of phytoactives piperine and cinnamaldehyde against Candida albicans. Med Mycol. 2022;60(8).

Fattah A, Morovati A, Niknam Z, Mashouri L, Asadi A, Rizi ST et al. The synergistic combination of cisplatin and piperine induces apoptosis in MCF-7 cell line. Iran J Public Health. 2021;50(5):1037-47.

Bisso Ndezo B, Tokam Kuaté CR, Dzoyem JP. Synergistic antibiofilm efficacy of thymol and piperine in combination with three aminoglycoside antibiotics against Klebsiella pneumoniae biofilms. Can J Infect Dis Med Microbiol. 2021;2021:7029944.

Srivastava S, Dewangan J, Mishra S, Divakar A, Chaturvedi S, Wahajuddin M et al. Piperine and celecoxib synergistically inhibit colon cancer cell proliferation via modulating Wnt/β-catenin signaling pathway. Phytomedicine. 2021;84:153484.

Esposito T, Lucariello A, Hay E, Contieri M, Tammaro P, Varriale B et al. Effects of curcumin and its adjuvant on TPC1 thyroid cell line. Chem Biol Interact. 2019;305: 112-8.

Ghelishli N, Ghasemi A, Hosseinimehr SJ. The influence of piperine on the radioprotective effect of curcumin in irradiated human lymphocytes. Turk J Pharm Sci. 2019;16(3):366-70.

Shin J, Lee YM, Oh J, Jung S, Oh JW. Effects of gamma-aminobutyric acid and piperine on gene regulation in pig kidney epithelial cell lines. Asian-Australas J Anim Sci. 2020;33(9):1497-506.

Biswas S, Kar A, Sharma N, Haldar PK, Mukherjee PK. Synergistic effect of ursolic acid and piperine in CCl4 induced hepatotoxicity. Ann Med. 2021;53(1):2009-17.

Safdari F, Gholipour MD, Ghadami A, Saeed M, Zandi M. Multi-antibacterial agent-based electrospun polycaprolactone for active wound dressing. Prog Biomater. 2022;11(1):27- 41.

Tokam Kuaté CR, Bisso Ndezo B, Dzoyem JP. Synergistic antibiofilm Effect of thymol and piperine in Combination with Aminoglycosides antibiotics against four Salmonella enterica serovars. Evid Based Complement Alternat Med. 2021;2021:1567017.

Abolhassani H, Safavi MS, Handali S, Nosrati M, Shojaosadati SA. Synergistic effect of self-assembled curcumin and piperine co-loaded human serum albumin nanoparticles on suppressing cancer cells. Drug Dev Ind Pharm. 2020;46(10):1647-55.

CBI, Ministry of Foreign Affairs. Netherlands (Europe).

Available: https://www.cbi.eu/market-information/spices-herbs/pepper/market-potential.

Trade Statistics for International Business Development. International Trade Centre (ITC).

Available: https://www.trademap.org.

International Pepper Community UNESCAP Intergovernmental Organization.

Available: htps://www.ipcnet.org.

Spices Board India. Ministry of Commerce and Industry: Government of India.

Available: http://www.indianspices.com/.

Product profile; 2021. APEDA (Agricultural and Processed Food Products Export Development Authority).

Available: https://agriexchange.apeda.gov.in.